In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption

Al-Mamary, Mohammed; Al‐Habori, Molham; Al-Aghbari, Abdulwali M.; Al-Obeidi, Abdulkarim

doi:10.1016/s0271-5317(01)00334-7

Cited by 93 publications

(67 citation statements)

References 28 publications

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“…Increased endogenous protein losses, primarily through increased mucus production (Sell et al, 1984) or CT complexation with digestive enzymes (Al-Mamary et al, 2001), is an often cited explanation for observed impairments in intestinal protein digestibility in both ruminants (Waghorn, 2008) and non-ruminants (Jansman, 1993). Orlandi et al (2015) reported a similar degree of N digestibility inhibition when calculated on an apparent basis and when the effect of endogenous losses was removed by utilizing only neutral detergent insoluble N as a proxy for N of dietary origin.…”

Section: Interactions Between Condensed Tannins and Protein In The Dietmentioning

confidence: 99%

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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-Tannins represent one of the most abundant polyphenolic compounds in plants. Tannins exist as a multitude of chemically unique entities in nature. The most commonly occurring tannins are typically divided into two major classes based on chemical structure: hydrolysable (HT) or condensed tannins (CT). Hydrolysable tannins are esters of gallic or ellagic acid linked to a polyol core, typically glucose. Condensed tannins or proanthocyanidins consist of flavan-3-ol subunits linked together to form oligomers and polymers. Both HT and CT are defined as astringent, medium-to-high-molecular weight polyphenolic compounds that characteristically bind and precipitate soluble proteins. The objective of this paper was to present recent advances in CT-ruminant interactions, the limitations associated with understanding and using CT in ruminant animal production, and future needs for research to further advance our knowledge of the role of CT in optimization of ruminant animal production. Condensed tannins pose some anti-nutritional problems to ruminants due to their astringent property that reduces feed intake and, consequently, animal performance. Ruminants can, however, tolerate CT by slowly adapting the ruminal microbes to the toxic effects of CT and by releasing CT-binding salivary proteins. The protein-binding ability of CT has some benefits to the ruminant due to complexes formed with essential amino acids, preventing their degradation in the rumen, but releasing them in the lower gut for absorption by the animal. Recent data have suggested increased N retention when CT is given to growing animals. There are potential benefits of using CT and HT for anthelmintic purposes due to their ability to inhibit egg hatching and larval motility of gastrointestinal nematode parasites, especially in small ruminants. Condensed tannins also bind to minerals (Al, Ca, Co, Cu, Fe, Mg, Mn, P, and Zn). Although studies with ruminants have been contradictory, it has been reported that because the CT-metal ion complex is stable over a wide pH range, CT may reduce the bioavailability of minerals. Methane mitigation by feeding CT might be the most impactful benefit for ruminant production. Many empirical equations have been developed to predict ruminal methane emissions, but very few have included CT. Future research should focus on the improvement of methodology to assess CT biological activity, interaction with other plant-specialized metabolites, and associated physiological and nutritional impacts on ruminants.

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Section: Interactions Between Condensed Tannins and Protein In The Dietmentioning

confidence: 99%

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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“…Several mechanisms have been proposed to explain this "anti-nutritional" effect as reviewed by Awika and Rooney. (10) These include: binding of proteins and carbohydrates into insoluble complexes that resist digestive enzyme breakdown; (112)(113)(114)(115) binding of digestive enzymes directly, inhibiting their enzymatic activity; (116,117) and inhibition of intestinal brush border bound amino acid transporters, (118) particularly by tannin sorghums with higher degrees of polymerization, (119) resulting in reduced digestive enzyme activity. These effects were also reflected in animal feeding trials that demonstrated the feeding efficiency of tannin sorghums was 5 to 10% lower than non-tannin sorghums, depending on the animal species, the method of grain processing and diet type.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…In general, animals consumed more feed yet experienced the same or slightly less weight gain when tannin sorghum formed the basis of their diets. (116,117,120) Such effects in a Western diet, where food is ubiquitous, may be beneficial if these results are to be translatable to humans. Antioxidant tannins may be key protective components in sorghum foods for the mitigation of oxidative stress-induced diseases, with anti-proliferative and anti-inflammatory effects as their key mechanisms of action.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…This postulation is partly based on evidence from numerous feeding studies that show animals (from rodents to livestock species) fed whole grain sorghum, in particular the slowly digested high tannin sorghum varieties, have reduced weight gain. (116,117,120,154,155) In general, dietary fiber and whole grain intakes have been associated with reduced risks of obesity, overweight and with lowered waist-to-hip ratio. (156,157) Effects of dietary fiber on appetite and satiety have been proposed as major mechanisms for these reductions.…”

Section: Effects On Energy Balancementioning

confidence: 99%

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Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Stefoska‐Needham

