In vivo evaluation and characterization of a bio-absorbable drug-coated stent fabricated using a 3D-printing system

Park, Su A; Lee, Sang Jin; Lim, Kyung Seob; Bae, In Ho; Lee, Jun Hee; Kim, Wan Doo; Jeong, Myung Ho; Park, Jun-Kyu

doi:10.1016/j.matlet.2014.11.119

Cited by 113 publications

(66 citation statements)

References 9 publications

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“…AM refers to processes used to create a 3D object in which layers of material are formed under computer control. The use of this technology for stent manufacture is recent [57][58][59][60][61][62][63][64] and could be a really interesting method to produce stent. Mainly, there are four different AM technologies in the stent field.…”

Section: Promising Stent Manufacturing Processesmentioning

confidence: 99%

Stent’s Manufacturing Field: Past, Present, and Future Prospects

Guerra¹,

Ciurana²

2019

Angiography

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From the introduction of stents, nobody was able to predict the advances that will occur in stent technology over the upcoming decades. Since their appearances, it became evident that this device had significant limitations, such as vessel occlusion and/or restenosis. Despite that, this medical device is the best clinical solution for cardiovascular vessel occlusions. Stents require a deep analysis, in terms of thrombogenicity, manufacturing process, geometrical aspects, and mechanical performance, among many other characteristics. The surface quality obtained in their manufacture process is crucial to blood compatibility, prevents the activation process of thrombosis, and improves the healing efficiency. The forecast stent market makes necessary continuous studies on this field, which help to solve the medical and engineering problems of this device, which are in constant development. Stents have been the center of many research lines over the last decades. The present chapter aims to summarize the state of the art of this medical device in the last years in the fields of design, manufacturing, and materials.

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Section: Promising Stent Manufacturing Processesmentioning

confidence: 99%

Stent’s Manufacturing Field: Past, Present, and Future Prospects

Guerra¹,

Ciurana²

2019

Angiography

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“…Liu Qing [3] applied for a method and a device for preparing a 3D porous tubular stent, and prepared a 3D porous tubular stent by a 3D printing method, but the stent structure is relatively single. Park [4] used a 3D printing technique to prepare tubular PCL scaffolds to study the effects of drug coating and non-drug coated PCL stent implantation and stent degradation in vitro. The surface morphology and mechanical properties of the stent mainly depend on the molding process of the stent.…”

Section: Introductionmentioning

confidence: 99%

3D Printing and Characterization of the Biodegradable Vascular Stent

Xu¹,

Li²,

Shi³

et al. 2018

IJCEE

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Vascular stent is an important kind of medical device for the treatment of the vessel occlusion. In this work, we designed and fabricated a kind of biodegradable vascular stent. The dynamics of expanding, compressing and bending process for the single "sine", "60 degrees sine" and "U" type stent unites were analyzed with Finite Element Method (FEA) respectively, and furthermore, the expanding characters of polylactic acid (PLA) stent models with length of 4mm, 6mm, and 8mm were simulated. The "sine" type bracket had a better dynamic property and thus was more suitable for medical stent implantation in terms of mechanical properties. Then, the stent errors including the movement, the nozzle deposition and the shrinkage of the material were analyzed which provided experimental basis for the designing of the stent. The brachial artery stent implantation on pig experimental animals was carried out using the 3D printed PLA vascular stents. Results showed that the 3D printed vascular could be transported into the stenosis place and expand the vessel after pulling out of the balloon. The blood supply function was normal and the biodegradation could be observed after 30 days. This paper provided a novel method for clinical transformation of biodegradable vascular stents.

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“…Laser machining can lead to thermal and chemical defects at the machining site [10]. Several groups have reported the fabrication of coronary stents using 3D printing methods [11,12]. Park et al [11] fabricated a bioresorbable drug-coated stent via extrusion techniques on the surface of a cylindrical template followed by the spray coating of the immunosuppressive drug sirolimus.…”

mentioning

confidence: 99%

“…Several groups have reported the fabrication of coronary stents using 3D printing methods [11,12]. Park et al [11] fabricated a bioresorbable drug-coated stent via extrusion techniques on the surface of a cylindrical template followed by the spray coating of the immunosuppressive drug sirolimus. The release kinetics of sirolimus from the stent showed a sustained release profile in porcine preclinical studies [11].…”

mentioning

confidence: 99%

“…Park et al [11] fabricated a bioresorbable drug-coated stent via extrusion techniques on the surface of a cylindrical template followed by the spray coating of the immunosuppressive drug sirolimus. The release kinetics of sirolimus from the stent showed a sustained release profile in porcine preclinical studies [11]. However, the fabricated stent geometry has to be strictly conformal to the cylindrical template used and thus severely limits the freedom in design and fabrication of customized stent geometries.…”

mentioning

confidence: 99%

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