In vivo evaluation of tetrahedral amorphous carbon

LaVan, David A.; Padera, Robert F.; Friedmann, Thomas A.; Sullivan, John P.; Langer, Robert; Kohane, Daniel S.

doi:10.1016/j.biomaterials.2004.02.071

Cited by 31 publications

(20 citation statements)

References 26 publications

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“…On microscopy of stained sections, a mild inflammatory response was observed at both time points in the tissues directly adjacent to the device. Tissue reaction was consistent with what was reported for other implanted devices (11,35).…”

Section: Resultssupporting

confidence: 89%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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183

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A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained onstate drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.gold | nanoshell | poly(n-isopropylacrylamide) | ethylcellulose | diabetes

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Section: Resultssupporting

confidence: 89%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

183

175

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“…It would appear, however, that the hypothesis that superior elasticity leads to reduced toxicity [12,42] is incorrect in this case. We note that extremely inflexible materials, such as wafers of tetrahedral amorphous carbon and silicon, can show essentially no local toxicity after implantation [43]. …”

Section: Discussionmentioning

confidence: 99%

Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives

et al. 2011

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Cyanoacrylate glues are easily applied to wounds with good cosmetic results. However, they tend to be brittle and can induce local tissue toxicity. A series of cyanoacrylate monomers with a flexible ether linkage and varying side-chain lengths was synthesized and characterized for potential use as tissue adhesives. The effect of side-chain length on synthesis yield, physical and mechanical properties, formaldehyde generation, cytotoxicity in vitro and biocompatibility in vivo were examined. The incorporation of etheric oxygen allowed the production of flexible monomers with good adhesive strength. Monomers with longer side-chains were found to have less toxicity both in vitro and in vivo. Polymerized hexoxyethyl cyanoacrylate was more elastic than its commercially available and widely used alkyl analog 2-octyl cyanoacrylate, without compromising biocompatibility.

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“…The ta-C specimens were fabricated at Sandia National Laboratories using pulsed laser deposition (PLD) at room temperature [3]. The films were grown on top of a Si (100) substrate with a 2 µm thick SiO 2 sacrificial layer followed by a 0.1 µm polysilicon adhesion layer.…”

Section: A Specimen Fabricationmentioning

confidence: 99%

“…Compared to polysilicon ta-C has superior mechanical properties, such as hardness, wear resistance, stiffness (Young's modulus) and Poison's ratio [2]. The mechanical reliability and durability of ta-C is of critical importance for applications in electronic and biological devices [3,4]. However, mechanical reliability can be ensured with the thorough study of its failure strength and fracture toughness.…”

Section: Introductionmentioning

confidence: 99%

Mode–I Fracture Toughness of Tetrahedral Amorphous Diamond-like Carbon (ta-C) MEMS

et al. 2004

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Mode-I fracture toughness studies were conducted on hydrogen-free tetrahedral amorphous diamond-like carbon (ta-C) MEMS specimens of various thicknesses. Mathematically sharp edge pre-cracks were generated through micro indentation on the Silicon dioxide sacrificial layer. An atomic force microscope (AFM) was employed to measure the precise length and orientation of each pre-crack. Upon wet etching and release the freestanding uniform width and varying thickness MEMS-scale specimens were tested in Mode-I using a custom-made micro-tensile tester. Fracture toughness values were computed from the test data using linear elastic fracture mechanics (LEFM) for a finite width specimen with an edge crack in the fixed grip loading configuration. The average Mode-I fracture toughness for 0.5 micron thick specimens was found to be 4.25±0.7 MPa m while the average mode-I fracture toughness for 1 micron specimens was 4.4±0.4 MPa m .

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In vivo evaluation of tetrahedral amorphous carbon

Cited by 31 publications

References 26 publications

Near-infrared–actuated devices for remotely controlled drug delivery

Near-infrared–actuated devices for remotely controlled drug delivery

Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives

Mode–I Fracture Toughness of Tetrahedral Amorphous Diamond-like Carbon (ta-C) MEMS

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