In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots

Su, Yuanyuan; Peng, Fei; Jiang, Zaiyong; Zhong, Yiling; Lu, Yujie; Jiang, Xingxing; Huang, Qing; Fan, Chunhai; Lee, Shuit‐Tong; He, Yao

doi:10.1016/j.biomaterials.2011.04.063

Cited by 176 publications

(136 citation statements)

References 36 publications

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“…S4C). Hepato-renal toxicity is a well-known issue preventing the approval of QDs for biomedical applications, and the observed damage is likely attributed to the leakage of the QDs out of the LbL shell (34,35). To our knowledge, this is the first report of the head-to-head comparison of toxicities of NIR-II probes in an identical LbL platform.…”

Section: Resultsmentioning

confidence: 92%

Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer

Dang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

174

133

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Fluorescence imaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes, are constructed into biocompatible nanoparticles using the layer-bylayer (LbL) platform due to its modular and versatile nature. The LbL platform has previously been demonstrated to enable incorporation of diagnostic agents, drugs, and nucleic acids such as siRNA while providing enhanced blood plasma half-life and tumor targeting. This work carries out head-to-head comparisons of currently available NIR-II probes with identical LbL coatings with regard to their biodistribution, pharmacokinetics, and toxicities. Overall, rare-earth-based down-conversion nanoparticles demonstrate optimal biological and optical performance and are evaluated as a diagnostic probe for high-grade serous ovarian cancer, typically diagnosed at late stage. Successful detection of orthotopic ovarian tumors is achieved by in vivo NIR-II imaging and confirmed by ex vivo microscopic imaging. Collectively, these results indicate that LbL-based NIR-II probes can serve as a promising theranostic platform to effectively and noninvasively monitor the progression and treatment of serous ovarian cancer.second near-infrared window | layer by layer | systemic comparison | ovarian tumor detection | deep penetration

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Section: Resultsmentioning

confidence: 92%

Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer

Dang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

174

133

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“…They found that the biodistribution was largely dependent on hydrodynamic diameters of the QDs, blood circulation time, and types of organs. Based on histological and biochemical quantitative analysis, and real-time body weight measurement, we further revealed that, the aqQDs produced no overt adverse effect to mice [28]. These studies are important for understanding the in vivo toxicity of QDs, and for designing QDs with acceptable biocompability for biomedical applications.…”

Section: Biosafety Assessment Of Ii-vi Qdsmentioning

confidence: 72%

Quantum Dots-Based Biological Fluorescent Probes for In Vitro and In Vivo Imaging

He¹

2012

Quantum Dots - A Variety of New Applications

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“…Potential effects on the lungs include damage to membranes, cytotoxicity, genotoxicity, apoptosis (induced programmed cell death), necrosis (cell death due to toxic interference with vital cell functions), inflammation, fibrosis, and cancer [1-3, and references therein]. Inhaled nanoparticles may penetrate the alveolar-capillary barrier between the respiratory and circulatory system, and thus be translocated from the lungs [2,3,[30][31][32][33][34][35][36][37][38][39][40][41][42], and references therein]. When the nanoparticles translocate to the circulatory system, other organs may also be affected [1-3, 15, 16, 30-32, 39-42].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

“…For instance, as pointed out before, Choi et al [39] found that noncationic nanoparticles \34 nm were rapidly translocated from the lungs, whereas cationic nanoparticles of a similar size were not. The generation of Ag ions by silver nanoparticles [82] and the release of ionic Cd and Se from CdSe quantumdots [16,36,84,85] are determinants of nanoparticle hazard. Metal solubility has been found a determinant in cytotoxicity of metal oxide and metal hydroxide nanoparticles [19,86].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

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Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

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In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots

Cited by 176 publications

References 36 publications

Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer

Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer

Quantum Dots-Based Biological Fluorescent Probes for In Vitro and In Vivo Imaging

Human health hazards of persistent inorganic and carbon nanoparticles

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