In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury

Erdaş, Meltem; Akyüz, Fahrettin; Can, Betül; Özkoç, Mete; Öz, Semih; Dönmez, Dilek Burukoğlu

doi:10.1007/s10863-021-09883-7

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…This CCl 3 ∗ radical interacts with reactive oxygen species (ROS), leading to the generation of another radical known as trichloromethyl peroxyl radical (OOCCl 3 ∗). The presence of the two radicals CCl 3 ∗ and OOCCl 3 ∗ contributes to an increase in oxidative stress, triggering various pathways including lipid peroxidation ( Erdaş et al, 2021 ), disruption of the glutathione pathway ( Bikheet et al, 2022 ) and the production of pro-inflammatory cytokines, specifically TNF-α ( Devi et al, 2021 ) and IL-6 ( Wali et al, 2021 ). These cumulative effects ultimately contribute to liver damage.…”

Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

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In this current study, we explored the preventive capacity of the aqueous extract of Orobanche foetida (OF), a root holoparasite, against CCl4 prompt hepatotoxicity in rats. LC-MS/MS profiling revealed the existence of 32 compounds belonging to organic acids, benzoic acid derivatives, and hydroxycinnamic acids along with their glycosides and derivatives as well as several flavonoids. In vitro, OF demonstrated substantial antioxidant potential at DPPH and ABTS assays. Results showed that the pretreatment with OF for 6 weeks at the doses (25 mg/kg bw) and (50 mg/kg bw) countered the CCl4-induced liver injury by restoring liver injuries indicators (ALT, AST, LDH, ALP, GGT and bilirubin), normalizing lipid profile (TC, TG, LDL-C, and HDL-C), as well as, impeding DNA fragmentation. Furthermore, OF blocked the hepatic oxidative stress spurred by CCl4 administration through boosting antioxidant enzymes (GSH, CAT, and SOD) responsible of diminishing lipid peroxidation. exhibited an anti-inflammatory effect by downregulating TNF-α and IL-6 levels. OF suppressive effect on proinflammatory cytokines is further exerted by its capacity to modulate the expression of the NF-κB gene. In silico investigation revealed that among the 32 identified compounds, vanillic acid glucoside and dihydroxybenzoic acid glucoside have strong and stable bindings with the active sites of three key inflammatory proteins (PARP-1, TNF-α, IL-6), which could highlight the antioxidant and anti-inflammatory capacity of. Overall, this research provides a preliminary pharmacological support for the medicinal applications of Orobanche foetida for addressing inflammatory and hepato-pathological conditions.

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Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

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“…The extract decreased ALT and AST enzymes increased by CCl 4. [101] Acute toxicity testing according to the oral administration method.…”

Section: Male Wistar Albino Ratsmentioning

confidence: 99%

A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts

Melo

Batista

Peñaloza

et al. 2023

Plants

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The genus Viscum comprises a large number of semi-parasitic shrubs popularly known as Mistletoe. The Viscum species grow in many countries of Europe, Africa and Asia with different popular uses in ornamentation, foods and medicine. Many studies about Viscum have been done over the last years focusing on biological activities and chemical composition of the aqueous extracts, mainly related to anthroposophical medicines. However, it is known that non-aqueous preparations, as alcoholic extracts, have demonstrated different biological activities that are species—and host tree—dependent. Considering the potential of these alcoholic extracts, a scoping review was conducted using data from three online databases: PubMed, Scopus and Embase. Inclusion criteria consisted of the in vitro, in vivo, ex vivo, clinical and chemical studies of alcoholic extracts from Viscum species. The present review summarized 124 original publications about fourteen Viscum species. Viscum album, Viscum articulatum and Viscum coloratum were the main studied species. Alcoholic extracts demonstrated hypotensive, anticancer, antimicrobial, analgesic and anti-inflammatory capabilities, among other biological activities. Flavonoids, phenolic acids and terpenoids represented 48%, 24% and 11% of the total identified compounds, respectively. This review contributes to the knowledge of alcoholic preparations of the Viscum species and points out the lack of clinical studies concerning these different extracts.

