In vivo evaluation of an injectable Macroporous Calcium Phosphate Cement

Valle, Sergio del; Miño, N.; Muñoz, Fernando; González, Antonio Ballesteros; Planell, Josep A.; Ginebra, Maria‐Pau

doi:10.1007/s10856-006-0700-y

Cited by 68 publications

(68 citation statements)

References 36 publications

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“…For example, as Biobone ® is more porous than BoneSource TM , the discovered diversity could be due to the differences in porosity [4,5]. The latter conclusion is confirmed by the results of other studies: a positive influence of the porosity on resorption rates was found [311]. The interested readers are referred to a study on the suitability of hardened and porous calcium orthophosphate formulations as scaffolds for bone regeneration, using a rabbit model [418].…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 61%

“…For example, an appropriate cohesion was achieved when no disintegration of the paste was observed in the fluid [153,308]. This can be accomplished by keeping a high viscosity for self-setting pastes [22] or using cohesion promoters (e.g., 1% aqueous solution of sodium alginate [200,310,311], as well as other chemicals [200,[312][313][314] (Table 3) are not injectable and blood must be kept away from the implanting site until setting [4,5]. A poor cohesion has been associated to a poor biocompatibility that might lead to inflammatory reactions [309].…”

Section: Rheological Propertiesmentioning

confidence: 99%

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Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 61%

Section: Rheological Propertiesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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“…9), which still offered satisfactory strength for bone cement application. Although the porous structure of set CO 3Ap cement obtained in this study might not enhance the mechanical property, it would increase resorbability and improve cell attachment 28) . In vivo experiments using the CO3Ap cement developed in this study have commenced.…”

Section: Discussionmentioning

confidence: 78%

Fabrication of bone cement that fully transforms to carbonate apatite

et al. 2015

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The objective of this study was to fabricate a type of bone cement that could fully transform to carbonate apatite (CO3Ap) in physiological conditions. A combination of calcium carbonate (CaCO3) and dicalcium phosphate anhydrous was chosen as the powder phase and mixed with one of three kinds of sodium phosphate solutions: NaH2PO4, Na2HPO4, or Na3PO4. The cement that fully transformed to CO3Ap was fabricated using vaterite, instead of calcite, as a CaCO3 source. Their stability in aqueous solutions was different, regardless of the type of sodium phosphate solution. Rate of transformation to CO3Ap in descending order was Na3PO4>Na2HPO4>NaH2PO4. Transformation rate could be affected by the pH of solution. Results of this study showed that it was advantageous to use vaterite to fabricate CO3Ap-forming cement.

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“…Micropores (<10µm) can be sufficient for circulation of body fluids but macroporosity (>100µm) is needed for cell colonization [47].…”

Section: Porositymentioning

confidence: 99%

Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Persson

Berg²

2012

J Mater Sci: Mater Med

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Currently available treatments for the degenerated intervertebral disc present disadvantages, such as surgical invasiveness and inadequate load distribution results. Load-bearing, injectable materials may be interesting for future therapies, but have not been studied in depth.In this study, the existing literature was screened for studies on injectable materials for the intervertebral disc and a rationale for load-bearing, injectable materials was formulated.Requirements for such a material were discussed, partly based on the experience of materials used for similar applications. Important properties were discussed and found to include biocompatibility, bioactivity, porosity, handling, injectability, working time, setting time, radiopacity, containment and mechanical properties, where several of these properties are linked to one another.Load--bearing injectables for the disc 2In conclusion, there is a need for consensus on the properties of new materials developed for use in minimally invasive procedures in the spine. A substantial amount of attention may need to be given to non-toxic setting reactions.

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In vivo evaluation of an injectable Macroporous Calcium Phosphate Cement

Cited by 68 publications

References 36 publications

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate Formulations

Fabrication of bone cement that fully transforms to carbonate apatite

Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

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