In vivo electrochemical detection of 5-hydroxyindole within the trigeminal nucleus caudalis of freely moving rats: the effect of morphine

Rivot, J.P.; Pointis, D.; Besson, Jean‐Marie

doi:10.1016/0006-8993(88)90400-3

Cited by 21 publications

(5 citation statements)

References 45 publications

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“…In the present study, acute systemic morphine administration did not induce significant changes in extracellular 5‐HT levels in the LS. In this regard, it has been reported that anesthetics including choral hydrate used in this study eliminate morphine effects on extracellular 5‐HT levels in different brain regions (Rivot et al, 1988; Tao and Auerbach, 1994). Further studies in awake rats thus are needed to determine whether LS 5‐HT is affected by morphine.…”

Section: Discussionmentioning

confidence: 75%

Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area

2005

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We studied the effect of an acute systemic administration of morphine and of a local intra-ventral tegmental area (VTA) infusion of the same drug on extracellular levels of dopamine (DA) in the lateral septum (LS) by in vivo microdialysis in anesthetized rats. The extracellular levels of 5-hydroxytryptamine (5-HT) were also measured in all dialysate samples. The acute systemic administration of morphine dose-dependently increased extracellular levels of DA but not of 5-HT in the LS, in the absence or presence of fluoxetine. This morphine effect was antagonized by the previous administration of naloxone, a specific opioid antagonist. The local infusion of morphine in the VTA also induced a significant increase of the extracellular levels of DA in the LS, concomitantly with a decrease of gamma-aminobutyric acid (GABA) extracellular levels in the VTA itself. Intriguingly, the LS extracellular levels of DA returned to basal values before the VTA GABA extracellular levels recovered. Our results show for the first time that an acute administration of morphine increases DA extracellular levels in the LS. The results also suggest that DA cells in the VTA and innervating the LS are under an inhibitory GABAergic tone sensitive to morphine. Taken together, our neurochemical data and previous studies involving LS DA in stress-related behavior support the hypothesis that DA in the LS plays a significant role in addictive behavior. The participation of LS DA and 5-HT systems in stress-induced relapse to drug seeking should be studied further.

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Section: Discussionmentioning

confidence: 75%

Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area

2005

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“…The 5-HIAA data are in good agreement with other reports that morphine enhances 5-HT turnover in the brain and spinal cord . Using in vivo voltametry, Besson and coworkers found that 5-HIAA levels in the rat medullary dorsal horn and nucleus raphe magnus were increased after morphine (Rivot et al, 1988;Puig et al ., 1991) . Morphine also enhanced 5-HT synthesis (Garcia-Sevilla et al ., 1980) and tryptophan hydroxylase activity (Boadle-Biber et al ., 1987) .…”

Section: Discussionmentioning

confidence: 99%

Increased Extracellular Serotonin in Rat Brain After Systemic or Intraraphe Administration of Morphine

Tao

Auerbach

1994

Journal of Neurochemistry

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The effect of morphine on serotonin (5‐HT) and 5‐hydroxyindoleacetic acid (5‐HIAA) in the CNS of unanesthetized rats was investigated by microdialysis. Morphine was administered either subcutaneously, by local perfusion into the diencephalon, or by intraraphe microinjection. Systemic administration of morphine resulted in a significant increase in both extracellular 5‐HT and 5‐HIAA in the diencephalon. The effect of morphine on 5‐HT was dose dependent during local perfusion of the diencephalon with inhibitors of uptake or monoamine oxidase. Systemic morphine also produced significant increases in extracellular 5‐HT in the striatum and hippocampus during uptake inhibition. The site of opioid effects on 5‐HT was tested by locally perfusing morphine into the diencephalon. This had no effect on 5‐HT or 5‐HIAA. In contrast, intraraphe injection of morphine caused a dose‐dependent increase in extracellular 5‐HT and 5‐HIAA in the diencephalon. These results suggest that systemic morphine induces an increase in 5‐HT release in widespread areas of the forebrain. This appears to be due to an effect on 5‐HT cell bodies and not on 5‐HT nerve endings in projection sites.

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“…For instance, either systemic or local (intraventricular or direct injection into the periaqueductal gray) administration of morphine evoked the release of 5‐HT from spinal cord terminals. 2,3 A significant increase in tissue levels of 5‐HT was observed in cat spinal dorsal horns after electrical stimulation of the dorsal column. 4 A role for 5‐HT in the antinociceptive effect of nonnarcotic analgesics has also been suggested.…”

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confidence: 97%

Effect of Chronic Analgesic Exposure on the Central Serotonin System: A Possible Mechanism of Analgesic Abuse Headache

Srikiatkhachorn¹,

Tarasub²,

Govitrapong³

2000

Headache

106

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In vivo electrochemical detection of 5-hydroxyindole within the trigeminal nucleus caudalis of freely moving rats: the effect of morphine

Cited by 21 publications

References 45 publications

Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area

Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area

Increased Extracellular Serotonin in Rat Brain After Systemic or Intraraphe Administration of Morphine

Effect of Chronic Analgesic Exposure on the Central Serotonin System: A Possible Mechanism of Analgesic Abuse Headache

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