In Vivo Efficacy of a New Autologous Fibrin Sealant

Alston, Steven M.; Solen, Kenneth A.; Sukavaneshvar, Sivaprasad; Mohammad, Sameer

doi:10.1016/j.jss.2007.08.006

Cited by 29 publications

(22 citation statements)

References 18 publications

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“…described another cost effective method of autologus fibrin sealant from protamine precipitated fibrinogen concentrate. [50] De Somer et al . have demonstrated the mechanical and chemical characterstics of autologus surgical glue made by mixing ultra filtered plasma with gluteraldehyde.…”

Section: Large-scale Preparation Of Thrombin From Human Plasmamentioning

confidence: 99%

Fibrin glue in ophthalmology

Panda

Kumar

et al. 2009

Indian J Ophthalmol

176

143

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Suturing is a time consuming task in ophthalmology and suture induced irritation and redness are frequent problems. Postoperative wound infection and corneal graft rejection are examples of possible suture related complications. To prevent these complications, ophthalmic surgeons are switching to sutureless surgery. A number of recent developments have established tissue adhesives like cyanoacrylate glue and fibrin glue as attractive alternatives to sutures. A possible and promising new application for tissue adhesives is to provide a platform for tissue engineering. Currently, tissue glue is being used for conjunctival closure following pterygium and strabismus surgery, forniceal reconstruction surgery, amniotic membrane transplantation, lamellar corneal grafting, closure of corneal perforations and descematoceles, management of conjunctival wound leaks after trabeculectomy, lid surgery, adnexal surgery and as a hemostat to minimise bleeding. The purpose of this review is to discuss the currently available information on fibrin glue.

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Section: Large-scale Preparation Of Thrombin From Human Plasmamentioning

confidence: 99%

Fibrin glue in ophthalmology

Panda

Kumar

et al. 2009

Indian J Ophthalmol

176

143

View full text Add to dashboard Cite

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“…These findings suggest that fibrin is superior to collagen as a component of composite scaffolds for enhancing the biological performance of synthetic polymer scaffolds or as a sole material in various bone regenerative applications. Furthermore, fibrin can be prepared from autologous blood products, which highlights its importance in clinical applications (23,24). Because scaffolds for bone tissue regeneration require adequate mechanical strength and timely degradation properties, further studies on the modification of these properties due to fibrin must be performed.…”

Section: Resultsmentioning

confidence: 99%

Comparative evaluation of the biological properties of fibrin for bone regeneration

Oh¹,

Kim²,

Kim³

et al. 2014

BMB Reports

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Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effects of fibrin and collagen on the proliferation and differentiation of osteoblasts and protein adsorption. Compared to collagen, fibrin adsorbed approximately 6.7 times more serum fibronectin. Moreover, fibrin allowed the proliferation of larger MC3T3-E1 pre-osteoblasts, especially at a low cell density. Fibrin promoted osteoblast differentiation at higher levels than collagen, as confirmed by Runx2 expression and transcriptional activity, alkaline phosphatase activity, and calcium deposition. The results of the present study suggest that fibrin is superior to collagen in the support of bone regeneration. [BMB Reports 2014; 47(2): 110-114]

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“…First, the FG used in this study was derived from pig and thus heterologous in rabbits, which may have lead to possible reactions or infl ammation that would not be seen with autologous use. Some studies using an autologous fi brin sealant preparation [17][18][19] showed better results than commercial products in surgery. Second, slight microvillus protuberances on the surface of the cell membrane were more often observed in the control cells than in the cells cultured with FG ( Fig.…”

Section: Discussionmentioning

confidence: 99%