In vivo exposure of marine mussels to venlafaxine: bioconcentration and metabolization

Góméz, Elena; Boillot, Clotilde; Bueno, María Jesús Martínez; Munaron, Dominique; Mathieu, Olivier; Courant, Frédérique; Fenet, Hélène

doi:10.1007/s11356-021-14893-4

Cited by 13 publications

(4 citation statements)

References 36 publications

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“…Gomez et al (2021) studied the bioconcentration of VLF in marine mussels ( M. galloprovincialis ) and showed that mussels accumulate VLF following first order kinetics [ 51 ]. At 10 µg/L exposure concentration, VLF was quantified in mussel tissues at around 1200 ng/g dw on the first day of exposure, then increasing to more than 2000 ng/g dw on the seventh day of exposure.…”

Section: Discussionmentioning

confidence: 99%

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

et al. 2022

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There is growing evidence of the presence of pharmaceuticals in natural waters and their accumulation in aquatic organisms. While their mode of action on non-target organisms is still not clearly understood, their effects warrant assessment. The present study assessed the metabolome of the Mediterranean mussel (Mytilus galloprovincialis) exposed to a 10 µg/L nominal concentration of the antidepressant venlafaxine (VLF) at 3 time-points (1, 3, and 7 days). Over the exposure period, we observed up- or down-modulations of 113 metabolites, belonging to several metabolisms, e.g., amino acids (phenylalanine, tyrosine, tryptophan, etc.), purine and pyrimidine metabolisms (adenosine, cyclic AMP, thymidine, etc.), and several other metabolites involved in diverse functions. Serotonin showed the same time-course modulation pattern in both male and female mussels, which was consistent with its mode of action in humans, i.e., after a slight decrease on the first day of exposure, its levels increased at day 7 in exposed mussels. We found that the modulation pattern of impacted metabolites was not constant over time and it was gender-specific, as male and female mussels responded differently to VLF exposure.

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Section: Discussionmentioning

confidence: 99%

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

et al. 2022

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“…After 7 days of depuration, a rapid decrease in the tissue concentration to 21 ± 1.0 ng/g dw was observed (58). After exposure to different concentrations of venlafaxine (1, 10 and 100 μg/L), metabolites were found in mussel tissues, namely N-desmethylvenlafaxine and O-desmethylvenlafaxine; also N,O-didesmethylvenlafaxine and N,N-didesmethylvenlafaxine were detected after exposure to the highest concentrations (58). These data indicate that M. galloprovincialis takes up venlafaxine and actively metabolises the drug.…”

Section: The Serotonergic System As a Target For Aquatic Contaminants...mentioning

confidence: 99%

“…These data indicate that M. galloprovincialis takes up venlafaxine and actively metabolises the drug. Among metabolites, at least N-desmethylvenlafaxine was reported to contribute to the therapeutic effects of venlafaxine in humans (58). The ability of mussels to uptake and metabolize venlafaxine has been confirmed by targeted and non-targeted approaches using liquid chromatography combined with high-resolution mass spectrometry to screen for expected metabolites based on the literature on aquatic species, and for metabolites not previously documented (59).…”

Section: The Serotonergic System As a Target For Aquatic Contaminants...mentioning

confidence: 99%

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

et al. 2022

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Contaminants of Emerging Concerns (CECs) are defined as chemicals not commonly monitored in aquatic ecosystems, but with the potential to cause adverse effects on biota. CECs include Endocrine Disrupting Chemicals (EDCs) and Neuro-Endocrine disruptors (NEDs) of vertebrates. However, most invertebrates only rely on neuroendocrine systems to maintain homeostatic processes. Although conserved neuroendocrine components have been characterized in ecologically relevant groups, limited knowledge on invertebrate neuroendocrinology makes it difficult to define EDCs and NEDs in most species. The monoamine serotonin (5-hydroxytryptamine, 5-HT) acts both as a neurotransmitter and as a peripheral hormone in mammals. In molluscs, 5-HT is involved in multiple physiological roles and molecular components of the serotonergic system have been identified. This review is focused on the effects of CECs on the serotonergic system of bivalve molluscs. Bivalves are widespread in all aquatic environments, estuarine and coastal areas in particular, where they are exposed to a variety of chemicals. In bivalves, 5-HT is involved in gametogenesis and spawning, oocyte maturation and sperm motility, regulates heart function, gill ciliary beating, mantle/siphon function, the ‘‘catch’’ state of smooth muscle and immune responses. Components of 5-HT transduction (receptors and signaling pathways) are being identified in several bivalve species. Different CECs have been shown to affect bivalve serotonergic system. This particularly applies to antidepressants, among the most commonly detected human pharmaceuticals in the aquatic environment. In particular, selective serotonin reuptake inhibitors (SSRIs) are frequently detected in seawater and in bivalve tissues. Information available on the effects and mechanisms of action of SSRIs on the serotonergic system of adult bivalves is summarized. Data are also reported on the effects of CECs on development of neuroendocrine pathways of early larval stages, in particular on the effects of model EDCs in the marine mussel Mytilus galloprovincialis. Overall, available data point at the serotonergic system as a sensitive target for neuroendocrine disruption in bivalves. The results contribute drawing Adverse Outcome Pathways (AOPs) for model EDCs and SSRIs in larvae and adults. However, basic research on neuroendocrine signaling is still needed to evaluate the potential impact of neuroendocrine disruptors in key invertebrate groups of aquatic ecosystems.

