2009
DOI: 10.1016/j.neuroscience.2009.03.083
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In vivo dopamine release and uptake impairments in rats treated with 3-nitropropionic acid

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Cited by 34 publications
(33 citation statements)
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“…Although technologies already exist for the continuous or near-continuous measurement of a small number of metabolites [e.g., glucose (2) and lactate (3)] and neurotransmitters [e.g., dopamine (4,5), serotonin (6), glutamate (7), and acetylcholine (8)] in vivo, these approaches all rely on the specific chemical reactivities of their targets (e.g., the redox chemistry of the analyte or its ability to be oxidized by a specific enzyme). Because of their dependence on reactivity, these technologies are not generalizable to the detection of many other physiologically or clinically important molecules, and there remains an open, critical need for strategies that support the continuous detection of specific molecules in the body irrespective of their reactivity.…”
mentioning
confidence: 99%
“…Although technologies already exist for the continuous or near-continuous measurement of a small number of metabolites [e.g., glucose (2) and lactate (3)] and neurotransmitters [e.g., dopamine (4,5), serotonin (6), glutamate (7), and acetylcholine (8)] in vivo, these approaches all rely on the specific chemical reactivities of their targets (e.g., the redox chemistry of the analyte or its ability to be oxidized by a specific enzyme). Because of their dependence on reactivity, these technologies are not generalizable to the detection of many other physiologically or clinically important molecules, and there remains an open, critical need for strategies that support the continuous detection of specific molecules in the body irrespective of their reactivity.…”
mentioning
confidence: 99%
“…DA plays roles in reward, 26 cognition, 27 and locomotor control. 27 Alterations in DA system function have been observed in response to chemically induced oxidative insult, 28 genetic modifications that model oxidative stress, 29 and neurodegenerative disease. 28,3035 Serotonin (5-HT) has been implicated in mood and cognition, as well as other neurological functions.…”
mentioning
confidence: 99%
“…DA and 5-HT play roles in reward (Schultz, 2002), cognition and locomotor control (Bäckman et al, 2006). Alterations in their system function have been observed in response to genetic modifications that model oxidative stress (Ortiz et al, 2011 andKita et al, 2003) and neurodegenerative disease (Eisenberger et al, 1986;Morgan et al, 1987;Kita et al, 2003;Kraft et al, 2009and Ortiz et al, 2010. Serotonin has been shown to suppress excitatory synaptic transmission (Schmitz et al, 1999).…”
Section: Discussionmentioning
confidence: 99%