In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2+-ATPases from hypercholesterolemic rats

Marques, Emiliana Barbosa; Motta, Nadia Alice Vieira; Kümmerle, Arthur Eugen; Fraga, Carlos A.M.; Barreiro, Eliezer J.; Brito, Fernanda; Scaramello, Christianne Brêtas Vieira

doi:10.1016/j.ijcard.2015.08.091

Cited by 1 publication

(2 citation statements)

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“…They are useful instruments to predict coronary artery disease risk in daily practice, especially in people with other risk factors. 21,24,39 Leptin serum levels have also increased in early-weaned male rats upward postnatal day 150. Usually, leptin increases the expression of neuropeptides associated with food intake inhibition.…”

Section: Discussionmentioning

confidence: 99%

“…Lipid profile was determined using a commercially available Labtest Brasil kit. 21 Friedewald equation 22 was applied to calculate low-density lipoproteins cholesterol (LDL-c) and very low-density lipoproteins cholesterol (VLDL-c) concentrations. The ratio of total cholesterol and high-density lipoproteins cholesterol (HDL-c) levels gave the Castelli I index.…”

Section: Biochemical Analysismentioning

confidence: 99%

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Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning

Barros

Alvim-Silva

Souza

et al. 2020

J Dev Orig Health Dis

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Literature describes breast milk as the best food for the newborn, recommending exclusive breastfeeding for up to 6 months of age. However, it is not available for more than 40% of children worldwide. Pharmacological and non-pharmacological models of 3-day early weaning were developed in rodents to investigate later outcomes related solely to this nutritional insult. Thus, the present work aimed to describe biometric, nutritional, biochemical, and cardiovascular outcomes in adult male rats submitted to 3-day early weaning achieved by maternal deprivation. This experimental model comprises not only nutritional insult but also emotional stress, simulating mother abandoning. Male offspring were physically separated from their mothers at 21st (control) or 18th (early weaning) postnatal day, receiving water/food ad libitum. Analysis performed at postnatal days 30, 90, 150, and 365 encompassed body mass and food intake monitoring and serum biochemistry determination. Further assessments included hemodynamic, echocardiographic, and cardiorespiratory evaluation. Early-weaned males presented higher body weight when compared to control as well as dyslipidemia, higher blood pressure, diastolic dysfunction, and cardiac hypertrophy in adult life. Animals early deprived of their mothers have also presented a worse performance on the maximal effort ergometer test. This work shows that 3-day early maternal deprivation favors the development of cardiovascular disease in male rats.

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Section: Discussionmentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%