In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such as nanozymes, photocatalysts, and electrocatalysts, have been applied in vivo to initiate catalytic reactions and modulate biological microenvironments for generating therapeutic effects. The rapid growth of research in biomedical applications of nanocatalysts has led to the concept of “nanocatalytic medicine,” which is expected to promote the further advance of such a subdiscipline in nanomedicine. The high efficiency and selectivity of catalysis that chemists strived to achieve in the past century can be ingeniously translated into high efficacy and mitigated side effects in theranostics by using “nanocatalytic medicine” to steer catalytic reactions for optimized therapeutic outcomes. Here, the rationale behind the construction of nanocatalytic medicine is eludicated based on the essential reaction factors of catalytic reactions (catalysts, energy input, and reactant). Recent advances in this burgeoning field are then comprehensively presented and the mechanisms by which catalytic nanosystems are conferred with theranostic functions are discussed in detail. It is believed that such an emerging catalytic therapeutic modality will play a more important role in the field of nanomedicine.

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Section: Definition Of “Nanocatalytic Medicine”mentioning

confidence: 99%

Nanocatalytic Medicine

2019

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“…In particular, by combining their unique physicochemical properties (such as fluorescence, X-ray absorption, and paramagnetic properties, etc. ), nanozymes have been widely explored from in vitro detection (Leng et al, 2009;Liang et al, 2010;Roy et al, 2012) to in vivo disease imaging and therapy (Hyon Bin et al, 2010;Yang et al, 2012;Kwon et al, 2016;Singh et al, 2017;Fan et al, 2018). In this review, we summarized the progress of nanozymes in disease detection and imaging, and discussed the current challenges and future directions of nanozyme development in disease imaging and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Nanozymes: A New Disease Imaging Strategy

Wang

Hong

et al. 2020

Front. Bioeng. Biotechnol.

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Nanozymes are nanomaterials with intrinsic enzyme-like properties. They can specifically catalyze substrates of natural enzymes under physiological condition with similar catalytic mechanism and kinetics. Compared to natural enzymes, nanozymes exhibit the unique advantages including high catalytic activity, low cost, high stability, easy mass production, and tunable activity. In addition, as a new type of artificial enzymes, nanozymes not only have the enzyme-like catalytic activity, but also exhibit the unique physicochemical properties of nanomaterials, such as photothermal properties, superparamagnetism, and fluorescence, etc. By combining the unique physicochemical properties and enzyme-like catalytic activities, nanozymes have been widely developed for in vitro detection and in vivo disease monitoring and treatment. Here we mainly summarized the applications of nanozymes for disease imaging and detection to explore their potential application in disease diagnosis and precision medicine.

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“…(A N =14.8 G, A H β =14.8 G, g= 2.0064) was observed when Cu 2− x Te NEs were mixed with H 2 O 2 . The steady‐state kinetic parameters for the POD‐mimicking activity of the Cu 2− x Te NEs were measured with 3,3′,5,5′‐tetramethylbenzidine (TMB) as a substrate (Figure e and Table ) . The values of V max and K M were determined to be 0.73±0.04 μ m s −1 and 189±24 m m , respectively.…”

Section: Resultsmentioning

confidence: 99%

“…For example, gold nanoparticles (NPs) as artificial glucose oxidases have been widely used to convert intratumoral glucose into H 2 O 2 for antitumor therapy . Nitrogen‐doped carbon nanomaterials with oxidase‐ and peroxidase‐like (POD) activities are reported to generate reactive oxygen species (ROS) for tumor regression . In spite of the therapeutic potential of artificial enzymes, their effect on antitumor immunity remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

et al. 2019

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Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems is to build antitumor immunity. However, immunotherapeutic efficacy is highly impeded by the immunosuppressive state of the tumors. Here a new strategy is presented, catalytic immunotherapy based on artificial enzymes. Cu2−xTe nanoparticles exhibit tunable enzyme‐mimicking activity (including glutathione oxidase and peroxidase) under near‐infrared‐II (NIR‐II) light. The cascade reactions catalyzed by the Cu2−xTe artificial enzyme gradually elevates intratumor oxidative stress to induce immunogenic cell death. Meanwhile, the continuously generated oxidative stress by the Cu2−xTe artificial enzyme reverses the immunosuppressive tumor microenvironment, and boosts antitumor immune responses to eradicate both primary and distant metastatic tumors. Moreover, immunological memory effect is successfully acquired after treatment with the Cu2−xTe artificial enzyme to suppress tumor relapse.

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In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Cited by 879 publications

References 40 publications

Nanocatalytic Medicine

Nanocatalytic Medicine

Nanozymes: A New Disease Imaging Strategy

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

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