2005
DOI: 10.1016/j.tox.2005.07.009
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In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: Protection by erdosteine

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Cited by 138 publications
(143 citation statements)
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“…Of the 44 patients who received intravenous contrast dye, 10 (22.7%) experienced nephrotoxicity. Interestingly, in animal studies, both intravenous contrast dye 37,38 and highdose vancomycin 15,16 have been demonstrated to promote free radical formation within renal tissue, which is hypothesized to cause tubular damage primarily through vascular endothelial dysfunction, vasoconstriction, and subsequent reperfusion injury. N-acetylcysteine is frequently administered to patients about to receive intravenous contrast dye (although its benefit remains controversial 37,39 ); N-acetylcysteine has also been shown in an animal model to attenuate vancomycin-induced renal injury.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Of the 44 patients who received intravenous contrast dye, 10 (22.7%) experienced nephrotoxicity. Interestingly, in animal studies, both intravenous contrast dye 37,38 and highdose vancomycin 15,16 have been demonstrated to promote free radical formation within renal tissue, which is hypothesized to cause tubular damage primarily through vascular endothelial dysfunction, vasoconstriction, and subsequent reperfusion injury. N-acetylcysteine is frequently administered to patients about to receive intravenous contrast dye (although its benefit remains controversial 37,39 ); N-acetylcysteine has also been shown in an animal model to attenuate vancomycin-induced renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…14 The effect of higher trough levels on kidney function remains poorly understood, as does the mechanism of vancomycin-induced renal injury itself, though animal studies demonstrate oxidative damage to renal tubules with high doses of vancomycin. 15,16 In previous studies, the incidence of vancomycin nephrotoxicity with lower troughs has been reported to range from 0% to 19% with vancomycin alone, increasing up to 35% with concomitant aminoglycoside therapy. [17][18][19][20][21][22][23][24] Limited studies have been done to assess the risk of nephrotoxicity at higher trough levels.…”
mentioning
confidence: 99%
“…NADPH is used by GSH to maintain the reduced state of cell GSH (42). The enzyme level of CAT is higher in proximal tubules to prevent excessive oxidant stress (43). The free radicals may induce the inactivation and consumption of CAT in renal tissue in MTX-treated rats.…”
Section: Ge+mtxmentioning
confidence: 99%
“…It has been suggested that VCM-induced oxidative stress results in the tubular damage. 43 Given its widespread use, clinicians should be aware of this risk and should monitor patients for development of nephrotoxicity. Overall risk for nephrotoxicity is difficult to pinpoint as there is wide variability within the reported numbers from different studies.…”
Section: Antimicrobial Agents Aminoglycosidesmentioning
confidence: 99%