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“…由于钙超载及过量活性氧自由基产生等原因导致的炎症反应的加重 (2,3,4) ，其中巨噬细胞作为主要免疫细胞可通过多种途径参与 HIRI 进程 (5,6) 。作为临床常见并发症之一，HIRI 多见于感染、低血容量性休克、肝移植、部分肝切除 (7,8) 。HIRI 可能导致患者术后恢复缓慢、移植免疫排斥反应增加、移植物功能障碍，严重时可导致患者器官衰竭和死亡 (9,10) 。虽然目前临床已采取一定手段预防 HIRI，但迄今为止相关机制的研究和干预手段仍较为匮乏。近年来，肠道共生菌在参与调节肝脏功能及相关疾病进展的研究屡见不鲜，有研究表明一些共生菌可通过本身或其代谢产物调节肠道微环境：例如鼠李糖乳杆菌 R0011 (Lactobacillus rhamnosus R0011) 和嗜酸乳酸杆菌 R0052 (Lactobacillus acidophilus R0052)可通过降低肠道大肠杆菌丰度及细菌内毒素含量改善酒精性肝炎患者的肝损伤 (11) 。此外部分共生菌还可以通过调节免疫系统缓解肝损伤 (12) ，例如植物乳杆菌 C88(Lactobacillus plantarum C88)可以通过抑制 TLR2/NF-κB 信号通路，减少促炎因子释放从而减轻肝脏炎症反应及损伤 (13) ；长双歧杆菌 R1075(Bifidobacterium longum R0175)不仅可以抑制促炎因子的产生，还可以通过降低有害菌的相对丰度来改善肝脏损伤 (14) 。因此挖掘肠道共生菌与 HIRI 相关性对寻找 HIRI 新的治疗和干预方式具有十分重要的意义。本课题组通过不同抗生素联用筛选发现革兰氏阳性菌在 HIRI 进程中具有一定保护作用。同时结合本课题组前期研究工作，我们发现粪球菌 Coprococcus 的丰度变化与 HIRI 有一定相关性 (15) 。Coprococcus 目前已被报道与肝硬化及非酒精性脂肪肝等多种肝脏疾病相关 (16,17) 。作为粪球菌 Coprococcus 属的模式菌，有研究表明 Coprococcus catus (C. catus)丰度与抑郁症及子痫呈负相关 (18,19) 。此外 C. catus 还可以产生丁酸 (20) ，丁酸可以通过调控肠道菌群组成、抑制肝脏巨噬细胞激活及降低肝细胞过氧化来保护肝脏 (21,22) 要的角色，肠道菌群失衡和肠道屏障的损伤将增加细菌移位及肠道菌群代谢物变化，进而引发肝脏炎症和损伤 (25) 。研究表明一些共生菌不仅可以通过降低细菌内毒素的产生、提高宿主肠道的抗炎作用、还可以通过参与抗菌素的合成等多种途径减轻肝脏损伤 (26,27) 。因此，肠道菌群在肝病的研究中具有巨大的潜在临床意义和转化价值。目前 C. catus 作为肠道共生菌参与多种疾病进展已有报道 (19,20)…”

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The protective effect of <italic>Coprococcus catus</italic> on hepatic ischemia-reperfusion injury in mice

Yao¹,

Li²,

Chen³

2022

Sci. Sin.-Vitae

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Hepatic ischemia reperfusion injury (HIRI) is a common complication after shock or liver surgery. The gut microbiota plays an important role in liver injury, but the relationship between gut microbiota and HIRI has not been fully understood. In order to further explore the detail contribution of gut microbiota to HIRI, here we studied the potential effect of intestinal symbiotic bacteria (Coprococcus catus, C. catus) on HIRI progression in mice. We established mice HIRI model (70% liver blood flow was restricted for 90 min, followed by 6 h reperfusion) and mice were gavaged with narrow-spectrum antibiotics to deplete gut microbiota. Clodronate liposomes were employed to deplete macrophages in vivo. Our results showed that HIRI was exacerbated after the depletion of gram-positive bacteria, but this phenomenon did not occur in the depletion of gram-negative bacteria. In addition, the intestinal gram-positive commensal bacteria (C. catus) can improve HIRI in mice.Compared with C. catus culture supernatant, inactivated C. catus displayed a significant improvement of HIRI. Furthermore, C. catus still showed a certain tendency to protect HIRI in macrophage-cleared mice. In this study, we reported the beneficial effects of a new strain of intestinal gram-positive anaerobe-C. catus against HIRI in mice. C. catus may partially rely on macrophages to relieve inflammation and liver damage during HIRI.

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In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury

Cited by 8 publications

References 25 publications

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts

The protective effect of <italic>Coprococcus catus</italic> on hepatic ischemia-reperfusion injury in mice

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In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury

Cited by 8 publications

References 25 publications

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts

The protective effect of &lt;italic&gt;Coprococcus catus&lt;/italic&gt; on hepatic ischemia-reperfusion injury in mice

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The protective effect of <italic>Coprococcus catus</italic> on hepatic ischemia-reperfusion injury in mice