In vivo evaluation of cutaneous wound healing activity of Mirabilis jalapa L radix

Gogoi, Jyotchna; Nakhuru, Khonamai Sewa; Chattophadhayay, Pronobesh; Kumar, Ashok; Gogoi, Hemanta Kumar; Veer, Vijay

doi:10.1007/s13596-013-0122-6

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…number 1127/bc/07/CPCSEA) with Resolution (number 02/Scientist/Agrotech/DRL/2010-11). No toxicity was observed [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Wound contraction rate, epithelialisation period, and malondialdehyde (MDA) level were the parameters used for selection of single dose of F1 and F3 for comparative study of wound healing on excision wound model. 5% ointment formulation of MJE was found to be enhancing wound healing process [ 6 ]; thus, 5% ointment formulation was selected for comparative study. For F1, doses ranged from 0.1% to 0.3% and for F3, it ranged from 0.2% to 0.5% were used for selection of single dose.…”

Section: Methodsmentioning

confidence: 99%

“…Four new rotenoids mirabilijalones (A, B, C, and D) and 1,2,3,4-tetrahydro-1-methylisoquinoline-7,8-diol with anti-HIV activity were isolated from M. jalapa root [ 5 ]. Tuberous root of M. jalapa has been attributed to in vivo antimicrobial activity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, few tribes of Senapati district of Manipur (India) use M. jalapa roots for washing cuts and curing injury [ 7 ]. M. jalapa tuberous root extract showed cutaneous wound healing potential on both excision and dead space wound models in Wistar albino rat [ 6 ]. Phytochemicals such as terpenoids, phenolics, alkaloids, and flavonoids were detected in the crude extract of M. jalapa .…”

Section: Introductionmentioning

confidence: 99%

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Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root ofMirabilis jalapaL. on Excision Wound Model in Wistar Albino Rats

Gogoi

Nakhuru

Chattopadhayay

et al. 2014

International Scholarly Research Notices

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The study was designed to evaluate the effects of hydromethanolic extract of tuberous root of M. jalapa and its terpenoid and flavonoid fractions on cutaneous wound healing in Wistar Albino rats. The hydromethanolic extract was subfractionated by sequential extraction in solvents (moderately nonpolar to polar). The extract and its (terpenoid and flavonoid) fractions were used for cutaneous wound healing studies by using excision wound model on rat. Their effects on wound contraction rate, biochemical and histological changes, and expression of growth factors such as collagen 3A, basic fibroblast growth factor, and vascular endothelial growth factor were investigated. The results indicated that flavonoid treated group showed significant decrease (P < 0.05) in antioxidant enzyme level as compared to control in wound healing process, whereas terpenoid fraction showed significant increase (P < 0.05) in expression of growth factor levels but regeneration and remodeling stages were delayed due to formation of thicker ulcus layer and also there were no hair follicle-like blood capillaries formation which ultimately may lead to formation of hypertrophic scar of wound. Therefore, from this study, it can be concluded that terpenoid fraction prolongs proliferation phase and hence may have tendency to convert the wound into hypertrophic wound.

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“…number 1127/bc/07/CPCSEA) with Resolution (number 02/Scientist/Agrotech/DRL/2010-11). No toxicity was observed [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root ofMirabilis jalapaL. on Excision Wound Model in Wistar Albino Rats

Gogoi

Nakhuru

Chattopadhayay

et al. 2014

International Scholarly Research Notices

Self Cite

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“…Mirabilis jalapa Linn. from family Nyctaginaceae is known to possess various bioactivities, including antimicrobial, [2] antibacterial and antifungal, [3] antiviral and antiviroid, [4] antihelmintic, [5] antinociceptive, [6] anti-inflammatory, [7] wound healing, [8] hepato-protective, [9] hypoglycaemic [10] and hypolipidemic, [11] anti allergic and antiasthmatic [12].…”

Section: Introductionmentioning

confidence: 99%

HPLC Method Development and Validation for Quantitation of Trigonelline From Mirabilis Jalapa Linn. Leaves and Enhancement in Extraction Yield From Ultra Fine Powder

Sathe¹,

Dighe²

2016

Int J Curr Pharm Sci

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Objective: Development and validation of a simple and reliable HPLC method for determination of an alkaloid, trigonelline, in the methanolic extract of Mirabilis jalapa Linn. leaves and comparing the extraction yields of trigonelline from micro powder and ultrafine powder.Methods: The quantitation of trigonelline was carried out on a Phenomenex (Luna 5 U RP C8 (2) column, 25 cm x 4.6 mm, i.d. 5 µm), using mobile phase comprising of distilled water containing HCl (pH adjusted to 3.5) and methanol in the volume ratio of 70:30, which was delivered at the flow rate of 0.5 ml per min, at 35 °C column temperature. The detection and quantitation of trigonelline were carried out using PDA detector at the wavelength λ=264 nm.Ultra-fine powder of Mirabilis jalapa Linn. was prepared using simple stepwise powdering method. The dried leaves of Mirabilis jalapa Linn. were ground using ice jacketed domestic mixer. This powder was sieved through a BSS 85 mesh sieve and considered as a micro powder. Further fine grinding was done by jet milling, followed by ball milling. This powder was considered as an ultra-fine powder.Results: The proposed HPLC method for quantitation of trigonelline from dried leaf powder of Mirabilis jalapa Linn. is rapid, simple, accurate and precise.Conclusion: The amount of trigonelline obtained using methanolic extracts of Mirabilis jalapa Linn. Ultra-fine powder and the micro powder was found to be 1.1103 mg/g and 0.7258 mg/g respectively.

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Mirabilis jalapa

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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In vivo evaluation of cutaneous wound healing activity of Mirabilis jalapa L radix

Cited by 10 publications

References 16 publications

Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root ofMirabilis jalapaL. on Excision Wound Model in Wistar Albino Rats

Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root ofMirabilis jalapaL. on Excision Wound Model in Wistar Albino Rats

HPLC Method Development and Validation for Quantitation of Trigonelline From Mirabilis Jalapa Linn. Leaves and Enhancement in Extraction Yield From Ultra Fine Powder

Mirabilis jalapa

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