In vivo effects of ethanol on the rat myocardium: Evidence for a reversible, non-specific increase of sarcolemmal permeability

Polimeni, Philip I.; Otten, Maureen; Hoeschen, L.E.

doi:10.1016/0022-2828(83)90287-0

Cited by 27 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies indicate that (1) the effects of ethanol in amounts routinely ingested by man, i.e., those leading to clinically relevant ethanol plasma concentrations (0.1-0.15%, vol/vol), produce a negative inotropic effect that is predominantly due to decreased myofilament Ca2"-responsiveness (Schulman et al, 1989;Danziger et al, 1991). Higher concentrations (1-5%, vol/ vol) depress both the amplitude of the Ca2"-transient as well as alter myofilament Ca2+-responsiveness (Katz, 1982;Polimeni et al, 1983;Taraschi & Rubin 1985). Our results suggest that the negative inotropic effect of cocaethylene was due to both actions, in contrast to cocaine, which may explain its greater potency as a negative inotropic agent.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes

Qiu

Morgan

1993

British J Pharmacology

View full text Add to dashboard Cite

1 Isolated cardiac myocytes of the ferret were used to investigate the influence of cocaine and cocaethylene on the intracellular Ca2`transient indicated by the indo-l 405/480 nm ratio signal, and peak cell shortening.2 Both cocaine and cocaethylene produced significant decreases in peak intracellular Ca2`and peak cell shortening in a dose-dependent manner. Of interest, (1) the minimally effective dose of cocaethylene was ten fold lower (10-8 M versus 10-M) than that of cocaine; (2) the log EC, of cocaethylene was -5.99 ± 0.13 (1.0 x 10-6M), which was about ten fold lower than that of cocaine (-5.02 ± 0.11, 9.6 X 10-6 M); and (3) 1 x 10-4 M cocaethylene decreased the contraction amplitude by 71 ± 7%, while the same concentration of cocaine decreased the amplitude only by 55 ± 5%, indicating that cocaethylene is more potent than cocaine. 3 The negative inotropic effects of either cocaine or cocaethylene could be overcome by noradrenaline (5 gM) or calcium.4 In contrast to cocaine, cocaethylene shifted the peak [Ca2+]i-peak shortening relationship downward, indicating that cocaethylene decreased myofilament Ca2+-responsiveness. 5 These data indicate that both cocaine and cocaethylene act directly on cardiac myocytes to produce a negative inotropic effect that is due to decreased Ca2+ availability. In contrast to cocaine, cocaethylene produces more potent inhibition by an additional action to decrease myofilament Ca2+-responsiveness.

show abstract

Section: Discussionmentioning

confidence: 99%

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes

Qiu

Morgan

1993

British J Pharmacology

View full text Add to dashboard Cite

show abstract

The Cardiomyopathies

Hosenpud¹

1994

Congestive Heart Failure

View full text Add to dashboard Cite

Cardiovascular Effects of Ethanol

Frıedman¹

1992

Medical and Nutritional Complications of Alcoholism

View full text Add to dashboard Cite

In vivo effects of ethanol on the rat myocardium: Evidence for a reversible, non-specific increase of sarcolemmal permeability

Cited by 27 publications

References 38 publications

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes

The Cardiomyopathies

Cardiovascular Effects of Ethanol

Contact Info

Product

Resources

About

In vivo effects of ethanol on the rat myocardium: Evidence for a reversible, non-specific increase of sarcolemmal permeability

Cited by 27 publications

References 38 publications

Differential effects of cocaine and cocaethylene on intracellular Ca24+ and myocardial contraction in cardiac myocytes

Differential effects of cocaine and cocaethylene on intracellular Ca24+ and myocardial contraction in cardiac myocytes

The Cardiomyopathies

Cardiovascular Effects of Ethanol

Contact Info

Product

Resources

About

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes

Differential effects of cocaine and cocaethylene on intracellular Ca²⁴⁺ and myocardial contraction in cardiac myocytes