This study aimed to analyze a novel technique to make screws with greater untightening resistance and to solve screw loosening in implant-supported single crowns. Thirty grade IV titanium straight abutments were screwed onto 30 external hex implants using grade IV titanium screws (30 Ncm). They were exposed to cyclic loading (300,000 cycles, 200 N). Samples were divided into 4 groups (15 samples per group): new screws (SCREW group) (control), reused screws (rSCREW group), new screws wrapped with polytetrafluoroethylene (PTFE) tape (PTFE group), and reused screws wrapped with PTFE tape (rPTFE group). Reverse torque values (RTVs) were recorded with a digitally calibrated implant motor. Mean RTVs observed were 14.46 N (±1.10 N) for the control group, 14.42 N (±1.22 N) for the rSCREW group, 19.97 N (±1.16 N) for the PTFE group, and 19.13 N (±2.38 N) for the rPTFE group. Statistically significant differences were found between RTVs of both groups employing screws without PTFE tape (SCREW and rSCREW groups) compared with those using screws wrapped with PTFE tape (PTFE and rPTFE) (p < 0.001). These results suggest that wrapping the implant–abutment screw with PTFE tape may effectively lower the risk of loosening and even constitute a solution when this complication occurs in implant single crowns.