In Vivo Evaluation of the Anti‐Inflammatory Effect of <i>Pistacia lentiscus</i> Fruit Oil and Its Effects on Oxidative Stress

Khedir, Sameh Ben; Mzid, Masarra; Bardaa, Sana; Moalla, Dorsaf; Sahnoun, Zouheir; Rebaï, Tarek

doi:10.1155/2016/6108203

Cited by 64 publications

(52 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous in vitro and in vivo studies have examined the antioxidant, anti-inflammatory, and anti-apoptotic potential of pistachio [21,[34][35][36][37][38]. In particular, the pistachio properties were tested on carrageenan or LPS-induced acute inflammatory response [39,40], inflammatory bowel disease, colitis [24,[41][42][43], cancer [44][45][46], and allergic inflammation in the asthmatic model [47]. To our knowledge, the present study was the first to explore the anti-inflammatory effects of pistachios in mice with HFD-induced obesity.…”

Section: Discussionmentioning

confidence: 99%

Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

Terzo

Mulè

Caldara

et al. 2020

IJMS

View full text Add to dashboard Cite

High-fat diet (HFD) induces inflammation and microbial dysbiosis, which are components of the metabolic syndrome. Nutritional strategies can be a valid tool to prevent metabolic and inflammatory diseases. The aim of the present study was to evaluate if the chronic intake of pistachio prevents obesity-associated inflammation and dysbiosis in HFD-fed mice. Three groups of male mice (four weeks old; n = 8 per group) were fed for 16 weeks with a standard diet (STD), HFD, or HFD supplemented with pistachios (HFD-P; 180 g/kg of HFD). Serum, hepatic and adipose tissue inflammation markers were analyzed in HFD-P animals and compared to HFD and STD groups. Measures of inflammation, obesity, and intestinal integrity were assessed. Fecal samples were collected for gut microbiota analysis. Serum TNF-α and IL-1β levels were significantly reduced in HFD-P compared to HFD. Number and area of adipocytes, crown-like structure density, IL-1β, TNF-α, F4-80, and CCL-2 mRNA expression levels were significantly reduced in HFD-P subcutaneous and visceral adipose tissues, compared to HFD. A significant reduction in the number of inflammatory foci and IL-1β and CCL-2 gene expression was observed in the liver of HFD-P mice compared with HFD. Firmicutes/Bacteroidetes ratio was reduced in HFD-P mice in comparison to the HFD group. A pistachio diet significantly increased abundance of healthy bacteria genera such as Parabacteroides, Dorea, Allobaculum, Turicibacter, Lactobacillus, and Anaeroplasma, and greatly reduced bacteria associated with inflammation, such as Oscillospira, Desulfovibrio, Coprobacillus, and Bilophila. The intestinal conductance was lower in HFD-P mice than in the HFD mice, suggesting an improvement in the gut barrier function. The results of the present study showed that regular pistachio consumption improved inflammation in obese mice. The positive effects could be related to positive modulation of the microbiota composition.

show abstract

Section: Discussionmentioning

confidence: 99%

Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

Terzo

Mulè

Caldara

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Inflammatory reactions are characterized by vascular hyperpermeability and cellular changes including enhancing ROS overproduction and the activation of inflammatory mediators in order to reduce the cellular injury [18]. The current treatments for the inflammatory disorders are coupled with undesirable side effects.…”

Section: Discussionmentioning

confidence: 99%

“…The carrageenaninduced paw edema is a well-established acute inflammation experimental model and has been used to estimate the potential anti-inflammatory impact of natural compounds. Indeed, carrageenan induction in the mice hind paw triggered intense inflammatory events characterized by oversecretion of numerous inflammatory mediators, temporary vasoconstriction, and vasodilatation, resulting in the development of edema and enlarged its size which peaked after 8 h [2,18]. In the present study, DADS was experimented for its potential anti-inflammatory and antioxidant effects against carrageenan-induced paw edema in mice.…”

