In vivo fate and scavenger receptor recognition of oxidized lipoprotein[a] isoforms in rats.

Rijke, Yolanda B. de; Jürgens, Günther; Hessels, E. M. A. J.; Hermann, Anita; Berkel, Theo J.C. Van

doi:10.1016/s0022-2275(20)40545-0

Cited by 35 publications

(1 citation statement)

References 42 publications

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“…Thrombosis may be augmented by Lp(a) binding and then inhibiting tissue factor pathway inhibitor (TFPI), which is a potent inhibitor of the tissue factor mediated coagulation cascade 74 . Also, Lp(a) has been demonstrated to regulate platelet activation and aggregation triggered by various agonists, as well as to associate with others prothrombotic proteins, such as α2macroglobulin (α plasmin inhibitor) and serine proteinase inhibitor A1 (SERPINA, a tPA inhibitor) 75 .…”

Section: Physiological Functions Of Lp(a)mentioning

confidence: 99%

Lipoprotein(a): An update on its role in human health and disease

Koutsogianni¹,

Liberopoulos²,

Tselepis³

2021

JAPT

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Over the past few years, there has been an undiminished interest on lipoprotein(a) [Lp(a)]. High Lp(a) levels have been proposed as an independent causal risk factor for atherosclerotic cardiovascular disease (CVD). The main question that remains to be answered, however, is the potential clinical benefit of Lp(a) reduction. This will contribute to the enrichment of our knowledge on the exact pathophysiological role of this lipoprotein. This narrative review aims to summarize currently available data on the structure, metabolism, and pathogenicity of Lp(a).

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Section: Physiological Functions Of Lp(a)mentioning

confidence: 99%

Lipoprotein(a): An update on its role in human health and disease

Koutsogianni¹,

Liberopoulos²,

Tselepis³

2021

JAPT

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Lipoprotein(a): A missing culprit in the management of athero‐thrombosis?

Ferretti

Bacchetti

Johnston

et al. 2017

Journal Cellular Physiology

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Lipoprotein(a) Lp(a) is a cholesterol-rich, LDL-like particle that is independently associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis, and stroke. Genetic variation in the Lp(a) locus and some other genes related to Lp(a) synthesis and metabolism play a critical role in regulating plasma Lp(a) levels. The pathophysiological potential of Lp(a) is related to proatherogenic and prothrombotic effects on the vasculature. Different molecular mechanisms underlying the atherothrombotic potential of Lp(a), free apolipoprotein(a), and oxidized-Lp(a) have been proposed. However, plasma Lp(a) assay is complicated by problems associated with quantification and standardization owing to the polymorphic nature of this lipoprotein. This review has focused on the physicochemical properties of Lp(a), the genetic aspects of Lp(a), the need for accurate determination of Lp(a), the synthesis, and recent findings on metabolism of Lp(a). Lastly, the patho-physiological mechanisms by which Lp(a) may increase athero-thrombosis and an overview on the therapeutic modalities to interfere with Lp(a) are summarized.

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Role of lipoproteins in progression of coronary arteriosclerosis

Berkel¹

1996

Developments in Cardiovascular Medicine

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In vivo fate and scavenger receptor recognition of oxidized lipoprotein[a] isoforms in rats.

Cited by 35 publications

References 42 publications

Lipoprotein(a): An update on its role in human health and disease

Lipoprotein(a): An update on its role in human health and disease

Lipoprotein(a): A missing culprit in the management of athero‐thrombosis?

Role of lipoproteins in progression of coronary arteriosclerosis

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