In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways

Bhattacharyya, Sambhu N.; Dubick, Michael A.; Yantis, Loudon D.; Enriquez, J.; Buchanan, Kelvin C.; Batra, Surinder K.; Smiley, Rebecca

doi:10.1023/b:ifla.0000033022.66289.04

Cited by 12 publications

(5 citation statements)

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“…An aberrant expression of MUC4 is also detected in human pancreatic tissues from cystic fibrosis patients as compared with the normal pancreas (81). In a recent study (82), transient up-regulation of Muc4 was observed in woodsmoke-treated rats during the recovery phase, suggesting yet another role of MUC4 in the renewal of tracheal epithelium. MUC4 is also aberrantly expressed in epithelial ovarian carcinomas, while exhibiting negligible expression in the normal ovary (83).…”

Section: Muc4 Expression In Malignancies and Inflammatory Diseasesmentioning

confidence: 93%

“…In general, all mucins play a role in the lubrication of epithelial surfaces and their protection from infections and injuries. Several lines of evidence implicate MUC4 in other important and more sophisticated biological processes as well, such as epithelial cell renewal and differentiation, cell signaling, cell adhesion, and cancer development (26,82,(85)(86)(87)(88).…”

Section: Multifaceted Functions Of the Muc4 Mucinmentioning

confidence: 99%

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Structure, evolution, and biology of the MUC4 mucin

2007

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Mucins are high-molecular-weight glycoproteins and are implicated in diverse biological functions. MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas. Among various potential domains of MUC4, epidermal growth factor (EGF) -like domains are hypothesized to interact with and activate the ErbB2 receptors, suggesting an intramembrane-growth factor function for MUC4. The heavily glycosylated tandem repeat domain provides the structural rigidity to the extended extracellular region. MUC4, by virtue of its extended structure, serves as a barrier for some cell-cell and cell-extracellular matrix interactions and as a potential reservoir for certain growth factors. An intricate relationship between MUC4 and growth factor signaling is also reflected in the transcriptional regulation of MUC4. The MUC4 promoter has binding sites for different transcription factors, which are responsible for the regulation of its expression in different tissues. The interferon-gamma, retinoic acid, and transforming growth factor-beta signaling pathways regulate MUC4 expression in a partially interdependent manner. Taken together, all of these features of MUC4 strongly support its role as a potential candidate for diagnostic and therapeutic applications in cancer and other diseases.

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Section: Muc4 Expression In Malignancies and Inflammatory Diseasesmentioning

confidence: 93%

Section: Multifaceted Functions Of the Muc4 Mucinmentioning

confidence: 99%

Structure, evolution, and biology of the MUC4 mucin

2007

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“…Wood smoke has adverse effects on surfactant48 and cilial function 49. To offset particle oxidative effects, epithelial lining fluid contains high levels of the antioxidant glutathione,50 which is up-regulated after exposure to wood smoke 51.…”

Section: Respiratory Infectionsmentioning

confidence: 99%

Respiratory risks from household air pollution in low and middle income countries

Gordon¹,

Bruce²,

Grigg³

et al. 2014

The Lancet Respiratory Medicine

775

592

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A third of the world’s population uses solid fuel derived from plant material (biomass) or coal for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple stove with incomplete combustion, and result in a large amount of household air pollution when smoke is poorly vented. Air pollution is the biggest environmental cause of death worldwide, with household air pollution accounting for about 3·5–4 million deaths every year. Women and children living in severe poverty have the greatest exposures to household air pollution. In this Commission, we review evidence for the association between household air pollution and respiratory infections, respiratory tract cancers, and chronic lung diseases. Respiratory infections (comprising both upper and lower respiratory tract infections with viruses, bacteria, and mycobacteria) have all been associated with exposure to household air pollution. Respiratory tract cancers, including both nasopharyngeal cancer and lung cancer, are strongly associated with pollution from coal burning and further data are needed about other solid fuels. Chronic lung diseases, including chronic obstructive pulmonary disease and bronchiectasis in women, are associated with solid fuel use for cooking, and the damaging effects of exposure to household air pollution in early life on lung development are yet to be fully described. We also review appropriate ways to measure exposure to household air pollution, as well as study design issues and potential effective interventions to prevent these disease burdens. Measurement of household air pollution needs individual, rather than fixed in place, monitoring because exposure varies by age, gender, location, and household role. Women and children are particularly susceptible to the toxic effects of pollution and are exposed to the highest concentrations. Interventions should target these high-risk groups and be of sufficient quality to make the air clean. To make clean energy available to all people is the long-term goal, with an intermediate solution being to make available energy that is clean enough to have a health impact.

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“…Some of the pulmonary outcomes that a lot of these studies were aimed at included airway reactivity (Barrett et al 2006;Bhattacharyya et al 2004;Hsu and Kou 2001), asthma exacerbation (Samuelsen et al 2008;Tesfaigzi et al 2005), pulmonary function or injury (Clark et al 1990;Dubick et al 2002;Hubbard et al 1991;Ischiropoulos et al 1994;Jeng et al 2003;Lin et al 2001;Park et al 2004;Steinberg et al 2005;Thorning et al 1982), effects on surfactant (Jeng et al 2003;, inflammation (Bhattacharyya et al 2004;Huang et al 2006), epithelial damage (Bhattacharyya et al 1998), edema Nieman et al 1995), apnea , and antibacterial activity (Fick et al 1984;Pimenta et al 2000). Extrapulmonary assessments have included effects on the cardiovascular system (Brizio-Molteni et al 1984), adjuvant activity (Samuelsen et al 2008 (Bhattacharyya et al 1998;Liang et al 1988;Mumford et al 1990).…”

Section: Parameters Assayedmentioning

confidence: 99%

Biomass smoke exposures: toxicology and animal study design

Migliaccio

Mauderly

2009

Inhalation Toxicology

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The International Biomass Smoke Health Effects (IBSHE) conference was convened in Missoula, MT, to define our current knowledge of smoke exposure and the potential health effects. In an effort to ascertain the relative health effects of an exposure to biomass smoke, numerous studies have utilized either animal or in vitro systems. A wide variety of systems that have been employed ranged from more mainstream animal models (i.e., rodents) and transformed cell lines to less common animal (piglets and dogs) and explant models. The Toxicology and Animal Study Design Workgroup at IBSHE was tasked with an analysis of the use of animal models in the assessment of the health effects of biomass smoke exposure. The present article contains a mini-review of models utilized historically, in addition to the adverse health effects assessed, and an overview of the discussion within the breakout session. The most common question that arose in discussions at the IBSHE conference was from local and federal health departments: What level of smoke is unhealthy? The present workgroup determined categories of exposure, common health concerns, and the availability of animal models to answer key health questions.

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In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways

Cited by 12 publications

References 50 publications

Structure, evolution, and biology of the MUC4 mucin

Structure, evolution, and biology of the MUC4 mucin

Respiratory risks from household air pollution in low and middle income countries

Biomass smoke exposures: toxicology and animal study design

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