In vivo free‐breathing DTI and IVIM of the whole human heart using a real‐time slice‐followed SE‐EPI navigator‐based sequence: A reproducibility study in healthy volunteers

Moulin, Kévin; Croisille, Pierre; Feiweier, Thorsten; Delattre, Bénédicte; Wei, Hongjiang; Robert, Benjamin; Beuf, Olivier; Viallon, Magalie

doi:10.1002/mrm.25852

Cited by 52 publications

(71 citation statements)

References 51 publications

(70 reference statements)

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“…Finally, the IVIM model is a nonlinear model of 2 diffusion compartments in which the relative weight of the pseudo‐diffusion compartment is about 1/10th of the dominant diffusion compartment. Echocardiographic data has revealed a volume fraction of blood in myocardium of 12.6% ± 1.8% healthy individuals at rest, which is confirmed by IVIM‐derived perfusion fractions of 12.2% ± 1.3% and 13.1 ± 6.00% . Accordingly, parameter fitting of low SNR data may lead to potential bias and variation because of the intrinsic model nonlinearity and the relatively weak contribution of the perfusion compartment to total signal attenuation.…”

Section: Introductionmentioning

confidence: 72%

“…An alternative to the IVIM tensor model is the IVPCM model, which parameterizes anisotropy with only 1 parameter (concentration of the von Mises distribution). Further investigations into IVIM can also consider the T 1 and T 2 relaxation effects to account for the different contributions of the compartments for different sequences and their respective timing parameters …”

Section: Discussionmentioning

confidence: 99%

“…Considering both diffusion and perfusion, the IVIM model results in a biexponential model of the image magnitude as a function of diffusion weighting. The model has frequently been used to fit data acquired in a variety of anatomical regions including abdomen, heart, and brain …”

Section: Introductionmentioning

confidence: 99%

“…It was shown that the measured perfusion parameters depend on the diffusion encoding gradient direction; they increase during adenosine administration and approach noise levels postmortem. Human hearts were studied with spin‐echo (SE) sequences triggered to a range of diastolic time points with subsequent filtering and maximum intensity projection through time . In vivo human data was also obtained using second‐order motion‐compensated SE‐DWI triggered to systole with consecutive hierarchical Bayesian IVIM parameter estimation .…”

Section: Introductionmentioning

confidence: 99%

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On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI

Spinner

Stoeck

Mathez

et al. 2019

Magnetic Resonance in Med

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Purpose: Mapping intravoxel incoherent motion (IVIM) in the heart remains challenging despite advances in cardiac DWI and DTI. In the present work, simulations and experimental imaging are used to compare the IVIM encoding efficiency of spinecho-and stimulated-echo-based DWI/DTI for assessing myocardial perfusion. Methods: Using normalized phase distributions and statistical models of capillary networks derived from histological studies, along with typical diffusion gradient waveforms for in vivo cardiac DWI/DTI, Monte Carlo simulations were performed. The simulation results were compared to IVIM measurements of perfused porcine hearts regarding both magnitude and phase modulation. An IVIM tensor model was used to account for anisotropy of the capillary network, and potential bias of parameter estimation was reported based on simulations. Results: Both computer simulations and experimental data demonstrate a low sensitivity of spin-echo DWI/DTI sequences for IVIM parameters, whereas stimulatedecho-based DWI/DTI with typical mixing times can differentiate between no-flow baseline and perfused myocardium (+129% IVIM-derived flow). In addition, ischemic territories induced by coronary occlusion could be successfully detected. With increasing order of motion compensation (M0/M1/M2) of the diffusion encoding gradients, as required for cardiac in vivo spin-echo DWI/DTI, the low IVIM sensitivity of spin-echo DWI/DTI decreased further in simulations: maximum attenuations of perfusion compartment 52/13/5% (b = 500 s/mm 2 ). Conclusion: Given the short encoding time of spin-echo-based DWI/DTI sequences, a limited perfusion sensitivity results, in particular in combination with motioncompensated diffusion gradients. In contrast, stimulated-echo based DWI/DTI has the potential to identify perfusion changes in cardiac IVIM in vivo. K E Y W O R D S DWI, intravoxel incoherent motion, motion-compensated spin-echo, myocardial perfusion, perfused heart, STEAM F I G U R E 2 Gradient shapes, 0th moments, and integrals of the 0th moment. Normalized effective gradient shapes of Stejskal-Tanner SE-DWI (M0, red), first-order motion-compensated SE-DWI (M1, green), second-order motion-compensated SE-DWI (M2, blue), and STEAM-DWI (orange). The normalized time on the x-axis corresponds to the timing used in the simulations and ex vivo studies. The bottom row shows the integral of the 0th gradient moment (multiplied by the normalized b-value), which is used for generation of phase distributions M0,