Beck

Johnson

et al. 2015

Food Reviews International

148

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“…(Shakoor et al, 2014) O sorgo destaca-se atualmente como o quinto cereal de maior produção no mundo, sendo uma alternativa ao consumo de cereais convencionais como arroz, milho, trigo e cevada. Como alimento, o sorgo apresenta vantagens devido à elevadas concentrações de compostos fenólicos que atuam como antioxidantes, contribuindo na redução de doenças cardiovasculares (Carr et al, 2005), diabetes (Lakshmi & Vimala, 1996), obesidade (Al-Mamary et al, 2001) e câncer Yang et al, 2009), além de apresentar grande quantidade de fibras alimentares, agregando valor nutricional (Awika et al, 2005). Ademais, o sorgo apresenta alta resistência ao estresse hídrico, respondendo de maneira mais eficiente ao cultivo sob essas condições quando comparado a outros cereais (Magalhães et al, 2000).…”

Section: Introductionunclassified

Cultura de células em suspensão como ferramenta para estudos em parede celular secundária em gramíneas C4

Simões¹

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Agradeço a Deus em primeiro lugar, pelas minhas conquistas, me fortalecendo nas adversidades e dificuldades, e renovando minhas forças a cada dia.Aos meus pais Márcia e José Helio, responsáveis pela formação do meu caráter e projeções profissionais, e por todo sacrifício que fizeram em prol dos meus estudos.Ao meu esposo Felipe M. Araújo, por estar sempre ao meu lado, me incentivando a crescer, principalmente me motivando nos momentos difíceis e por ser meu porto seguro. Por acreditar que eu era capaz e por se alegrar a cada nova conquista, a cada experimento. Por se preocupar com o andamento do meu trabalho, ainda que muitas vezes não entendesse os processos por trás dos experimentos montados, sempre se prontificando a me ajudar e acreditando que uma hora os resultados sairiam.Ao meu Orientador, Profº Dr. Igor Cesarino, pela orientação, pelas oportunidades concedidas, por todo o conhecimento e principalmente pela confiança depositada na realização do meu trabalho. Agradeço grandemente esse tempo de aprendizado que passei ao seu lado, por tudo que aprendi contigo, pela paciência, dedicação, carinho e em especial pelos trabalhos de chinesa grávida. Tenho grande admiração pelo profissional que você é.Aos amigos que conquistei, aos momentos de descontração e risada que tornaram essa caminhada muito mais leve e divertida. Em especial aos meus amigos, Giovanni Victório Cerruti, Bruno Viana Navarro, Amanda Macedo e Leandro Oliveira, os quais espero levar para o resto da vida.Ao grupo de pesquisa Lignin Lab, coordenado pelo meu orientador Profª Dr Igor Cesarino e composto pelos colegas de pesquisa Raphael Svartman, Gabriel Garon Carvalho. Em especial ao Pos Doc Sávio Siqueira Ferreira, pela dedicação, paciência e carinho com o qual me auxiliou e ajudou durante a realização do meu trabalho.A Profª Drª Eny Iochevet Segal Floh, responsável pelo laboratório de BioCel -USP, pelo acolhimento e carinho com o grupo de pesquisa o qual me encontro, pela concessão do espaço e equipamentos cedidos para a realização e execução do presente trabalho.A FAPESP, pela concessão da bolsa de mestrado (processo 2015/18361-5) e pelo fomento do projeto JP (processo 2015/02527-1) do Profº Dr Igor Cesarino, no qual meu projeto de mestrado está inserido. RESUMOAs características físico-químicas da parede celular constituem um grande gargalo na obtenção dos açúcares fermentáveis a partir dos polissacarídeos de parede celular presentes na biomassa, fato conhecido como recalcitrância da biomassa vegetal. A utilização da biomassa na produção de biocombustíveis requer um melhor entendimento sobre os mecanismos que permeiam os processos de deposição de parede celular e metabolismo de lignina. Nesse contexto, a maior parte do conhecimento foi gerado em espécies eudicotiledôneas, havendo uma significativa lacuna para gramíneas, apesar do seu grande potencial para acúmulo de biomassa.Portanto, há uma necessidade de se estabelecer ferramentas-modelos que permitam elucidar características exclusivas da parede celular secundária de gramíneas C4, cujo c...

show abstract

In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption

Cited by 93 publications

References 28 publications

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Cultura de células em suspensão como ferramenta para estudos em parede celular secundária em gramíneas C4

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In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption

Cited by 93 publications

References 28 publications

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Cultura de células em suspensão como ferramenta para estudos em parede celular secundária em gramí­neas C4

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Cultura de células em suspensão como ferramenta para estudos em parede celular secundária em gramíneas C4