1998
DOI: 10.1038/sj.onc.1201625
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In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

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Cited by 52 publications
(29 citation statements)
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“…Unlike the cadherin-associated b-catenin, the cytosolic b-catenin is known to be the sole pool that is tyrosine phosphorylated in the cell. Recent studies demonstrate that tyrosine phosphorylation of b-catenin is correlated with tumor formation and invasiveness (Sommers et al, 1994;Bonvini et al, 2001). We have already reported that in in vitro NIH3T3 cells the level of cytoplasmic bcatenin is negatively influenced by LMW-PTP expression (Taddei et al, 2002).…”
Section: Epha2 Is the Tyrosine Phosphorylated Substrate Of Lmw-ptp Inmentioning
confidence: 99%
“…Unlike the cadherin-associated b-catenin, the cytosolic b-catenin is known to be the sole pool that is tyrosine phosphorylated in the cell. Recent studies demonstrate that tyrosine phosphorylation of b-catenin is correlated with tumor formation and invasiveness (Sommers et al, 1994;Bonvini et al, 2001). We have already reported that in in vitro NIH3T3 cells the level of cytoplasmic bcatenin is negatively influenced by LMW-PTP expression (Taddei et al, 2002).…”
Section: Epha2 Is the Tyrosine Phosphorylated Substrate Of Lmw-ptp Inmentioning
confidence: 99%
“…Transcriptional response to stress signals like proteasome inhibitor treatment is a complex process (Palombella et al, 1994;Ichihara and Tanaka, 1995;Firestein and Feuerstein, 1998;Hofmann et al, 1996;Bonvini et al, 1998) with the response of many genes being dependent on crosstalk between signal transduction pathways and cell type speci®c factors.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, drugs of the GA class can reduce the expression of several tyrosine kinase and serine kinase oncogene products, including Her2, Met, Raf, cdk4, and Akt (Schulte and Neckers, 1998;Webb et al, 2000;Ochel et al, 2001;Blagosklonny, 2002;Solit et al, 2002). These drugs act at concentrations in the nanomolar range (nM-GAi) by inhibiting the molecular chaperone HSP90, thereby preventing proper folding of the client oncoproteins, leading to their destabilization (Webb et al, 2000;Bonvini et al, 2001;Ochel et al, 2001).…”
Section: Introductionmentioning
confidence: 99%