In vivo cough suppressive activity of pectic polysaccharide with arabinogalactan type II side chains of Piper nigrum fruits and its synergistic effect with piperine

Khawas, Sadhana; Nosálóvá, G; Majee, Sujay Kumar; Ghosh, Kanika; Raja, Washim; Sivová, Veronika; Ray, Bimalendu

doi:10.1016/j.ijbiomac.2017.02.093

Cited by 29 publications

(11 citation statements)

References 32 publications

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“…The histopathological section of nasal mucosa showed the attenuation of redness and disruption of alveoli and bronchioles [ 167 ]. The antitussive activities of plant extracts containing piperine showed the good enhancement of the antitussive effect [ 168 ]. The inhibition of tumor growth in the lungs (B16F-10 melanoma cells) was observed after administration of piperine in the mice.…”

Section: Some Promising Natural Products and Their Pharmacologymentioning

confidence: 99%

Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations

Timalsina

Pokhrel

Bhusal

2021

BioMed Research International

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Respiratory inflammation is caused by an air-mediated disease induced by polluted air, smoke, bacteria, and viruses. The COVID-19 pandemic is also a kind of respiratory disease, induced by a virus causing a serious effect on the lungs, bronchioles, and pharynges that results in oxygen deficiency. Extensive research has been conducted to find out the potent natural products that help to prevent, treat, and manage respiratory diseases. Traditionally, wider floras were reported to be used, such as Morus alba, Artemisia indica, Azadirachta indica, Calotropis gigantea, but only some of the potent compounds from some of the plants have been scientifically validated. Plant-derived natural products such as colchicine, zingerone, forsythiaside A, mangiferin, glycyrrhizin, curcumin, and many other compounds are found to have a promising effect on treating and managing respiratory inflammation. In this review, current clinically approved drugs along with the efficacy and side effects have been studied. The study also focuses on the traditional uses of medicinal plants on reducing respiratory complications and their bioactive phytoconstituents. The pharmacological evidence of lowering respiratory complications by plant-derived natural products has been critically studied with detailed mechanism and action. However, the scientific validation of such compounds requires clinical study and evidence on animal and human models to replace modern commercial medicine.

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Section: Some Promising Natural Products and Their Pharmacologymentioning

confidence: 99%

Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations

Timalsina

Pokhrel

Bhusal

2021

BioMed Research International

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“…Recently, the physicochemical properties of rasam have been reported (8). As a part of our chemical investigation in rasam, curcumin, piperine and capsaicin were chosen as marker compounds based on their literature for exhibiting potent activity against upper and lower respiratory tract infections (URTI & LRTI) (9)(10)(11)(12)(13). The current work was planned to identify and quantify curcumin, piperine and capsaicin simultaneously by HPTLC in rasam.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of Curcumin, Piperine and Capsaicin by HPTLC in Rasam, a polyherbal soup

Panseriya¹,

MK²

2022

IJAM

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Traditionally rasam is consumed for the treatment of cold and cough. The major chemical constituents present in the spices required to prepare the rasam are known but, the chemical composition of the prepared rasam are unknown. The preparation involves, boiling the spices in water and oil, this may create an opportunity for an altered chemical profile of the prepared rasam. As a part of our chemical investigation in rasam, curcumin, piperine and capsaicin were chosen as marker compounds based on their literature for exhibiting potent activity against upper and lower respiratory tract infections (URTI & LRTI). The current work was planned to identify and quantify curcumin, piperine and capsaicin simultaneously by HPTLC in rasam. Silica gel 60F254 TLC plates were used for the study. The optimized mobile phase used was toluene and ethyl acetate (7:3, v/v) and the densiometric scanning was done at 254 nm. The Rf values of curcumin, piperine and capsaicin were found to be 0.26, 0.40 and 0.47 respectively. The calibration graph of peak area versus concentration graph of curcumin, piperine and capsaicin was found to be linear in the range of 2 to 7 μg spot-1. The amount of curcumin, piperine and capsaicin in 100 mL of rasam was found to be 0.49, 0.66 and 0.41% w/v respectively. The developed method was validated as per ICH guideline parameters. The current study shows that the developed TLC method is simple, precise, specific, robust and accurate. This method will also be useful to identify or quantity any polyherbal formulation containing curcumin, piperine and capsaicin as chemical constituents.

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“…However, pectin has attracted much interest in recent years as a fermentable dietary fiber that stimulates the growth of intestinal microorganisms (Vanitha & Khan, 2019). It indirectly confers health benefits through colonic fermentation by the gut microorganism, which releases a wide range of metabolites and exhibits numerous health‐promoting properties, including anticancer, gut, and immune‐modulating properties (Khan et al, 2013; Prado et al, 2019), anti‐adhesion effect against pathogens (such as Escherichia coli , Campylobacter jejuni , and Salmonella typhimurium ), analgesic effects (Khawas et al, 2017), antidiabetic properties (Wu et al, 2019), and anti‐inflammatory activity (Li et al, 2019). Some pectin interacts directly with pattern recognition receptors, such as Toll‐like receptors 2 and 4 or galectin‐3 (Beukema et al, 2020), and stimulates the gastrointestinal and immune barrier.…”

Section: Introductionmentioning

confidence: 99%

Low methoxy feruloylated pectin from beetroot: Antioxidant and prebiotic properties

sonale

Saarika‐PK

Sori

et al. 2022

Food Processing Preservation

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Pectin was extracted from beetroot pulp by acid hydrolysis using two concentrations of acid, 0.05 M and 0.1 M HCl and designated BRP1 and BRP2, respectively. CHNS, FTIR, and DSC analyses confirmed the purity and characterized it as a low methoxyl (LM) pectin. DPPH (%) inhibition was 22 and 11 for BRP1 and BRP2 and antioxidant activity determined by FRAP assay was 51 μM TE/g and 15 μM TE/g for BRP1 and BRP2, respectively. BR pectin significantly (p ≤ .05) stimulated the growth of Limosilactobacillus fermentum compared with citrus pectin. The highest prebiotic activity score (0.75) was observed for BRP1, followed by BRP2 (0.66), BR pulp (0.26), and citrus pectin (0.09). In addition, L. fermentum produced a higher amount of SCFA with BRP1 and BRP2 compared to the control. These results confirmed the bioactive and health‐promoting potential of BR pectin and hence can be used as an effective bioactive ingredient for various functional foods. Novelty impact statement Extraction of low methoxy pectin was investigated using two different concentrations of acid. Structural and functional properties of pectin were influenced by acid extraction conditions. Both pectins contain feruloylated sugars that contribute to their antioxidant properties L. fermentum produced the highest amount of acetate with BRP1, whereas the highest amount of propionic acid and butyric acid was produced with BRP2.

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In vivo cough suppressive activity of pectic polysaccharide with arabinogalactan type II side chains of Piper nigrum fruits and its synergistic effect with piperine

Cited by 29 publications

References 32 publications

Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations

Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations

Simultaneous quantification of Curcumin, Piperine and Capsaicin by HPTLC in Rasam, a polyherbal soup

Low methoxy feruloylated pectin from beetroot: Antioxidant and prebiotic properties

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