In Vivo Electrochemical Biosensors: Recent Advances in Molecular Design, Electrode Materials, and Electrochemical Devices

Wang, Shidi; Liu, Yuandong; Zhu, Anwei; Tian, Yang

doi:10.1021/acs.analchem.2c04541

Cited by 54 publications

(22 citation statements)

References 175 publications

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“…Incorporating the natural bioselectivity of the biological component, electrochemical biosensors combine the sensitivity of electroanalytical methods with the analytical precision of the chemical component. Once the analyte has been recognized by the biological component of the sensor, a catalytic or binding event will follow, resulting in an electrical signal that is measured by a transducer and will be proportionate to the analyte concentration [ 108 , 109 , 110 , 111 , 112 , 113 ]. Electrochemical biosensors have been widely used in numerous industries, including clinical diagnostics, environmental monitoring, food safety analysis, etc., because of their ease of use, low cost, exceptional stability, and sensitive response [ 6 , 114 ].…”

Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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This review highlights the recent advancements in the field of nanozymes and their applications in the development of point-of-care biosensors. The use of nanozymes as enzyme-mimicking components in biosensing systems has led to improved performance and miniaturization of these sensors. The unique properties of nanozymes, such as high stability, robustness, and surface tunability, make them an attractive alternative to traditional enzymes in biosensing applications. Researchers have explored a wide range of nanomaterials, including metals, metal oxides, and metal–organic frameworks, for the development of nanozyme-based biosensors. Different sensing strategies, such as colorimetric, fluorescent, electrochemical and SERS, have been implemented using nanozymes as signal-producing components. Despite the numerous advantages, there are also challenges associated with nanozyme-based biosensors, including stability and specificity, which need to be addressed for their wider applications. The future of nanozyme-based biosensors looks promising, with the potential to bring a paradigm shift in biomolecular sensing. The development of highly specific, multi-enzyme mimicking nanozymes could lead to the creation of highly sensitive and low-biofouling biosensors. Integration of nanozymes into point-of-care diagnostics promises to revolutionize healthcare by improving patient outcomes and reducing costs while enhancing the accuracy and sensitivity of diagnostic tools.

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Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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“…However, most of these techniques are expensive and time-consuming, and require skilled manpower, tedious sample pretreatment, and huge instrumentation setup [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among them, the electrochemical biosensor is the most preferred technology due to its robustness, simplicity, rapidity, portability, cost-effectiveness, ease of handling, high sensitivity, and selectivity toward target analytes, in addition to reliable and reproducible responses [ 24 , 25 , 26 , 27 , 28 ]. In general, electrochemical sensing was performed in a three-electrode cell system composed of a modified working electrode (WE), reference electrode (RE), and counter electrode (CE).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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“…First, it is hard to identify various electrochemical signals selectively through electrochemical redox reactions. Although identification elements such as enzymes and aptamers were developed to improve the selectivity of in vivo detection, the number of natural enzyme and aptamer species was still limited, which inhibited further exploration of a wider range of chemical signals . Additionally, the identification process of these methods were usually irreversible, which made it difficult to continuously monitor the dynamics of the substance. , Second, the interfacial properties between the molecule and the electrode affected the stability of the electrode.…”

Section: Introductionmentioning

confidence: 99%

Implantable Electrochemical Sensors for Brain Research

Liu

Zhou

et al. 2023

JACS Au

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Implantable electrochemical sensors provide reliable tools for in vivo brain research. Recent advances in electrode surface design and high-precision fabrication of devices led to significant developments in selectivity, reversibility, quantitative detection, stability, and compatibility of other methods, which enabled electrochemical sensors to provide molecular-scale research tools for dissecting the mechanisms of the brain. In this Perspective, we summarize the contribution of these advances to brain research and provide an outlook on the development of the next generation of electrochemical sensors for the brain.

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In Vivo Electrochemical Biosensors: Recent Advances in Molecular Design, Electrode Materials, and Electrochemical Devices

Cited by 54 publications

References 175 publications

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Implantable Electrochemical Sensors for Brain Research

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