Section: Discussionmentioning

confidence: 99%

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Zhang

Shang

Tian

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Diallyl disulfide (DADS) is the major organosulfur constituent in garlic, with a variety of pharmacological activities including antioxidant and anti-inflammatory. Here, we examined the potential antiedematous impact of DADS- versus carrageenan-mediated paw edema in mice. Carrageenan injection potentiated an inflammatory reaction as presented by the elevated serological C-reactive protein (CRP) levels and transcription of tumor necrosis factor-alpha (TNF-α, Tnfα), interleukin-1 beta (IL-1β, Il1b), interleukin-2 (IL-2, Il2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX-2, Ptgs2), prostaglandin E2 (PGE2), monocyte chemoattractant protein-1 (MCP-1, Ccl1), nuclear factor kappa B (NF-κB), and myeloperoxidase (MPO) activity, while interleukin-10 (IL-10) was declined in the injured paw tissue. Additionally, carrageenan elevated lipid peroxidation in terms of malondialdehyde (MDA) and decreased glutathione content (GSH). Remarkably, DADS was found to inhibit the inflammatory signaling, suppressed the developed oxidative damage, and protected the histopathological alterations in the inflamed paw tissue in response to carrageenan injection. Our findings suggest that DADS could be used as an alternative therapy used to alleviate the pathophysiological changes associated with the genesis of paw edema through its potent anti-inflammatory and antioxidant impacts.

show abstract

“…Local inflammation that induced by Carrageenan was reported to be associated with the production of ROS and to play a vital role in the creation of oxidative stress. [38] In this study, biochemical investigations clarified that Cg treatment caused increasing with high significant (0.001) in the level of MDA with as compared with the control group while the levels of SOD and GSH are decreased in comparing with the same group. In Cg Met, Cg Cocoa and Cg Met Cocoa groups, all levels of MDA decreased with high significant value (0.001) in comparison with Cg group while the mean of SOD and GSH are elevated with high significant value (0.001) in comparison with Cg group.…”

Section: Acknowledgementmentioning

confidence: 57%

Synergistic Effects of Metformin and Cocoa Flavanol on Inflammatory and Oxidant Markers Induced by Carrageenan: Pathophysiological Approach

Abdelsalam

2019

IJCEP

View full text Add to dashboard Cite

Background and Aim: The present study aims to evaluate the effects of metformin, cocoa flavanol and their combination as anti-inflammatory and antioxidant drugs. Methods: Forty adult male albino mice are divided into five groups: Control, Carrageenan (Cg), Cg Metformin (Met), Cg Cocoa and Cg Met Cocoa groups. Cg is used to induce the inflammation through injection of it in the paw of the hind leg and into the trunk of mice. Also, Met is applied intraperitoneally at the same time of Cg injection while Cocoa is received orally seven days before carrageenan injection. Biochemical estimation of inflammatory mediators (COX-2, PGE2, TNF-α, CRP) and selected oxidative stress markers (MDA, SOD, GSH) was performed. Results: This study elucidated the marvellous leverage of the metformin, cocoa flavanol and their combination as anti-inflammatory and antioxidant drugs, where metformin and Cocoa decreased all inflammatory mediators (COX-2, PGE2, TNF-α, CRP) with high significant (P<0.01) in comparing with Cg group. In addition, the level of MDA is decreased significantly (P<0.01), while the levels of SOD and GSH are increased significantly (P<0.01) in comparing with Cg group. Interestingly, their combination restored normal levels of the inflammatory mediators and the oxidative stress markers. Conclusion: I concluded that Met and cocoa are powerful anti-inflammatory substances and can ameliorate the oxidative stress that results from inflammation. Additionally, the mixture of them can retrieve the normal levels of all measured parameters.

show abstract

In Vivo Evaluation of the Anti‐Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress

Cited by 64 publications

References 57 publications

Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Synergistic Effects of Metformin and Cocoa Flavanol on Inflammatory and Oxidant Markers Induced by Carrageenan: Pathophysiological Approach

Contact Info

Product

Resources

About