In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review

Sartini, Francesco; Menchini, Martina; Posarelli, Chiara; Casini, Giovanni; Figus, Michele

doi:10.3390/app11020724

Cited by 9 publications

(4 citation statements)

References 81 publications

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“…Moreover, alternative delivery systems for IOP lowering medications, which do not require the daily eye drops administration, will permit the reduction of the cumulative burden of the medical therapy on the ocular surface. Based on this need, slow-release devices designed to be introduced in the lacrimal punctum, or into the fornix, the subconjunctival space, or inside the anterior chamber are being developed (Figus et al 2020;Sartini et al 2021).…”

Section: Major Gaps In Knowledge and Possible Solutionsmentioning

confidence: 99%

Preparing the ocular surface for glaucoma filtration surgery: an unmet clinical need

Agnifili

Sacchi

Figus

et al. 2022

Acta Ophthalmologica

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The mutual relationship among medical therapy, ocular surface (OS) and filtration surgery (FS) represents one of the most crucial issues in glaucoma management. As the long-term use of intraocular pressure-lowering medications significantly affect the OS health, patients with an uncontrolled disease frequently undergo glaucoma surgery in less-than-ideal conditions. As we known, OS changes strongly affect the post-operative bleb filtration capability. Therefore, improving the OS conditions before proceeding with FS is needed. Currently, given the rapid diffusion of new surgical procedures, this need is even more perceived. Nevertheless, despite surgeons retain the OS preparation of primary importance, and recognize the OS disease (OSD) as the only modifiable risk factor for filtration failure, there is no agreement on which strategies should be preferred to prepare patients. This is largely due to the lack of validated guidelines, which forces clinicians to adopt personal approaches based on evidence derived from low-quality studies. In this review, we provided an overview of risk factors involved in the FS failure, with particular attention to those depending on OS changes, and how OSD negatively affects the aqueous humor resorption after surgery. Moreover, we reported the most exploited measures to mitigate the OSD before surgery, the possible reasons underlying the absence of shared approaches, and the upcoming area of intervention to preserve the OS health during glaucoma management. Finally, based on the current evidence, we proposed a pre-operative outline reporting the main risk factors that should be considered before surgery, and the therapeutical options available to improve the OS.

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Section: Major Gaps In Knowledge and Possible Solutionsmentioning

confidence: 99%

Preparing the ocular surface for glaucoma filtration surgery: an unmet clinical need

Agnifili

Sacchi

Figus

et al. 2022

Acta Ophthalmologica

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“…The use of polymer-based self-assembled drug delivery systems allows for the effective and long-term delivery of one or more drugs to treat glaucoma [31]. Herein we focus on polymer-based self-assembled drug delivery systems, especially non-surgical and nonimplanted systems positioned on or near the ocular surface, including Eye drops [32,33], Hydrogels [34,35], and Contact lenses [36,37], all incorporating polymers. These drugencapsulating systems function as effective drug delivery mechanisms, ensuring sustained drug release.…”

Section: Polymer-based Delivery Systems For Glaucoma Treatmentmentioning

confidence: 99%

Polymer-Based Self-Assembled Drug Delivery Systems for Glaucoma Treatment: Design Strategies and Recent Advances

Sun,

Wang,

Feng

et al. 2023

Polymers

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Glaucoma has become the world’s leading cause of irreversible blindness, and one of its main characteristics is high intraocular pressure. Currently, the non-surgical drug treatment scheme to reduce intraocular pressure is a priority method for glaucoma treatment. However, the complex and special structure of the eye poses significant challenges to the treatment effect and safety adherence of this drug treatment approach. To address these challenges, the application of polymer-based self-assembled drug delivery systems in glaucoma treatment has emerged. This review focuses on the utilization of polymer-based self-assembled structures or materials as important functional and intelligent carriers for drug delivery in glaucoma treatment. Various drug delivery systems, such as eye drops, hydrogels, and contact lenses, are discussed. Additionally, the review primarily summarizes the design strategies and methods used to enhance the treatment effect and safety compliance of these polymer-based drug delivery systems. Finally, the discussion delves into the new challenges and prospects of employing polymer-based self-assembled drug delivery systems for the treatment of glaucoma.

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“…[35] Functional nanoparticles with unique properties, such as no/low cytotoxicity, excellent physical/chemical features, and drug-delivery ability, have also been employed to improve/integrate some SCL properties. [51,62,[88][89][90] For example, it has been reported that the nanoparticles were incorporated into CL polymers and gelling systems to enhance mechanical strength and elasticity of CLs. [34] For example, organic dyeencapsulated silica nanoparticles were applied with PHEMA or PDMS to obtain precise biosensing capability, with the detection sensitivity of 0.5-5 mM of blood glucose.…”

Section: Encapsulationmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review

Cited by 9 publications

References 81 publications

Preparing the ocular surface for glaucoma filtration surgery: an unmet clinical need

Preparing the ocular surface for glaucoma filtration surgery: an unmet clinical need

Polymer-Based Self-Assembled Drug Delivery Systems for Glaucoma Treatment: Design Strategies and Recent Advances

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

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