2023
DOI: 10.21203/rs.3.rs-2842420/v1
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In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water

Abstract: In vivo deuterated water (2H2O) labeling leads to deuterium (2H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer cells would become preferentially labeled with 2H and, therefore, could be visualized by deuterium magnetic resonance imaging (dMRI) following a brief period of in vivo systemic 2H2O administration. We initiated systemic 2H2O administration in two xenograft mouse models harboring ei… Show more

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