1986
DOI: 10.1016/0014-2999(86)90094-4
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In vivo ‘enkephalinase’ inhibition by acetorphan in human plasma and CSF

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Cited by 45 publications
(28 citation statements)
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“…However, if the SP aerosol is given in sufficiently high concentrations (about 1 mM), it induces airway narrowing in the absence of NEP inhibition (Lotvall et al, 1989). The present and earlier (Dusser et al, 1988) (Johnson et al, 1985) and NEP in circulating blood (Spillantini et al, 1986 the observation that aerosolisation of 3 mm acetorphan, both in SP-and in ACh-challenged animals, induced a temporary increase in RL that was significantly larger than that seen after treatment with vehicle. This indicates that aerosolisation of vehicle may induce a slight tachykinin release, the effect of which is then potentiated by acetorphan, but there is no direct evidence to support this hypothesis.…”
Section: Discussionsupporting
confidence: 64%
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“…However, if the SP aerosol is given in sufficiently high concentrations (about 1 mM), it induces airway narrowing in the absence of NEP inhibition (Lotvall et al, 1989). The present and earlier (Dusser et al, 1988) (Johnson et al, 1985) and NEP in circulating blood (Spillantini et al, 1986 the observation that aerosolisation of 3 mm acetorphan, both in SP-and in ACh-challenged animals, induced a temporary increase in RL that was significantly larger than that seen after treatment with vehicle. This indicates that aerosolisation of vehicle may induce a slight tachykinin release, the effect of which is then potentiated by acetorphan, but there is no direct evidence to support this hypothesis.…”
Section: Discussionsupporting
confidence: 64%
“…Such hydrolysation has been demonstrated to take place in mouse brain membranes (Lecomte et al, 1986) and in plasma (Spillantini et al, 1986). Our data show that acetorphan also must be hydrolysed locally in the airways, presumably in the airway epithelium.…”
Section: Discussionsupporting
confidence: 59%
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“…Control animals (n = 10) were subjected to a sham operation. After 9 days the animals were placed in metabolic cages and urine samples were collected over 24 h and analysed for NEP activity (Spillantini et al 1986). Six animals from each group were then anaesthetized with Inactin (REI; 120 mg kg-I ; I.P.)…”
Section: Department Of Physiology Medical School Birmingham Eis 2ttmentioning
confidence: 99%