In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility

Soto, Robert J.; Hall, Jori N.; Brown, Micah; Taylor, James B.; Schoenfisch, Mark H.

doi:10.1021/acs.analchem.6b04251

Cited by 68 publications

(60 citation statements)

References 268 publications

(741 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One strategy to inhibit the foreign body reaction is to release anti‐inflammatory drugs in the vicinity of a biosensor. Drug‐releasing polymer layers or microfluidic systems can be integrated into microfabricated probes (Figure ) and biosensors coated with a porous polymer membrane containing anti‐inflammatory pharmaceutical agents have been proposed . Nitric oxide (NO) is a molecule that blocks platelet aggregation and hemostasis, and it also displays anti‐inflammatory and pro‐angiogenic properties that make it a prime candidate for being incorporated into in vivo biosensors to improve biocompatibility .…”

Section: Biocompatibilitymentioning

confidence: 99%

“…Drug‐releasing polymer layers or microfluidic systems can be integrated into microfabricated probes (Figure ) and biosensors coated with a porous polymer membrane containing anti‐inflammatory pharmaceutical agents have been proposed . Nitric oxide (NO) is a molecule that blocks platelet aggregation and hemostasis, and it also displays anti‐inflammatory and pro‐angiogenic properties that make it a prime candidate for being incorporated into in vivo biosensors to improve biocompatibility . Dexamethasone has also been incorporated into hydrogel membranes by using microspheres or carbon nanotubes , and its slow release into the local microenvironment has been shown to block scar formation.…”

Section: Biocompatibilitymentioning

confidence: 99%

See 1 more Smart Citation

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

2018

View full text Add to dashboard Cite

Chemical analyses of brain interstitial fluid can reveal important information about local brain metabolism and neurochemistry, and can enhance our understanding of how neuronal networks respond to physiological or pathological stimuli. Among brain monitoring methods currently available, microelectrode biosensors provide real‐time analyses with high temporal resolution and minimal perturbation to living tissue by using oxidase enzymes for biological recognition. Two types of microelectrodes are used: cylindrically shaped wire electrodes provide the smallest implantable devices to date, and microfabricated multi‐electrode needles can monitor several molecules simultaneously. They have already contributed significantly to our understanding of brain energy metabolism with glucose and lactate detection, and to neurotransmitter systems with glutamate, D‐serine, acetylcholine, and purine detection. They have the potential to undergo further technological developments in future studies.

show abstract

Section: Biocompatibilitymentioning

confidence: 99%

Section: Biocompatibilitymentioning

confidence: 99%

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

2018

View full text Add to dashboard Cite

show abstract

“…[ 30,32 ] Owing to this short half‐life, the sphere of influence of NO is limited around its origin; using Fick's second law of diffusion, its diffusion distance at half‐life is 5–490 µm. [ 33 ] Due to this extremely short physiological half‐life in vivo and localized concentration, only techniques such as fluorescence imaging, [ 34 ] electron paramagnetic resonance (EPR) spectroscopy, [ 35 ] and electrochemical sensors [ 30,36 ] have been able to provide some answers. For example, EPR measurements in vivo on the brains of rabies‐infected rats have determined NO concentrations of 1 × 10 −6 m or less in healthy rats, which increased to ≈12 × 10 −6 m at day 5 postinfection (onset of the disease) and to ≈30 × 10 −6 m at day 7.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide to Fight Viral Infections

2021

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID‐19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) that has quickly and deeply affected the world, with over 60 million confirmed cases. There has been a great effort worldwide to contain the virus and to search for an effective treatment for patients who become critically ill with COVID‐19. A promising therapeutic compound currently undergoing clinical trials for COVID‐19 is nitric oxide (NO), which is a free radical that has been previously reported to inhibit the replication of several DNA and RNA viruses, including coronaviruses. Although NO has potent antiviral activity, it has a complex role in the immunological host responses to viral infections, i.e., it can be essential for pathogen control or detrimental for the host, depending on its concentration and the type of virus. In this Essay, the antiviral role of NO against SARS‐CoV, SARS‐CoV‐2, and other human viruses is highlighted, current development of NO‐based therapies used in the clinic is summarized, existing challenges are discussed and possible further developments of NO to fight viral infections are suggested.

show abstract

“…These challenges may partially or completely hinder the function of implanted sensors, including accuracy and service life. [ 313,314 ]…”

Section: Applications Of Anti‐fbr Materialsmentioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

View full text Add to dashboard Cite

Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

show abstract

In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility

Abstract: Graphical Abstract

Cited by 68 publications

References 268 publications

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

Nitric Oxide to Fight Viral Infections

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Contact Info

Product

Resources

About