In vivo evaluation of spray formulations of human insulin for nasal delivery

Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats

“…19) Drug carriers which have bioadhesive properties and absorption-enhancing effects are suitable for the intranasal delivery of peptide drugs. 4,20) The aminated gelatins can be used as multifunctional delivery systems for peptide drugs.…”

“…1) The use of absorption enhancers 2) and proteolytic enzyme inhibitors 3) and suitably designed formulations 4) are needed to develop nasal delivery systems for peptide and protein drugs exhibiting higher bioavailability. The absorption enhancers, which increase the permeability of drugs through the epithelial membranes without causing any damage to them, are especially useful in designing new formulations.…”

In situ gels of Metoclopramide Hydrochloride for intranasal delivery: In vitro evaluation and in vivo pharmacokinetic study in rabbits

“…Study design. New Zealand white rabbits were selected as an experimental model because they provide a well controlled animal model for screening the nasal absorption potential of nasal formulations (Doneti et al, 1995, Desai et al, 1998. In a cross-over study with 1 week apart as a wash out period, 400 µl nasal in situ gel (equivalent to 10 mg MET HCl) was deposited into the both nostrils (200 µl into each nostril).…”

Development and Evaluation of Nasal Formulations of Ketorolac

“…By adding these materials to the drug in solution or powder preparations, drug absorption has been increased by extending the residence time in the nasal cavity (Harris et al 1989;Nagai et al 1984). Increased intranasal absorption of insulin was reported when insulin was mixed with a microcrystalline cellulose (MCC) (Dondeti et al 1995), and even greater absorption was achieved when freeze-dried insulin was mixed with carbopol 934P powder (Nagai et al 1984). It has been postulated that mucoadhesive polymers provide a relatively short-term adhesion between the drug and mucus and/or the epithelial cell surface (Peppas and Buri 1985;Park and Robinson 1984).…”