In Vivo Confocal Microscopy of Polymorphic Amyloid Degeneration and Posterior Crocodile Shagreen

Abstract

These cases are, to our knowledge, the first to report confocal microscopic findings in isolated polymorphic amyloid degeneration and combined polymorphic amyloid degeneration with posterior crocodile shagreen.

Confocal Microscopy After Descemet Stripping Endothelial Keratoplasty: A Case Report

“…18 Confocal microscopy has been shown after refractive surgery, 19-21 manual descemet stripping keratoplasty, 22 deep anterior lamellar keratoplasty, 23 corneal collagen cross-linking, 24 amniotic membrane transplantation, 25 and microscopic findings of corneal pathologies. [26][27][28][29] In our study, significant edema, at baseline, did not allow the endothelial analysis through specular microscopy; more information was observed by confocal scanning microscope (Fig. 1).…”

Retrospective study: Outcomes of ab interno Hydrus microstent with concomitant cataract surgery

“…• There have been rare reports of combined PAD with posterior crocodile shagreen 2,5. • Confocal Microscopy of PAD demonstrates discrete, punctate, highly reflective deposits in both anterior and posterior stroma.…”

“…• Polymorphic amyloid degeneration (PAD) is an exceedingly rare condition, with only a few reported cases in the literature. [1][2][3][4][5] • Histopathologic analysis of affected corneas demonstrates amorphous deep stromal amyloid deposits deposits that stain positively with Congo red stain and demonstrate apple-green birefringence under polarized light. 1 • PAD is a non-hereditary primary localized amyloidosis.…”

“…1 • PAD is a non-hereditary primary localized amyloidosis. 1,5 • It often presents in older patients, who tend to remain asymptomatic and without associated visual dysfunction. • To date, the nature and significance of these deposits has yet to be determined.…”