In vivo evaluation of the highly soluble oral β-cyclodextrin–Sertraline supramolecular complexes

Passos, Joel J.; Sousa, Frederico B. De; Mundim, Iram Moreira; Bonfim, Ricardo Rodrigues; Melo, Robson L.; Viana, Alice Fialho; Stolz, Eveline Dischkaln; Borsoi, Milene; Rates, Stela Maris Kuze; Sinisterra, Rubén D.

doi:10.1016/j.ijpharm.2012.06.061

Cited by 18 publications

(9 citation statements)

References 29 publications

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“…The spectrum of βCD has characteristic bands at 3300 cm −1 (stretching vibrations of OH bond), 2925 cm −1 (CH stretch vibrations), 1151 cm −1 and 1023 cm −1 (symmetrical and asymmetrical stretching vibrations of C-O-C, respectively), as previously reported [25,26]. The HPβCD spectrum shows characteristic bands in the regions of 3355 cm −1 (OH stretching vibrations), 2922 cm −1 (CH bond stretching vibrations), 1151 cm −1 and 1080 cm −1 (stretching vibrations of C-H and C-O, respectively), as reported by Medarević’s [27].…”

Section: Resultssupporting

confidence: 77%

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

et al. 2019

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α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD’s as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.

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Section: Resultssupporting

confidence: 77%

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

et al. 2019

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“…CMO spectrum shows bands at 2926 and 2856 cm −1 (C–H stretching vibrations), 1693 cm −1 (C=O stretching vibrations), 1641 cm −1 (cycloalkenes C=C stretching vibrations), 1446 cm −1 (methyl C–H asymmetric deformation), 1365 cm −1 (methyl C–H symmetric deformation) and 887 cm −1 (out-of-plane alkenes C–H deformation), which are in accordance with bands reported by Silverstein [ 25 ]. β-CD spectrum ( Figure 2 ) shows characteristic bands at 3300 cm −1 (O–H stretching vibrations), 2925 cm −1 (C–H stretching vibrations), 1151 and 1023 cm −1 (C–O–C asymmetric and symmetric stretching vibrations, respectively), as reported by Abarca et al [ 26 ] and Passos et al [ 27 ]. Spectrum of HP-β-CD ( Figure 3 ) shows characteristic bands at 3355 cm −1 (O–H stretching vibrations), 2922 cm −1 (C–H stretching vibrations), 1151 and 1080 cm −1 (C–H and C–O stretching vibrations, respectively), as reported by Medarević et al [ 28 ].…”

Section: Resultssupporting

confidence: 75%

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Pinheiro

Tavares

Silva

et al. 2017

IJMS

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Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims to develop inclusion complexes of Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) and slurry (SL) methods. Physicochemical characterization was performed to verify the occurrence of interactions between CMO and the cyclodextrins. Carrageenan-induced hind paw edema in mice was carried out to evaluate the anti-inflammatory activity of CMO alone as well as complexed with CDs. Physicochemical characterization confirmed the formation of inclusion complex of CMO with both β-CD and HP-β-CD by KND and SL methods. Carrageenan-induced paw edema test showed that the anti-inflammatory activity of CMO was maintained after complexation with β-CD and HP-β-CD, where they were able to decrease the levels of nitrite and myeloperoxidase. In conclusion, this study showed that it is possible to produce inclusion complexes of CMO with CDs by KND and SL methods without any change in CMO’s anti-inflammatory activity.

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“…Also, characterization of sertraline:βCD complex in solid state indicates a formation of 1:1 IC. It is also shown that possible interactions of the sertraline molecule with CD molecules include N-methyl unit as well as aromatic rings, especially fused aromatic ring [31,32].…”

Section: Resultsmentioning

confidence: 99%

Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

et al. 2021

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The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1-0.5 µM with a limit of detection (LOD) of 2.0 × 10 -8 M and a limit of quantification (LOQ) of 6.7 × 10 -8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1-0.9 µM was obtained with a LOD of 2.6 × 10 -8 M and a LOQ of 8.8 × 10 -8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10 -8 and 8.6 × 10 -8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.

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In vivo evaluation of the highly soluble oral β-cyclodextrin–Sertraline supramolecular complexes

Cited by 18 publications

References 29 publications

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

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