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Section: Introductionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI

Spinner

Stoeck

Mathez

et al. 2019

Magnetic Resonance in Med

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“…Arterial spin labelling (ASL) has been applied to the heart in experimental and clinical settings [13]. Also, intra voxel incoherent motion (IVIM) measurements have allowed assessing perfusion fractions without the use of contrast agents [14–16]. However, both approaches provide limited contrast-to-noise ratios (CNR) compared to contrast-enhanced first-pass perfusion imaging and further research is required to translate these methods into clinical use.…”

Section: Introductionmentioning

confidence: 99%

Hyperpolarized 13C urea myocardial first-pass perfusion imaging using velocity-selective excitation

Füetterer

Busch

Peereboom

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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BackgroundA velocity-selective binomial excitation scheme for myocardial first-pass perfusion measurements with hyperpolarized 13C substrates, which preserves bolus magnetization inside the blood pool, is presented. The proposed method is evaluated against gadolinium-enhanced 1H measurements in-vivo.MethodsThe proposed excitation with an echo-planar imaging readout was implemented on a clinical CMR system. Dynamic myocardial stress perfusion images were acquired in six healthy pigs after bolus injection of hyperpolarized 13C urea with the velocity-selective vs. conventional excitation, as well as standard 1H gadolinium-enhanced images. Signal-to-noise, contrast-to-noise (CNR) and homogeneity of semi-quantitative perfusion measures were compared between methods based on first-pass signal-intensity time curves extracted from a mid-ventricular slice. Diagnostic feasibility is demonstrated in a case of septal infarction.ResultsVelocity-selective excitation provides over three-fold reduction in blood pool signal with a two-fold increase in myocardial CNR. Extracted first-pass perfusion curves reveal a significantly reduced variability of semi-quantitative first-pass perfusion measures (12–20%) for velocity-selective excitation compared to conventional excitation (28–93%), comparable to that of reference 1H gadolinium data (9–15%). Overall image quality appears comparable between the velocity-selective hyperpolarized and gadolinium-enhanced imaging.ConclusionThe feasibility of hyperpolarized 13C first-pass perfusion CMR has been demonstrated in swine. Comparison with reference 1H gadolinium data revealed sufficient data quality and indicates the potential of hyperpolarized perfusion imaging for human applications.Electronic supplementary materialThe online version of this article (doi:10.1186/s12968-017-0364-4) contains supplementary material, which is available to authorized users.

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Evaluation of myocardial microcirculation using intravoxel incoherent motion imaging

Mou

Zhang

et al. 2017

Magnetic Resonance Imaging

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In vivo free‐breathing DTI and IVIM of the whole human heart using a real‐time slice‐followed SE‐EPI navigator‐based sequence: A reproducibility study in healthy volunteers

Abstract: The slice-following DWI SE-EPI sequence is a promising solution for clinical implementation, offering a robust improved workflow for further evaluation of DWI in cardiology. Magn Reson Med 76:70-82, 2016. © 2015 Wiley Periodicals, Inc.

Cited by 52 publications

References 51 publications

On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI

On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI

Hyperpolarized 13C urea myocardial first-pass perfusion imaging using velocity-selective excitation

Evaluation of myocardial microcirculation using intravoxel incoherent motion imaging

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