2023
DOI: 10.3390/ijms24021602
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In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance

Abstract: This study aimed to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy that enables the composite electrolytes to create a coating with better corrosion resistance and solve the problems of uneven and excessive degradation. A magnesium alloy bone screw made in this way was able to promote the bone healing reaction after implantation in rabbits. Additi… Show more

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Cited by 13 publications
(5 citation statements)
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“…41 There are several mechanisms of Mg implant degradation in vivo. 42,43 These include electrochemical corrosion, hydroxide and hydrogen formation, and chloride attack. The hydrogen that evolved can accumulate as gas bubbles within the defect area, causing serious clinical problems.…”
Section: Biodegradation Of Mgca Implants Within Bone Defects Are Fine...mentioning
confidence: 99%
“…41 There are several mechanisms of Mg implant degradation in vivo. 42,43 These include electrochemical corrosion, hydroxide and hydrogen formation, and chloride attack. The hydrogen that evolved can accumulate as gas bubbles within the defect area, causing serious clinical problems.…”
Section: Biodegradation Of Mgca Implants Within Bone Defects Are Fine...mentioning
confidence: 99%
“…Degradability is the preferred choice for temporary implant support in bone healing, such as plates and screws, thus eliminating unnecessary surgical risks and excessive costs for a second surgery [ 58 ]. Currently, magnesium (Mg), Fe, and zinc (Zn) alloys are the best biodegradable metals for orthopedics because they have good in vivo biocompatibility, controlled degradation profiles, and sufficient mechanical strength to support bone during regeneration [ [59] , [60] , [61] , [62] ]. The mechanical properties of biomedical metal materials and natural human bone are listed in Fig.…”
Section: Metal Materialsmentioning
confidence: 99%
“…3 and Table 2 .
Figure 3 Properties of 3D printing metal materials (A) Stainless steel [ 51 ], (B) Titanium alloy [ 52 ], (C) Cobalt-chromium alloy [ 53 ], (D) Tantalum alloy [ 52 ], (E) Shape memory alloy [ 54 ], (F) Zinc alloy [ 60 ], (G) Iron alloy [ 61 ], (H) Magnesium alloy [ 62 ], reproduced with permission.
…”
Section: Metal Materialsmentioning
confidence: 99%
“…Micro arc oxidation (MAO) is a common and mature surface treatment method for forming functionalized coatings with good physical, chemical, and biological properties on metal substrates. , MAO pretreatment of a magnesium substrate can form a high-quality MgO ceramic coating, strengthening the interface bonding between the coatings and metal substrates and improving corrosion resistance of the substrates. , In this study, we combined DCPD self-healing coatings with MAO to form biodegradable magnesium with excellent osteoinduction capabilities and corrosion resistance. Double-passivated treatment of the MAO and DCPD coatings (Mg-MAO/DCPD) exhibited mild preparation conditions and effectively maintained the integrity of the magnesium substrates.…”
Section: Introductionmentioning
confidence: 99%