In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland

Buaas, F. William; Gardiner, Jennifer R.; Clayton, Sally A.; Val, Pierre; Swain, Amanda

doi:10.1242/dev.087247

Cited by 73 publications

(62 citation statements)

References 41 publications

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“…The orphan nuclear receptor SF1 is known to activate cytochrome p450 genes [24], and sf1 gene knockout studies have reported that SF1 regulates the expression of steroidogenic genes in steroid-producing cells and that ablation of SF1 leads to a loss in cell morphology and cell identity in the ovary [25]. In addition, Sf1 has also been shown to mediate the release of estradiol from granulosa cells [16].…”

Section: Discussionmentioning

confidence: 99%

Adrenomedullin2 (ADM2)/Intermedin (IMD) in Rat Ovary: Changes in Estrous Cycle and Pregnancy and Its Role in Ovulation and Steroidogenesis1

Chauhan

Balakrishnan

Selvanesan

et al. 2015

Biology of Reproduction

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Adrenomedullin2 (ADM2) is reported to facilitate embryo implantation and placental development. Therefore, the current study was undertaken to identify if ADM2 has a functional role in ovary to facilitate its reproductive actions. This study shows that the expression of ADM2 is differentially regulated in rat estrous cycle and that ADM2 increases the synthesis and secretion of 17beta-estradiol accompanied with an increase in the expression of steroidogenic factor 1 (Sf1), estrogen receptor Esr1, and enzymes involved in steroidogenesis in equine chorionic gonadotropin (eCG)-treated rat ovaries. In addition, inhibition of endogenous ADM2 function in eCG-treated immature rats caused impaired ovulation. Furthermore, the mRNA expression of Adm2 and receptor activity modifying protein 3 is higher in the ovary on Day 18 compared to nonpregnant and pregnant rats on Day 22. ADM2-like immunoreactivity is localized in granulosa cells, blood vessels, oocytes, cumulous oophorus, and corpus luteum of pregnant ovaries, suggesting a potential role for ADM2 in the ovary. This is supported by the presence of ADM2-like immunoreactivity in the corpus luteum during pregnancy and a decline in aromatase immunoreactivity in corpus luteum on Day 9 of gestation in rats infused with ADM2 antagonist during implantation and decidualization phase. Taken together, this study suggests a potential involvement of ADM2 in the rat ovary in regulating synthesis of estradiol to support ovulation and facilitate efficient implantation and placental development for a successful pregnancy.

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Section: Discussionmentioning

confidence: 99%

Adrenomedullin2 (ADM2)/Intermedin (IMD) in Rat Ovary: Changes in Estrous Cycle and Pregnancy and Its Role in Ovulation and Steroidogenesis1

Chauhan

Balakrishnan

Selvanesan

et al. 2015

Biology of Reproduction

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“…Zubair et al Zubair et al, 2008) showed that a fetal adrenocorticalspecific enhancer (FAdE) activates and maintains nuclear receptor subfamily 5, group A, member 1 (Nr5a1, also known as Sf1 or Ad4bp) expression only in the fetal adrenal gland. Nr5a1 encodes steroidogenic factor 1 (Sf1), an essential transcription factor for steroidogenesis, proliferation and differentiation of adrenocortical cells (Bland et al, 2004;Buaas et al, 2012;Fatchiyah et al, 2006;Katoh-Fukui et al, 2005;Lala et al, 1992;Luo et al, 1994;Morohashi et al, 1992;Rice et al, 1991;Sadovsky et al, 1995;Val et al, 2007). The adult cortex emerges between the fetal cortex and capsule, ultimately replacing the regressing fetal cortex.…”

Section: Introductionmentioning

confidence: 99%

Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus

et al. 2013

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The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descendants within the adrenal capsule express Gli1, a known marker of progenitors of steroidogenic adrenal cells. The capsule is also populated by cells that express Tcf21, a known inhibitor of Nr5a1 gene expression. We demonstrate that Tcf21-expressing cells give rise to Nr5a1-expressing cells but only before capsular formation. After the capsule has formed, capsular Tcf21-expressing cells give rise only to non-steroidogenic stromal adrenocortical cells, which also express collagen 1a1, desmin and platelet-derived growth factor (alpha polypeptide) but not Nr5a1. These observations integrate prior observations that define two separate origins of adult adrenocortical steroidogenic cells (fetal adrenal cortex and/or the adrenal capsule). Thus, these observations predict a unique temporal and/or spatial role of adult cortical cells that arise directly from either fetal cortical cells or from fetal cortex-derived capsular cells. Last, the data uncover the mechanism by which two populations of fetal cells (fetal cortex derived Gli1-expressing cells and mesenchymal Tcf21-expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex.

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“…The mechanisms underlying the differentiation of FLCs have been studied extensively, and the involvement of transcription factors [Meeks et al, 2003;Cui et al, 2004;Buaas et al, 2012;van den Driesche et al, 2012;Miyabayashi et al, 2013] and growth factors [Yao et al, 2002;Brennan et al, 2003;Tang et al, 2008] has been determined. Both Leydig cell types display morphological and functional differences in addition to developmental timing; interestingly, this includes the capability for steroid production.…”

mentioning

confidence: 99%

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

Miyabayashi

Shima

Inoue³

et al. 2016

Sex Dev

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Fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) develop in the mammalian prenatal and postnatal testes, respectively. In mice, FLCs emerge in the interstitial space of the testis as early as embryonic day 12.5 and thereafter increase in number during the fetal stage. We previously established a transgenic mouse line in which FLCs are labeled with EGFP and demonstrated that the EGFP-labeled FLCs were present even in adult testes. However, the characteristics of FLCs during postnatal stages remained unclear. In the present study, a comparison of the transcriptomes of FLCs from prenatal and postnatal testes and of ALCs from adult testes revealed that FLCs gradually alter their characteristics across developmental stages and come to roughly resemble ALCs. Many cholesterogenic genes simultaneously expressed a unique alternation pattern, while many oxidative phosphorylation and β-oxidation (both mitochondrial functions) genes showed a different unique pattern. These metabolic gene expression alterations might be triggered by milieu changes, such as nutrient and oxygen supply, from the prenatal to the postnatal period.

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In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland

Cited by 73 publications

References 41 publications

Adrenomedullin2 (ADM2)/Intermedin (IMD) in Rat Ovary: Changes in Estrous Cycle and Pregnancy and Its Role in Ovulation and Steroidogenesis1

Adrenomedullin2 (ADM2)/Intermedin (IMD) in Rat Ovary: Changes in Estrous Cycle and Pregnancy and Its Role in Ovulation and Steroidogenesis1

Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

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