In Vivo Experiment on the Metabolism of Cesium in Human Blood with Reference to Rubidium and Potassium

Cesium

“…In rats almost 98% of the cesium is absorbed in the stomach during the first 2 hours after ingestion (Burkhardt and Wirth, 1986). Muscle tissue uptakes cesium from blood about two-fold better than potassium, whereas in erythrocytes the cesium uptake is strongly diminished (Yamagata et al, 1966). Large variations in the cesium concentrations of different heart tissues of young steers were observed (ranging from 6.0 to 801 mg kg À1 fresh matter) (Webb et al, 1976) and this corresponds with data obtained in pig hearts.…”

“…A high intake of cesium is rapidly excreted via the kidneys (Yamagata et al, 1966), and consequently no reports have been made on any chronic effects due to stable cesium intake. Neither have any mutagenic, carcinogenic or teratogenic effects of stable cesium been either studied or described.…”

Rubidium and Potassium Concentrations in Human Erythrocytes, Plasma, and Urine.

“…taken orally were also performed (Mays and Lloyd, 1968 The results for the plasma Rb concentration were » fairly good agreement with values reported by Lang (1965) and Yamagata and Iwashima (1966) and in poor agreement with values given by Bertrand and Bertrand (1951). Bertrand and Bertrand, employing spectrophotometry, listed a value for j .…”

A Biokinetic Model for Rb in Humans

“…Autoradiographic results indicate that skeletons of rodents contained a larger portion of injected 43K than injected 86Rb at one hour (Olsson et al 1969). Measurements of natural Rb in rib and in soft tissues of the human body indicate that the quotient of concentrations Rb/K for rib including marrow is about halfthe quotient Rb/K for the rest of the body (Yamagata et al 1966). The affinity of Rb for cartilage may be as high or higher than that of K (Love et al 1954); this may be of more importance In describing behavior of skeletal Rb in children than in adults because only a small portion of the adult skeleton's K resides in cartilage (Williams and Leggett 1987).…”

“…We have revised our earlier estimate (Leggett and Williams 1986) of the rate of cell sloughing from the GI tract walls to contents (Lipkin 1965;ICRP 1975), so the percentage of GI tract Rb lost by this pathway differs from our earlier estimate for K (Leggett and Williams 1986). The level of intake in diet is based on the amount lost in urine (Williams and Leggett 1987) and the assumption that 75% of the total steady-state loss is in urine (Ray et al 1955;Wood 1968;Yamagata et al 1966; Berenson and Burch 1957). Absorption of Rb from the stomach to blood is assumed to be negligible.…”