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“…Most bivalves live at the water–sediment interface, exhibit burrowing behaviours, and are filter feeders (McLeod, Luoma & Luthy, 2008). These features lead them to accumulate various chemical pollutants including metals (Rzymski et al ., 2014; Shi et al ., 2016; Yuan et al ., 2020), PCBs (Dodoo, Essumang & Jonathan, 2013; Milun et al ., 2020), PAHs (Yap, Shahbazi & Zakaria, 2012; Yoshimine & Carreira, 2012), organochlorine pesticides (Tong et al ., 2019), per‐ and polyfluoroalkyl substances (Cui et al ., 2021), and pharmaceuticals released into the environment (Gomez et al ., 2021). Mytilus edulis (Fig.…”

Section: Key Aquatic Invertebrates In Standardised Aquatic Ecotoxicol...mentioning

confidence: 99%

A broad‐taxa approach as an important concept in ecotoxicological studies and pollution monitoring

Rosner,

Ballarin,

Barnay‐Verdier

et al. 2023

Biological Reviews

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Aquatic invertebrates play a pivotal role in (eco)toxicological assessments because they offer ethical, cost‐effective and repeatable testing options. Additionally, their significance in the food chain and their ability to represent diverse aquatic ecosystems make them valuable subjects for (eco)toxicological studies. To ensure consistency and comparability across studies, international (eco)toxicology guidelines have been used to establish standardised methods and protocols for data collection, analysis and interpretation. However, the current standardised protocols primarily focus on a limited number of aquatic invertebrate species, mainly from Arthropoda, Mollusca and Annelida. These protocols are suitable for basic toxicity screening, effectively assessing the immediate and severe effects of toxic substances on organisms. For more comprehensive and ecologically relevant assessments, particularly those addressing long‐term effects and ecosystem‐wide impacts, we recommended the use of a broader diversity of species, since the present choice of taxa exacerbates the limited scope of basic ecotoxicological studies.This review provides a comprehensive overview of (eco)toxicological studies, focusing on major aquatic invertebrate taxa and how they are used to assess the impact of chemicals in diverse aquatic environments. The present work supports the use of a broad‐taxa approach in basic environmental assessments, as it better represents the natural populations inhabiting various ecosystems. Advances in omics and other biochemical and computational techniques make the broad‐taxa approach more feasible, enabling mechanistic studies on non‐model organisms. By combining these approaches with in vitro techniques together with the broad‐taxa approach, researchers can gain insights into less‐explored impacts of pollution, such as changes in population diversity, the development of tolerance and transgenerational inheritance of pollution responses, the impact on organism phenotypic plasticity, biological invasion outcomes, social behaviour changes, metabolome changes, regeneration phenomena, disease susceptibility and tissue pathologies. This review also emphasises the need for harmonised data‐reporting standards and minimum annotation checklists to ensure that research results are findable, accessible, interoperable and reusable (FAIR), maximising the use and reusability of data. The ultimate goal is to encourage integrated and holistic problem‐focused collaboration between diverse scientific disciplines, international standardisation organisations and decision‐making bodies, with a focus on transdisciplinary knowledge co‐production for the One‐Health approach.

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In vivo exposure of marine mussels to venlafaxine: bioconcentration and metabolization

Cited by 13 publications

References 36 publications

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

A broad‐taxa approach as an important concept in ecotoxicological studies and pollution monitoring

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