In vivo evidence that erythropoietin has a neuroprotective effect during subarachnoid hemorrhage

Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis

“…42 Epo acts as the main regulator of proliferation and differentiation of erythroid progenitor cells in the bone marrow. 13 Neuroprotective effects of systemically administered Epo have been shown in animal models of focal cerebral ischemia, traumatic brain injury, subarachnoid hemorrhage, and spinal cord injury, 19,[43][44][45] but the relevance of the underlying molecular mechanisms in vivo remained still unclear. Additionally, Epo treatment rescued RGCs from apoptosis in a retinal ischemia model and improved RGC function determined by ERG recordings.…”

Cognitive Recovery and Rehabilitation After Brain Injury: Mechanisms, Challenges and Support

“…The close association between EPO and blood-related processes originally provoked a primary research focus around the use of EPO in vascular brain injury (e.g. Alafaci et al, 2000;Brines et al, 2000;Buemi et al, 2000;Calapai et al, 2000;Grasso, 2001;Siren et al, 2001;Springborg et al, 2002). Subsequently, however, it turned out that EPO possesses a strong therapeutic potential even in TBI -including the ability to reduce posttraumatic cognitive impairments and support the cognitive rehabilitative processes (e.g.…”

Erythropoietin for the Treatment of Subarachnoid Hemorrhage: A Feasible Ingredient for a successful Medical Recipe

“…In particular, analysis of cortical neurons showed that the EPOtreated rabbits presented with a significant decrease in the amount of necrotic neurons compared with the untreated and placebo-treated animals (80). Another outcome, and prevents brain ischemic damage (37,38,(80)(81)(82)(83)(84)(85)(86)(87)(88). Given these findings, and according to reports that have demonstrated that EPO enhances the NO system activity (27,68,69), and neuroprotective effects on cerebral cortical neurons from N-methyl-d-aspartate receptormediated glutamate toxicity (71), we further investigated the potential protective effects of rHuEPO in a rabbit model of SAH.…”