In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity

Xue, Weichang; Tao, Shunyan; Liu, Xuanyong; Zheng, Xuebin; Ding, Changfeng

doi:10.1016/s0142-9612(03)00545-3

Cited by 159 publications

(86 citation statements)

References 15 publications

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“…The degree of cyrstallinity also affects the solubility behavior of HAp. The dissolution property of the HAp coatings in Tris buffer has shown that coatings having high crystallinity had low dissolution rate compared to that of low crystallinity (Xue et al 2004). In accordance with these results, 5 % Ag-HAp, had high crystallinity (Table 1), hence lower solubility and lower rate of dissolution.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

et al. 2013

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Silver doped hydroxyapatite (Ag x Ca 100-x (PO 4 ) 6 (OH) 2 ) nanorods were synthesized using a modified sol gel method at a low temperature of 100°C. Silver concentration was varied as x = 1, 3 and 5. X-ray diffraction studies showed that the synthesized silver doped hydroxyapatite (Ag-HAp) was fully crystalline with hexagonal structure and an average crystallite size of 25 nm. At all the doping concentrations, the nanoparticles were rod shaped with an average length of 110-180 nm and diameter of 20-25 nm as determined from transmission electron microscopy (TEM) studies. These compounds were tested for their antimicrobial activities against E. coli (MTCC 2345) and S. aureus (MTCC 737). Antimicrobial activity was observed for all the three silver doping concentrations with the highest activity for x = 3, in terms of the zone of inhibition and the percentage reduction in the number of colonies. Hemolysis ratios for x = 1 and 3 Ag-HAp samples were below 2 %, indicating that they are highly hemocompatible and can be a promising biomaterial for tissue engineering applications in orthopedics.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

et al. 2013

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“…The Young`s modulus is a crucial parameter, as it ensures a strong connection between the implant and the bone [3]. The materials to bone regeneration should have a value of Young`s modulus similar or lower that of a natural human bone (15)(16)(17)(18)(19)(20) [12,13]. Poor mechanical properties caused the fast dissolution of the coatings in a physiological environment [31].…”

Section: Fig 2 Sem Images (With Different Magnifications) and Eds Smentioning

confidence: 99%

“…There are some reports on possible adverse e effects of both alloying elements of the Ti6Al4V: vanadium may provoke cytological responses and neurogenic disorders, and aluminum softens bone, do damage to nerve cells and disturbance of the function of enzymes [7][8][9][10]. The titanium alloy Ti13Zr13Nb possesses no harmful elements (aluminum and vanadium), is characterized by relatively low Young modulus (~ 80 GPa ) [8] compared to Ti6Al4V (~110 GPa) [11] and is more mechanically compatible with the bone (15)(16)(17)(18)(19)(20) [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…nanooxidation [8], laser treatment [14] or hydroxyapatite deposition [15]. Many deposition methods of hydroxyapatite/ nanohydroxyapatite were so far investigated, such as electrophoretic deposition (EPD) [16], plasma spraying [17], sol-gel methods [18] and biomimetic deposition [7]. In this research, the author obtained nanohydroxyapatite coatings on titanium alloy using electrophoretic deposition (EPD) method.…”

Section: Introductionmentioning

confidence: 99%

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The Properties of Nanosilver – Doped Nanohydroxyapatite Coating On the Ti13zr13Nb Alloy

Bartmański

2017

Advances in Materials Science

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The aim of this research was to study the properties of nanohydroxyapatite (nanoHAp) and nanohydroxyapatite, doped with nanosilver (nanoHAp/nanoAg), coatings obtained by an electrophoretic deposition process. The suspensions was prepared by dispersing 0.1 g of HAp nanopowder for nanoHAp coatings and 0.1 g of nanoHAp and 0.025 g nanoAg for nanoHAp/nanoAg coatings. The deposition was carried out for 1 min at 50 V voltage followed by drying at room temperature for 24 h and heating at 800°C for 1 h in vacuum. The thickness of the nanoHAp and nanoHAp/nanoAg coatings was found as of about 5 µm. The corrosion behavior tests made by potentiodynamic methods brought out slightly higher values of corrosion current for nanoHAp coatings and nanoHAp/nanoAg coatings as compared to the reference Ti13Zr13Nb specimen. The nanohardness of the nanoHAp coatings achieved 0.020 ± 0.004 GPa and of the nanoHAp/nanoAg coatings 0.026 ± 0.012 GPa. Nanoscratch test of the nanoHAp and nanoHAp/nanoAg coatings revealed an increased Critical Friction (mN) in the presence of nanosilver particles. The wettability angles decreased for nanoHAp/nanoAg coatings comparing to pure nanoHAp coatings on titanium alloy.

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“…Highly crystalline HA coatings (~92%) have been deposited using the MPS process (Ref 15), the lower thermal input of which enables the reduction of the overheating of powder particles and substrate. However, it must be said that the optimal phase composition of HA coatings remains open to discussion: crystalline HA is seen as a crucial factor for coatings' in vivo stability (Ref 16,17), but the presence of easily soluble ACP, TCP, or TTCP has been found to accelerate the bone attachment rate (Ref 18).…”

Section: Introductionmentioning

confidence: 99%

Low-Energy Plasma Spray (LEPS) Deposition of Hydroxyapatite/Poly-ε-Caprolactone Biocomposite Coatings

et al. 2011

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Thermal spraying is widely employed to deposit hydroxyapatite (HA) and HA-based biocomposites on hip and dental implants. For thick HA coatings (>150 lm), problems are generally associated with the build-up of residual stresses and lack of control of coating crystallinity. HA/polymer composite coatings are especially interesting to improve the pure HA coatings' mechanical properties. For instance, the polymer may help in releasing the residual stresses in the thick HA coatings. In addition, the selection of a bioresorbable polymer may enhance the coatings' biological behavior. However, there are major challenges associated with spraying ceramic and polymeric materials together because of their very different thermal properties. In this study, pure HA and HA/poly-e-caprolactone (PCL) thick coatings were deposited without significant thermal degradation by low-energy plasma spraying (LEPS). PCL has never been processed by thermal spraying, and its processing is a major achievement of this study. The influence of selected process parameters on microstructure, composition, and mechanical properties of HA and HA/PCL coatings was studied using statistical design of experiments (DOE). The HA deposition rate was significantly increased by the addition of PCL. The average porosity of biocomposite coatings was slightly increased, while retaining or even improving in some cases their fracture toughness and microhardness. Surface roughness of biocomposites was enhanced compared with HA pure coatings. Cell culture experiments showed that murine osteoblast-like cells attach and proliferate well on HA/PCL biocomposite deposits.

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In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity

Cited by 159 publications

References 15 publications

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

The Properties of Nanosilver – Doped Nanohydroxyapatite Coating On the Ti13zr13Nb Alloy

Low-Energy Plasma Spray (LEPS) Deposition of Hydroxyapatite/Poly-ε-Caprolactone Biocomposite Coatings

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