In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

Sesaki, Hiromi; Adachi, Yoshihiro; Kageyama, Yusuke; Itoh, Kie; Iijima, Miho

doi:10.1016/j.bbadis.2013.11.024

Cited by 48 publications

(40 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Membrane constriction is necessary, as the DLP1 ring has a restricted diameter and cannot encircle a whole organelle. For example, tubular mitochondria, which also depend on DLP1 for division, are generally~300 nm in diameter [147] whilst mitochondrial constriction sites have been measured at around 110 nm which correlates with the diameter of the DLP1 ring [104]. Similar observations have been made for peroxisomes [77].…”

Section: Constricting Peroxisomes Prior To Fissionsupporting

confidence: 55%

Proliferation and fission of peroxisomes — An update

Schrader

Costello

Godinho

et al. 2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

124

142

View full text Add to dashboard Cite

In mammals, peroxisomes perform crucial functions in cellular metabolism, signalling and viral defense which are essential to the health and viability of the organism. In order to achieve this functional versatility peroxisomes dynamically respond to molecular cues triggered by changes in the cellular environment. Such changes elicit a corresponding response in peroxisomes, which manifests itself as a change in peroxisome number, altered enzyme levels and adaptations to the peroxisomal structure. In mammals the generation of new peroxisomes is a complex process which has clear analogies to mitochondria, with both sharing the same division machinery and undergoing a similar division process. How the regulation of this division process is integrated into the cell's response to different stimuli, the signalling pathways and factors involved, remains somewhat unclear. Here, we discuss the mechanism of peroxisomal fission, the contributions of the various division factors and examine the potential impact of post-translational modifications, such as phosphorylation, on the proliferation process. We also summarize the signalling process and highlight the most recent data linking signalling pathways with peroxisome proliferation.

show abstract

Section: Constricting Peroxisomes Prior To Fissionsupporting

confidence: 55%

Proliferation and fission of peroxisomes — An update

Schrader

Costello

Godinho

et al. 2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

124

142

View full text Add to dashboard Cite

show abstract

“…Cellular metabolism relies on mitochondria to provide energy from oxidative phosphorylation. Mitochondria are highly dynamic organelles that constantly fuse and divide to maintain normal cellular functions (Figure 1) [3-8]. When this delicate balance between division and fusion is lost, mitochondrial function, metabolism, and signaling are altered.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial division and fusion in metabolism

Roy

Reddy

Iijima

et al. 2015

Current Opinion in Cell Biology

Self Cite

184

164

View full text Add to dashboard Cite

Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle’s function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

show abstract

“…To accommodate these diverse functions, mitochondria adopt different shapes, sizes, numbers and distributions in different cell types [3–7]. The morphological organization of mitochondria is regulated primarily by organelle fusion and division.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy

Zhang

Tamura

Roy

et al. 2014

Cell. Mol. Life Sci.

Self Cite

View full text Add to dashboard Cite

Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.

show abstract

In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

Cited by 48 publications

References 100 publications

Proliferation and fission of peroxisomes — An update

Proliferation and fission of peroxisomes — An update

Mitochondrial division and fusion in metabolism

Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy

Contact Info

Product

Resources

About