In vivo effect of aluminium upon the physical properties of the erythrocyte membrane

Bazzoni, Graciela; Bollini, A; Hernández, G.; Contini, María del Carmen; Chiarotto, Marcelo M; Rasia, M.

doi:10.1016/j.jinorgbio.2004.12.012

Cited by 27 publications

(25 citation statements)

References 27 publications

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“…In contrast to our observation, Bazzoni et al found that the osmotic fragility of erythrocyte was down-regulated in rat i.p. with Al hydroxide [27]. The different conclusion may be related to the different exposure scheme such as the form and dose of Al.…”

Section: Discussionmentioning

confidence: 96%

“…Erythrocyte membrane is one of the main target tissues for Al toxicity [26][27][28]. Several studies reported that Al damages the molecular structure, deformability, and fluidity of erythrocyte membrane by inducing lipid peroxidation and oxidative stress [27,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies reported that Al damages the molecular structure, deformability, and fluidity of erythrocyte membrane by inducing lipid peroxidation and oxidative stress [27,[29][30][31]. Moreover, Suwalsky et al found that Al disorders the ion balance between intracellular and extracellular, which affects the transport function of membrane [32].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Zhang

Cao

Sun

et al. 2015

Biol Trace Elem Res

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Aluminum (Al) is the most abundant metal in the earth's crust. Al accumulates in erythrocyte and causes toxicity on erythrocyte membrane. The dysfunction of erythrocyte membrane is a potential risk to hypertension. The high Al content in plasma was associated with hypertension. To investigate the effect of AlCl3 on blood pressure and the function of erythrocyte membrane, the rats were intragastrically exposed to 0, 64(1/20 LD50), 128(1/10 LD50), and 256(1/5 LD50) mg/kg body weight AlCl3 in double distilled water for 120 days, respectively. Then, we determined the systolic and mean arterial blood pressures of rats, the osmotic fragility, the percentage of membrane proteins, the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-pX), and malondialdehyde (MDA) content of the erythrocyte membrane in this experiment. The results showed that AlCl3 elevated the systolic and mean arterial blood pressure of rats, increased the osmotic fragility, decreased the percentage of membrane protein, inhibited the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, CAT, SOD and GSH-pX, and increased the MDA content of erythrocyte membrane. These results indicate that AlCl3 may induce hypertension by disturbing the function of erythrocyte membrane.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Zhang

Cao

Sun

et al. 2015

Biol Trace Elem Res

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“…In our study, we noted a negative correlation between IgE, MPO and Fe levels in non-smoking smelters, while dislocation of iron in chronic inflammation may be an additional factor affecting serum transferrin iron level [81] (Table 4). Al affects various stages of heme biosynthesis by changing the activity of some enzymes [82][83][84][85], iron metabolism [86][87][88][89] or disrupting erythrocyte membrane [90]. Linear regression analysis (Table 5), eliminating the effects of respective confounding factors (e.g., age, tobacco smoking) shows that CC16 and Al-S correlation was very strong (p = 0.006).…”

Section: Ijomeh 2006;19(4)mentioning

confidence: 99%

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Hałatek¹,

Trzcinka-Ochocka²,

Matczak³

et al. 2006

International Journal of Occupational Medicine and Environmental Health

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Objectives: Although some of the exposures in aluminum (Al) smelting have been well characterized, and respiratory disorders in aluminum production workers are well known, the relationship between internal aluminum loads and appropriate lung biomarkers have not been elucidated. The aim of our work was to carry out a comprehensive investigation in workers employed in the Aluminum Foundry Casting Department with special reference to currently existing hygiene standards, known as threshold limit values (TLV) based on aluminum effects on the respiratory system. The measurement of serum anti-inflammatory Clara cell protein (CC16) was employed as a peripheral marker of the lung epithelium function. Materials and Methods: A group of 50 casting smelters, 5 locksmiths, 11 sawyers and auxiliary workers exposed to dust containing 14% of aluminum, and a group of 42 controls were examined. Respiratory function tests were performed and forced volume capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), forced expiratory volume in the first percent (FEV 1 %), forced expiratory flows in 50% VC (FEV 50 ), and markers of foundry workers' exposure and body burden, Al concentration in the breathing zone, blood and urine, biomarkers of the effects of exposure, concentration of CC16 and hyaluronic acid (HA) in serum were determined in all examined workers. Additional measurements comprised determinations of serum iron (Fe) levels, myeloperoxidase (MPO), eosinophil cationic protein (ECP), immunoglobulin E (IgE), glutathione S-transferase (GST), and superoxide dismutase (SOD) activity in erythrocytes. Results: The group of casting smelters was characterized by the highest levels of aluminum in urine (Al-U) (43.7 mg L -1 ), high levels of MPO, ECP and IgE, high SOD activity, low CC16 levels, and low activity of GST. Lower Al-U excretion was observed in locksmiths (35.2 mg L -1 ) and sawyers (21.7 mg L -1 ). Serum CC16 proved to be the most sensitive biomarker, showing high inverse relationship with serum Al (Al-S) concentrations in casting smelters (p = 0.006). Conclusions: The study showed that in conditions of occupational exposure, dusts containing Al 2 O 3 < 1 mg m -3 cause changes in the respiratory system and biomarkers in serum, especially in CC16, connected with altered functioning of this system. Changes in concentrations of the examined biomarkers and also in respiratory parameters of the study subjects were observed when Al-U concentration was > 40 mg L -1 .

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“…Aluminum, the most abundant metal in the Earth's crust, is used in multiple anthropogenic activities. Its biologic importance is unclear and several authors have reported toxic effects elicited in different animal models (Bazzoni et al 2005;Lankoff et al 2006;Stacchiotti et al 2006;Ward et al 2006). Al is neurotoxic to various species, including fish, whose brain tissue histopathology has been found to be closely similar to that of humans exposed to this metal and suffering from Alzheimer's disease (Exley 1996).…”

Section: Introductionmentioning

confidence: 99%

Aluminum-induced oxidative stress in lymphocytes of common carp (Cyprinus carpio)

García-Medina

Razo-Estrada

Gómez-Oliván

et al. 2009

Fish Physiol Biochem

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Several studies of fish have shown that aluminum may induce hypoxia, hypercapnia, metabolic acidosis, and respiratory failure. In lymphocytes, morphologic abnormalities and reduced immune activity have been observed. Nevertheless, there is little data on oxidative stress and such data are essential in order to identify its mechanism of action. The common carp Cyprinus carpio, an omnivorous fish commonly used in commercial aquaculture, has been proposed as a test organism in toxicologic assays due to its economic importance and wide geographic distribution. The aim of this work was to evaluate Al-induced oxidative stress in lymphocytes of the common carp C. carpio. Specimens were exposed to three different concentrations of Al (0.05, 120, and 239 mg/l) in a static exposure system for 96 h. At the end of the exposure period, blood was collected and lymphocytes were separated. Lipid peroxidation, oxidized protein content and the activity of superoxide dismutase, catalase, and glutathione peroxidase were measured. Results show that the tested Al concentrations modified the activity of antioxidant enzymes and elicited higher levels of lipid peroxidation and oxidized proteins. The degree of damage induced was concentration and tissue dependent.

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In vivo effect of aluminium upon the physical properties of the erythrocyte membrane

Cited by 27 publications

References 27 publications

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Aluminum-induced oxidative stress in lymphocytes of common carp (Cyprinus carpio)

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