In vivo confocal Raman microscopic determination of depth profiles of the stratum corneum lipid organization influenced by application of various oils

Choe, ChunSik; Schleusener, Johannes; Lademann, Jürgen; Darvin, Maxim E.

doi:10.1016/j.jdermsci.2017.04.016

Cited by 48 publications

(46 citation statements)

References 71 publications

(110 reference statements)

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“…Noninvasive optical methods were employed to analyze the skin penetration of petrolatum and white mineral oil in human subjects (Stamatas et al 2008;Patzelt et al 2012;Choe et al 2014;Choe et al 2015;Choe et al 2017). Test substances were applied to the inner forearm, mainly at dermal loads of 2 mg/cm 2 .…”

Section: Dermal Absorption Of Moshmentioning

confidence: 99%

“…Petrolatum was exclusively detected on the skin surface. With confocal Raman microscopy, the penetration process can be monitored and the thickness of the horny layer can be determined without the use of a tracer dye (Stamatas et al 2008;Choe et al 2014;Choe et al 2015;Choe et al 2017). The stratum corneum of untreated forearm skin was measured to be 19.2 mm thick (Choe et al 2014;Choe et al 2015).…”

Section: Dermal Absorption Of Moshmentioning

confidence: 99%

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Mineral oil in food, cosmetic products, and in products regulated by other legislations

Pirow

Blume

Hellwig

et al. 2019

Critical Reviews in Toxicology

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For a few years, mineral oils and their potential adverse health effects have been a constant issue of concern in many regulatory areas such as food, cosmetics, other consumer products, and industrial chemicals. Analytically, two fractions can be distinguished: mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). This paper aims at assessing the bioaccumulative potential and associated histopathological effects of MOSH as well as the carcinogenic potential of MOAH for consumer-relevant mineral oils. It also covers the absorption, distribution, metabolism, and excretion of MOSH and MOAH upon oral and dermal exposures. The use and occurrence of consumerrelevant, highly refined mineral oils in food, cosmetics and medicinal products are summarized, and estimates for the exposure of consumers are provided. Also addressed are the challenges in characterizing the substance identity of mineral oil products under REACH. Evidence from more recent autopsy and biopsy studies, along with information on decreasing food contamination levels, indicates a low risk for adverse hepatic lesions that may arise from the retention of MOSH in the liver. With respect to MOAH, at present there is no indication of any carcinogenic effects in animals dermally or orally exposed to highly refined mineral oils and waxes. Such products are used not only in cosmetics but also in medicinal products and as additives in food contact materials. The safety of these mineral oilcontaining products is thus indirectly documented by their prevalent and long-term use, with a simultaneous lack of clinical and epidemiological evidence for adverse health effects.

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Section: Dermal Absorption Of Moshmentioning

confidence: 99%

Section: Dermal Absorption Of Moshmentioning

confidence: 99%

Mineral oil in food, cosmetic products, and in products regulated by other legislations

Pirow

Blume

Hellwig

et al. 2019

Critical Reviews in Toxicology

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“…For skin analysis not related to cancer, but to characterize depth profiles of stratum corneum, e.g., penetration studies of drugs or cosmetic products, in numerous cases a model 3510 Skin Composition Analyzer (River Diagnostics, Rotterdam, The Netherlands) was frequently employed. [74][75][76][77][78] An alternative miniaturized, confocal fiber optic probe intended to fit within the instrument channel of a standard medical endoscope, with a diameter of 2.8 mm, was developed by Day et al 36 It was optimized for the study of the carcinogenesis process of esophageal malignancy. The optical layout is related to the probe shown in Fig.…”

Section: Basic Raman Probe Setupsmentioning

confidence: 99%

In-vivo Raman spectroscopy: from basics to applications

et al. 2018

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For more than two decades, Raman spectroscopy has found widespread use in biological and medical applications. The instrumentation and the statistical evaluation procedures have matured, enabling the lengthy transition from ex-vivo demonstration to in-vivo examinations. This transition goes hand-in-hand with many technological developments and tightly bound requirements for a successful implementation in a clinical environment, which are often difficult to assess for novice scientists in the field. This review outlines the required instrumentation and instrumentation parameters, designs, and developments of fiber optic probes for the in-vivo applications in a clinical setting. It aims at providing an overview of contemporary technology and clinical trials and attempts to identify future developments necessary to bring the emerging technology to the clinical end users. A comprehensive overview of in-vivo applications of fiber optic Raman probes to characterize different tissue and disease types is also given.

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“…Furthermore, evaluations of intercellular lipids packing and ordering, and SC thickness are commonly performed using CRM [209][210][211][212][213][214], and include applications in skin ageing [211,212] and topical oils [209]. Eklouh-Molinier [211] combined CRM and cutometric data into a Partial Least-Squares (PLS) model in an attempt to profile spectral markers associated with ageing, and used this to create a "biological age" chart that mapped skin age based on its molecular state rather than its chronological age.…”

Section: Confocal Raman Microscopymentioning

confidence: 99%

Review of Modern Techniques for the Assessment of Skin Hydration

Qassem

Kyriacou

2019

Cosmetics

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Skin hydration is a complex process that influences the physical and mechanical properties of skin. Various technologies have emerged over the years to assess this parameter, with the current standard being electrical probe-based instruments. Nevertheless, their inability to provide detailed information has prompted the use of sophisticated spectroscopic and imaging methodologies, which are capable of in-depth skin analysis that includes structural and composition details. Modern imaging and spectroscopic techniques have transformed skin research in the dermatological and cosmetics disciplines, and are now commonly employed in conjunction with traditional methods for comprehensive assessment of both healthy and pathological skin. This article reviews current techniques employed in measuring skin hydration, and gives an account on their principle of operation and applications in skin-related research.

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In vivo confocal Raman microscopic determination of depth profiles of the stratum corneum lipid organization influenced by application of various oils

Cited by 48 publications

References 71 publications

Mineral oil in food, cosmetic products, and in products regulated by other legislations

Mineral oil in food, cosmetic products, and in products regulated by other legislations

In-vivo Raman spectroscopy: from basics to applications

Review of Modern Techniques for the Assessment of Skin Hydration

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