In vivo evaluation and comparison of developmental toxicity and teratogenicity of perfluoroalkyl compounds using Xenopus embryos

Kim, Miran; Son, Jungeun; Park, Mi Seon; Ji, Yurim; Chae, Soomin; Jun, Chang‐Duk; Bae, Jong‐Sup; Kwon, Tae Chan; Choo, Yun-Sik; Yoon, Ho-Sung; Yoon, Duhak; Ryoo, Jaewoong; Kim, Sang-Hyun; Park, Mae-Ja; Lee, Hyun‐Shik

doi:10.1016/j.chemosphere.2013.06.053

Cited by 28 publications

(19 citation statements)

References 51 publications

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“…In particular, xPTB was used as a liver-specific marker and the protein encoded by this gene complexes with the LDL receptor to mediate hepatic LDL removal by endocytosis (35,36). Consistent with other reports, the xPTB mRNA levels were considerably modulated following exposure to either PFHxA or PFHpA (16). This specific reduction in the xPTB mRNA level may cause increased LDL accumulation in the liver, which can in turn lead to chronic cardiac disease, such as atherosclerosis and myocardial infarction (37).…”

Section: Discussionsupporting

confidence: 76%

“…3A and C). Previous findings have also shown reduced xPTB expression following exposure to various PFCs (16,25,26). Furthermore, the heart-specific marker, NKX2.5, was used to examine the effects of PFCs on the heart.…”

Section: Pfc Exposure Alters Tissue-specific Mrna Expression In Vivomentioning

confidence: 98%

“…Overexposure to these anthropogenic chemicals causes severe fetal abnormalities in amphibians and affects human development (12,16). The toxicity of PFCs is commonly determined by their carbon chain length and by the functional group.…”

Section: Introductionmentioning

confidence: 99%

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Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

Kim

Park

Son

et al. 2015

International Journal of Molecular Medicine

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Section: Discussionsupporting

confidence: 76%

Section: Pfc Exposure Alters Tissue-specific Mrna Expression In Vivomentioning

confidence: 98%

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Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

Kim

Park

Son

et al. 2015

International Journal of Molecular Medicine

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“…In addition, PFASs have also been detected in plankton, fish, mammals, and even humans (Lam et al, 2014;Zhou et al, 2014). Studies showed that some PFASs have toxicological risks to organisms, such as developmental toxicity and endocrine disrupting effects (Kim et al, 2013;Wang et al, 2011a). It is widely recognized that PFASs are persistent in the environment (Conder et al, 2008), and can be accumulated in many kinds of organisms (Martin et al, 2003;Yeung et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Bioconcentration of perfluoroalkyl substances by Chironomus plumosus larvae in water with different types of dissolved organic matters

Wen

Xia

Chen

et al. 2016

Environmental Pollution

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The effects of four types of dissolved organic matters (DOM) on the bioconcentration of perfluoroalkyl substances (PFASs) in Chironomus plumosus larvae have been studied. The PFASs included perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), and perfluorododecanoic acid (PFDoA). The DOM included humic acid (HA), fulvic acid (FA), tannic acid (TA), and a protein, peptone (PEP), and their concentrations ranged from 0 to 50 mg L(-1). The results showed that, upon bioconcentration equilibrium, the body burdens of longer perfluoroalkyl chain PFASs (PFOS, PFDA, PFUnA and PFDoA) decreased with PEP and HA concentrations while increased with FA and TA concentrations. When FA and TA concentrations increased from 0 to 50 mg L(-1), body burdens of these PFASs increased by 7.5%-148.8% and 5.7%-37.1%, respectively. However, the DOM had no significant impact on the body burdens of shorter perfluoroalkyl chain PFASs (PFOA and PFNA). All of the four types of DOM lowered not only the uptake rate constants (ku) of PFASs due to the decrease of freely dissolved PFAS concentrations, but also the elimination rate constants (ke) due to the inhibition effect of DOM on the PFAS elimination from the larvae. The reduction in the two constants varied with both DOM and PFAS types. In the presence of PEP and HA with larger molecular weights, the ku values decreased more than ke, leading to the decreased body burdens of longer perfluoroalkyl chain PFASs. As for FA and TA with smaller molecular weights, the ke values decreased more than ku, resulting in increased body burdens of longer perfluoroalkyl chain PFASs. This study suggests that the effects of DOM on PFAS bioconcentration depend not only on the concentration but also on the molecule weight of DOM, which should be considered in the bioavailability assessment of PFASs.

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“…Numerous animal models are used to study developmental biology, chief among them the fruit fly (Drosophila melanogaster), the nematode (Caenorhabditis elegans), the chicken (Gallus gallus), the mouse (Mus musculus), the frog (Xenopus laevis), and the zebrafish (Danio rerio) (Jenner and Wills, 2007). These model organisms have all been successfully utilized to study aspects of toxicant response during development (Lewandowski et al, 2003;Boyd et al, 2009;Ruden et al, 2009;Jiang et al, 2012;Bailey et al, 2013;Kim et al, 2013). However, biologic differences between animals and humans can pose a problem in extrapolating the toxicologic response mechanisms identified in these model organisms to humans.…”

Section: Introductionmentioning

confidence: 99%

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

Spade

McDonnell

Heger

et al. 2014

Birth Defects Research Pt B

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Many diseases that manifest throughout the lifetime are influenced by factors affecting fetal development. Fetal exposure to xenobiotics, in particular, may influence the development of adult diseases. Established animal models provide systems for characterizing both developmental biology and developmental toxicology. However, animal model systems do not allow researchers to assess the mechanistic effects of toxicants on developing human tissue. Human fetal tissue xenotransplantation models have recently been implemented to provide human-relevant mechanistic data on the many tissue-level functions that may be affected by fetal exposure to toxicants. This review describes the development of human fetal tissue xenotransplant models for testis, prostate, lung, liver, and adipose tissue, aimed at studying the effects of xenobiotics on tissue development, including implications for testicular dysgenesis, prostate disease, lung disease, and metabolic syndrome. The mechanistic data obtained from these models can complement data from epidemiology, traditional animal models, and in vitro studies to quantify the risks of toxicant exposures during human development.

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In vivo evaluation and comparison of developmental toxicity and teratogenicity of perfluoroalkyl compounds using Xenopus embryos

Cited by 28 publications

References 51 publications

Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK

Bioconcentration of perfluoroalkyl substances by Chironomus plumosus larvae in water with different types of dissolved organic matters

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

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