In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography

Klatt, Dieter; Asbach, Patrick; Rump, Jens; Papazoglou, Sebastian; Somasundaram, Rajan; Modrow, Jens; Braun, Jürgen; Sack, Ingolf

doi:10.1097/01.rli.0000244341.16372.08

Cited by 110 publications

(97 citation statements)

References 32 publications

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“…shear waves) are waves with motion perpendicular to their propagating direction. The generated shear waves observed here had bilateral directivities, as has been observed by other researchers (25,(28)(29)(30)(31), and did not propagate simply along two parallel straight lines. Instead, they were prone to deviate from the center axis and formed a biased diffraction field.…”

Section: Analysis Of the Shear Wave Fieldsupporting

confidence: 85%

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Diffraction-biased shear wave fields generated with longitudinal magnetic resonance elastography drivers

Yin

Rouvière

Glaser

et al. 2008

Magnetic Resonance Imaging

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Magnetic Resonance Elastography (MRE) is a technique for quantifying the acoustic response of biological tissues to propagating waves applied at low frequencies in order to evaluate mechanical properties. Application-specific MRE drivers are typically required to effectively deliver shear waves within the tissue of interest. Surface MRE drivers with transversely oriented vibrations have often been used to directly generate shear waves. These drivers may have disadvantages in certain applications, such as poor penetration depth and inflexible orientation. Therefore, surface MRE drivers with longitudinally oriented vibrations are used in some situations. The purpose of this work was to investigate and optimize a longitudinal driver system for MR elastography applications. It is shown that a cone-like hemispherical distribution of shear waves are generated by these drivers and the wave propagation is governed by diffraction in the near field. Using MRE visualization of the vector displacement field, the properties of the shear wave field created by longitudinal MRE drivers of various sizes were studied to identify optimum shear wave imaging planes. The results offer insights and improvements in both experimental design and imaging plane selection for 2-D MRE data acquisition.

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Section: Analysis Of the Shear Wave Fieldsupporting

confidence: 85%

“…The mean displacement amplitude and the mean shear stiffness (using the Direct Inversion algorithm (25,(28)(29)(30)(31)) were calculated in all shear wave images by using a standardized region of interest (square ROI, 20×20 pixels) positioned 15-mm below the driving surface.…”

Section: Dependence Of Wave Amplitude and Shear Stiffness On Imaging mentioning

confidence: 99%

Diffraction-biased shear wave fields generated with longitudinal magnetic resonance elastography drivers

Yin

Rouvière

Glaser

et al. 2008

Magnetic Resonance Imaging

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“…These include 1) a freely oriented field of view, 2) no need for acoustical window in contrast to transient elastography, 3) compatibility with many other receive coils such as multi-channel phased array torso coil, 4) operator independence, 5) insensitivity to body habitus, 6) the ability to obtain a conventional MR examination at the same time (27)(28)(29), and 7) potential to assess the entire liver with an appropriate rapid multislice method, as echo-planar MR Elastography (42). Thus, this technique provides an overall estimate rather than a narrow sliver obtained with ultrasound transient elastography or liver biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…MR Elastography can be readily implemented on standard MR imaging systems with little additional hardware (21). To date, MR Elastography has been applied to quantitatively assess the viscoelastic properties of many human tissues in vivo, including breast, brain, muscle, and liver (22)(23)(24)(25)(26)(27)(28)(29). Preliminary studies in human subjects have confirmed the feasibility and promise of this technique for the quantitative assessment of hepatic fibrosis (27,28).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

855

809

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Background & Aims-Accurate detection of hepatic fibrosis is crucial for assessing prognosis and candidacy for treatment in patients with chronic liver disease. Magnetic Resonance (MR) Elastography, a technique for quantitatively assessing the mechanical properties of soft tissues, has previously been shown to have potential for non-invasively detecting liver fibrosis. The goal of this work was to obtain preliminary estimates of the sensitivity and specificity of the technique in diagnosing liver fibrosis, and to assess its potential for identifying patients who can potentially avoid biopsy.

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“…For this reason, the accuracy of MRE potentially outperforms that of other modalities with anisotropic motion estimation. However, MRE still suffers from uncertainty regions in elastograms, which have to be masked in order to avoid biased stiffness estimates [16,17]. Such artifacts are mainly due to the strong impact of boundaries and tissue interfaces on the appearance of wave fields including non-evanescent waves, wave nodes, and amplitude modulations deviating from ideal wave models implied by the majority of inversion routines.…”

mentioning

confidence: 99%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

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Purpose: To introduce a novel in-vivo three-dimensional multifrequency magnetic resonance elastography (3D-MMRE) method for high-resolution mechanical characterization of the liver and spleen. Materials and Methods: Ten healthy volunteers were examined by abdominal single-shot 3D-MMRE using a novel patient-activated trigger system with respiratory control. 10 contiguous slices with 2.5?mm cubic voxel resolution, 3 wave components, 8 time steps, and 2 averages were acquired at 7 mechanical excitation frequencies from 30 to 60?Hz. The total imaging time was approximately 15?min. For postprocessing, multifrequency dual elasto-visco (MDEV) inversion was used to calculate high-resolution mechanical parameter maps of the abdomen including the liver and spleen. Results: Two parameters maps were generated from each image slice to capture the magnitude and the phase angle of the complex shear modulus. Both parameters depicted the mechanical structures of the abdomen with unprecedented high spatial resolution. Spatially averaged group mean values of the liver and spleen are 1.27???0.17 kPa and 2.01???0.69 kPa, indicating a significantly higher asymptomatic stiffness of the spleen compared to the liver. Conclusion: Patient-activated respiratory-gated 3D-MMRE combined with MDEV inversion provides highly resolved mechanical maps of the liver and spleen that are superior to previous elastograms measured by abdominal MRE. Citation Format: ??Guo J, Hirsch S, Streitberger KJ et?al. Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen. Fortschr R?ntgenstr 2014; 186: 260???266

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In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography

Cited by 110 publications

References 32 publications

Diffraction-biased shear wave fields generated with longitudinal magnetic resonance elastography drivers

Diffraction-biased shear wave fields generated with longitudinal magnetic resonance elastography drivers

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

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