In-Vivo Evaluation of a Novel Bipolar Radiofrequency Device for Interstitial Thermotherapy of Liver Tumors During Normal and Interrupted Hepatic Perfusion

Ritz, J.‐P.; Lehmann, Kai S.; Isbert, C.; Reißfelder, Christoph; Albrecht, Thomas; Stein, Thomas; Buhr, H. J.

doi:10.1016/j.jss.2005.09.028

Cited by 36 publications

(15 citation statements)

References 47 publications

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“…A bipolar radiofrequency system was used for ablation. Thermal energy was delivered through an applicator with a diameter of 1.8 mm (15F), a shaft length of 150 mm, and an active tip length of 30 mm (CelonProSurge 150-T30, Celon AG Medical Instruments, Teltow, Germany) [10]. An internal liquid circulation of the applicator using saline solution at room temperature was set to 30 ml/min.…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

“…Images were transferred to a software tool for the analysis of RF lesion analysis (RF measurement tool, Fraunhofer MEVIS, Bremen, Germany). The lesion border was identified by the macroscopically detectable color change of the coagulated liver tissue [10]. The lesion border and applicator position were marked manually with the software.…”

Section: Planimetry and Analysismentioning

confidence: 99%

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Ex situ quantification of the cooling effect of liver vessels on radiofrequency ablation

Lehmann

Ritz

Valdeig

et al. 2009

Langenbecks Arch Surg

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Section: Radiofrequency Ablationmentioning

confidence: 99%

Section: Planimetry and Analysismentioning

confidence: 99%

Ex situ quantification of the cooling effect of liver vessels on radiofrequency ablation

Lehmann

Ritz

Valdeig

et al. 2009

Langenbecks Arch Surg

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“…A bipolar RFA needle of 3 mm diameter [16] was re-designed and made in-house with a reduced 25-mm active (conducting) bipolar applicator, including a 5-mm insulator at the center to separate the two electrodes. This simplified bipolar needle (without internal cooling) was also used to compare results between simulated and experimental ablation.…”

Section: Rfa Fem Simulation and Experimental Evaluationmentioning

confidence: 99%

“…However, this was not the case for this gel phantom study.) The ablation zone was determined from the maximal transverse (W in cm) and longitudinal (L in cm) dimensions: the volume (V in cm 3 ) was calculated using the formula for ellipsoid volume, that is, V = (π/6)LW 2 [16]. Table 3 lists the volume and size measurements of RFA ablation, together with FEM simulation results.…”

Section: Experimental Validationmentioning

confidence: 99%

Image-based 3D modeling and validation of radiofrequency interstitial tumor ablation using a tissue-mimicking breast phantom

et al. 2012

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Purpose Minimally invasive treatment of solid cancers, especially in the breast and liver, remains clinically challenging, despite a variety of treatment modalities, including radiofrequency ablation (RFA), microwave ablation or highintensity focused ultrasound. Each treatment modality has advantages and disadvantages, but all are limited by placement of a probe or US beam in the target tissue for tumor ablation and monitoring. The placement is difficult when the tumor is surrounded by large blood vessels or organs. Patientspecific image-based 3D modeling for thermal ablation simulation was developed to optimize treatment protocols that improve treatment efficacy. Methods A tissue-mimicking breast gel phantom was used to develop an image-based 3D computer-aided design (CAD) model for the evaluation of a planned RF ablation. First, the tissue-mimicking gel was cast in a breast mold to create a 3D breast phantom, which contained a simulated solid tumor. Second, the phantom was imaged in a medical MRI scanner using a standard breast imaging MR sequence. Third, the MR images were converted into a 3D CAD model using commercial software (ScanIP, Simpleware), which was input into another commercial package (COMSOL Multiphysics) for RFA simulation and treatment planning using a finite element method (FEM). For validation of the model, the breast phantom was experimentally ablated using a commercial (RITA) RFA electrode and a bipolar needle with an electrosurgi- Results A 3D CAD model, created from MR images of the complex breast phantom, was successfully integrated with an RFA electrode to perform FEM ablation simulation. The ablation volumes achieved both in the FEM simulation and the experimental test were equivalent, indicating that patientspecific models can be implemented for pre-treatment planning of solid tumor ablation. Conclusion A tissue-mimicking breast gel phantom and its MR images were used to perform FEM 3D modeling and validation by experimental thermal ablation of the tumor. Similar patient-specific models can be created from preoperative images and used to perform finite element analysis to plan radiofrequency ablation. Clinically, the method can be implemented for pre-treatment planning to predict the effect of an individual's tissue environment on the ablation process, and this may improve the therapeutic efficacy.

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“…These factors combined are intended to result in larger lesions with a more uniform shape [12] and a reliable dose-effect relationship [13,14]. Advanced clinical experience with bipolar multiprobe RFA has primarily been obtained in the treatment of liver metastases [15][16][17], while its use for treatment of renal masses is currently described in only a few clinical studies [18][19][20][21][22]. To objectively assess the value of bipolar multiprobe RFA, the IDEAL recommendations were used [23].…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of bipolar radiofrequency ablation of small renal masses

et al. 2014

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all cases, the ablated volume was larger than the tumor. No viable cells were present within the ablated tissue. Conclusions Multipolar RFA is clinically successful for treating SRMs. Using preoperatively calculated energy settings, tailored size tumor lesions could be created. Clinical efficacy and oncological outcomes need to be investigated further in studies using multipolar RFA in a percutaneous fashion.

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In-Vivo Evaluation of a Novel Bipolar Radiofrequency Device for Interstitial Thermotherapy of Liver Tumors During Normal and Interrupted Hepatic Perfusion

Cited by 36 publications

References 47 publications

Ex situ quantification of the cooling effect of liver vessels on radiofrequency ablation

Ex situ quantification of the cooling effect of liver vessels on radiofrequency ablation

Image-based 3D modeling and validation of radiofrequency interstitial tumor ablation using a tissue-mimicking breast phantom

Clinical efficacy of bipolar radiofrequency ablation of small renal masses

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