In vivo evaluation of a new hydrophobic acrylic intraocular lens in the rabbit model

Werner, Liliana; Ellis, Nathan; Heczko, Joshua; Ong, Marcia; Jain, Rakhi; Wolfe, Patricia; Peterson, Telyn; Jiang, Bill; Mamalis, Nick

doi:10.1016/j.jcrs.2018.07.040

Cited by 10 publications

(10 citation statements)

References 19 publications

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“…The authors concluded that the Clareon is likely to perform as well as, and possibly better than, AcrySof in terms of Nd:YAG capsulotomy rates. Furthermore, an in vivo rabbit study in fifteen New Zealand white rabbits with a follow up of 1 month did not detect a difference in PCO and anterior capsule opacification, as observed during clinical and pathological evaluation between the Clareon and the AcrySof IOL [19]. Our human ex vivo data in the capsular bag model shows a comparable result.…”

Section: Discussionsupporting

confidence: 60%

Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model

et al. 2020

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Background: Posterior capsule opacification (PCO) after cataract surgery is influenced by intraocular lens (IOL) design and material. The following is an ex vivo comparison of PCO between the Clareon vs. the AcrySof IOL in human capsular bags. Methods: Twenty cadaver capsular bags from 10 human donors were used, with the novel hydrophobic IOL (Clareon, CNA0T0) being implanted in one eye and the other eye of the same donor receiving the AcrySof IOL (SN60WF) following phacoemulsification cataract surgery. Five capsular bags of 3 donors served as controls without IOL. Cellular growth of lens epithelial cells was photo-documented daily. The primary endpoint was the time until full coverage of the posterior capsule by cells. Furthermore, immunofluorescence staining of capsular bags for the fibrotic markers f-actin, fibronectin, alpha smooth muscle actin, and collagen type 1 were performed. Results: The new Clareon IOL did not show any disadvantages in terms of days until full cell coverage of the posterior capsule in comparison to the AcrySof (p > 0.99). Both, the Clareon (p = 0.01, 14.8 days) and the AcrySof IOL (p = 0.005, 15.7 days) showed a slower PCO development in comparison to the control (8.6 days). The fibrotic markers f-actin, fibronectin, alpha smooth muscle actin, and collagen type 1 were equally distributed between the two IOLs and differed from the control. Conclusions: A comparable performance has been found in the ex vivo formation of PCO between the two IOLs. Long-term clinical studies are necessary to reach final conclusions.

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Section: Discussionsupporting

confidence: 60%

Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model

et al. 2020

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“…12 The IOL is made of a hydrophilic (2-hydroxymethyl methacrylate) and a hydrophobic polymer component (phenylethyl acrylate), with an ultraviolet light-filtering and a blue light-filtering chromophore incorporated into the material. [13][14][15][16] The Clareon IOL has a water content of 1.5% at 35°C, a refractive index of 1.55, and a glass transition temperature of 9.1°C. [13][14][15][16] The IOL is preloaded in an automated preloaded delivery system (AutonoMe CNA0T0) and available in powers of +6.00 to +30.00 D.…”

Section: Intraocular Lensesmentioning

confidence: 99%

“…[13][14][15][16] The Clareon IOL has a water content of 1.5% at 35°C, a refractive index of 1.55, and a glass transition temperature of 9.1°C. [13][14][15][16] The IOL is preloaded in an automated preloaded delivery system (AutonoMe CNA0T0) and available in powers of +6.00 to +30.00 D.…”

Section: Intraocular Lensesmentioning

confidence: 99%

Anterior chamber depth variability between 2 hydrophobic acrylic 1-piece intraocular lenses: randomized trial

Ullrich

Ruiß²,

Hienert³

et al. 2021

J Cataract Refract Surg

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“…Both AcrySof® IQ and Clareon® lenses feature square edge designs that aim to prevent PCO by inhibiting epithelial cell migration. Studies that have compared the incidence of PCO following implantation of SN60WF and Clareon® IOLs in rabbit and explanted capsular bags from human cadavers reported no difference in PCO incidence or progression rates [13,14]. However, a large-scale meta-analysis reported that incidence of PCO requiring Nd: YAG capsulotomy within the first year of surgery in humans was higher in eyes that received SN60WF lenses compared to Clareon® lenses (1.44% versus 0.62%, respectively) [15].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Visual Outcomes and Patient Satisfaction Following Cataract Surgery with Two Monofocal Intraocular Lenses: Clareon® vs AcrySof® IQ Monofocal

Agarwal¹,

Thornell²

2021

TOOPHTJ

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Aim: This study aimed to compare the performance of two monofocal Intraocular Lenses (IOL) platforms. Background: The Clareon® Intraocular Lens (IOL) is a relatively new monofocal lens platform designed to improve postoperative results compared to other monofocal platforms. Objective: This study aimed to assess and compare the visual and refractive outcomes, and incidence of YAG capsulotomy of the Clareon® IOL and a standard non-preloaded AcrySof® monofocal IOL following contralateral implantation in patients undergoing cataract surgery. Methods: A total of 20 patients (40 eyes; 12 female, average age 72.8±6.4 years) who had undergone contralateral implantation of an AcrySof® IQ monofocal lens (SN60WF or SN6AT; Alcon; Texas, USA) and a Clareon®monofocal lens (CNAOT0; Alcon; Texas, USA) were selected. Uncorrected Distance Visual Acuity (UDVA), Contrast Sensitivity (CS), kinetic perimetry, and refraction were measured 1 month following the second surgery and subjective vision was measured 6 months following the second surgery using a quality-of-life questionnaire. Results: There was no difference in postoperative UDVA (P=0.94), CS (P>0.05), or refraction (P=0.64) between eyes that received the Clareon® and AcrySof® IQ lenses. Clareon® eyes had a higher incidence of glare/haloes and positive dysphotopsia while AcrySof® IQ eyes had a higher incidence of negative dysphotopsia. Patient satisfaction was similar between the groups (P=0.86), although 25% of patients reported more clarity in the eye that received the Clareon® lens. The incidence of posterior capsular opacification was low for both groups. Conclusion: Clareon® and AcrySof® IQ lenses perform similarly, providing good refractive, visual, and subjective outcomes. Clareon® is available as a preloaded lens option and may reduce PCO and the need for Nd: YAG capsulotomy.

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In vivo evaluation of a new hydrophobic acrylic intraocular lens in the rabbit model

Abstract: The new IOL showed biocompatibility and stability comparable to the control IOL.

Cited by 10 publications

References 19 publications

Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model

Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model

Anterior chamber depth variability between 2 hydrophobic acrylic 1-piece intraocular lenses: randomized trial

Comparison of Visual Outcomes and Patient Satisfaction Following Cataract Surgery with Two Monofocal Intraocular Lenses: Clareon® vs AcrySof® IQ Monofocal

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