In vivo CNS Activity of Methanolic Extract of Ficus racemosa Fruits in Experimental Animals

Munira, Mst. Shirajum; Islam, Shariful; Baharuddin, Baharuddin; Koly, Sabiha Ferdowsy

doi:10.3329/bpj.v21i2.37925

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The open-field test is a type of experimental test that is used in scientific research to measure the general levels of locomotion, anxiety, and readiness to explore in animals (often rats). A rise in locomotor activity is a sign of excitation, whereas a decline in locomotor activity is a sign of sedation [ 33 ]. In the event of a CNS depression, the number of squares traversed by each mouse at the regular interval time will be lower, while the number of squares will be higher in the case of a CNS stimulant [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

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Sonneratia caseolaris (L.) is a common mangrove plant which has significant medicinal value in traditional medicine. Ethanol extract from the fruits of S. caseolaris (SCE) was used in this project to explore its different pharmacological effects considering its traditional usage. In the castor oil-induced diarrheal method, SCE significantly lengthened the latency of the first defecation period up to 95.8 and 119.4 min as well as lowering stool count by 43.3% and 64.4% at the doses of 250 and 500 mg/kg, respectively. In evaluating the neuropharmacological effect using the open-field model, a significant central nervous system (CNS) depressant nature was observed after a reduction in the no. of squares crossed by mice at various time intervals. In evaluating the blood coagulation effect, SCE significantly reduced blood clotting time at 5.86, 5.52, and 5.01 min at 25, 50, and 100 mg/ml doses, respectively. In the assessment of the anthelmintic effect, SCE significantly killed Paramphistomum cervi (P. cervi) where the death times of the nematodes were 40.3, 36.8, and 29.9 min at 12.5, 25, and 50 mg/ml doses, respectively. The extract showed a very poor cytotoxic effect in brine shrimp lethality bioassay. In molecular docking analysis, maslinic acid, oleanolic acid, luteolin, luteolin 7-O-β-glucoside, myricetin, ellagic acid, and R-nyasol showed the best binding affinities with the selected proteins which might be the credible reasons for eliciting pharmacological responses. Among these seven compounds, only luteolin 7-O-β-glucoside had two violations in Lipinski’s rule of five.

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Section: Discussionmentioning

confidence: 99%

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

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“…17 and CNS depressant activity. 27 The leaf of F. racemosa used for synthesis of zinc oxide NPs (ZnO NPs) and it showed the good antibacterial activity on both Gram positive as well as Gram negative bacteria. 28 The stem sample was cleaned with distilled water before grinding to remove medium components.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles by using Stem, Leaves and Fruits Extracts of Umber (Ficus racemosa)

D¹,

P²,

S³

et al. 2020

IJPI

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Objectives: In this study, silver nanoparticles (AgNPs) were synthesized using healthy plant parts like fruits, stem and leaves of Ficus racemosa. Methods: The collected plant samples were processed by cleaning, drying and grinding. Bioactive compounds were extracted by using Soxhlet extraction method. The 10mg of plant extract was added to 1mM AgNO 3 solution and incubated at 80°C for 3min. The UV-Vis spectroscopy was used for characterization of produced AgNPs. The synthesis process was optimized for pH (3 to 9), plant extracts conc. (0.5, 1, 2, 4 and 8mg/2ml), incubation temp. (50°C, 60°C upto 100°C) and silver salt conc. (0.125, 0.25, 0.50, 1.0 and 2mM). Finally the antimicrobial and seed germination ability of synthesized AgNPs was determined. Results: The λ max values were found to be 464.50nm, 422nm and 489nm for fruits, stem and leaves respectively. FTIR spectra of control and test were determined which showed the different functional groups in the synthesized AgNPs. The optimum pH (9, 8 and 8), plant extracts conc. (8, 4 and 8mg), incubation temp. (80°C, 90°C and 100°C) and silver salt conc. (2mM, 1.5mM and 2mM) for fruit, stem and leaves AgNPs were determined. The selective NPs showed notable antibacterial activity against Gram positive bacteria like S. equorum and B. subtilis and significant effect on wheat (Triticum aestivum L.) seed germination. Conclusion: The green synthesis process was found to be time saving and effective approach for the synthesis of the AgNPs from different plant parts. Produced NPs have potential applications in therapeutics and agriculture.

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In vivo CNS Activity of Methanolic Extract of Ficus racemosa Fruits in Experimental Animals

Cited by 2 publications

References 6 publications

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Green Synthesis of Silver Nanoparticles by using Stem, Leaves and Fruits Extracts of Umber (Ficus racemosa)

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