In vivo hair re-growth efficacies of minoxidil preparations: distearyldimethylammonium chloride vesicles, cellulose acetate phthalate microparticles, and poloxamer solution

The science of formulation involving cosmetic ingredients has always been a challenge since the release of active components greatly depends upon the carrier system involved and the selectivity of skin barrier. The principle obstacle of the skin resides in the epidermis and it's hard for many active components to cross it. The formulation related factors like size of particles, viscosity and lipophilicity of the components also play an important role in permeation of the dermal composition. Though widely used; conventional creams and gels still struggle in terms of success. This work focuses on nano based formulation strategies for successful delivery of cosmetic agents. Novel strategies like nanoemulsion, nanogels, liposomes, aquasomes, niosomes, dendrimers and fullerenes have paved way for successful delivery of dermal formulations to desire depths in the skin.

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Section: Role Of Nanomaterials In Cosmeticsmentioning

confidence: 99%

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Ahmad

Khan

et al. 2018

Drug Res (Stuttg)

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“…Solid lipid nanoparticles, nanoemulsions and nanostructured lipid carriers are the main types of matrix nanoparticles while liposomes are the main type of vesicular particles evaluated in permeation studies. Other types cited in the literature include niosomes [99], cubosomes [100,101], bicellar systems [102], vesicles [103,104] and nanodispersions [105]. As in the previous table, Table 1.2 provides details of the studies which are discussed herein, regarding the skin permeation/penetration studies performed with lipid nanoparticles.…”

Section: Lipid Systemsmentioning

confidence: 99%

“…This occurrence can reduce the skin barrier function and occlude the skin surface [106,107], favoring the skin penetration process. Thus, an increase in the permeation to the receptor medium [99,108,109,110,111,112,113,114] or in the penetration into the skin layers [104,105,115,116,117,118,119] of the active substance is commonly observed when it is encapsulated in different lipid-based nanoparticles, either matrical or vesicular. The lipid components [98,100,120] or the surfactant components of nanoparticles can interact with the skin [109,121].…”

Section: Lipid Systemsmentioning

confidence: 99%

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

Contri

Fiel

Pohlmann

et al. 2011

Nanocosmetics and Nanomedicines

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Abstract. Nanotechnology can be used to modify the drug permeation/penetration of encapsulated substances, through the manipulation of many different factors, including direct contact with the skin surface and controlled release. In general, nanoparticles cannot cross the skin barrier, which can be explained by the cell cohesion and lipids of the stratum corneum, the outermost skin layer. The device most commonly used to study the transport of substances and nanoparticles across the skin is the Franz vertical diffusion cell, followed by the substance quantification in the receptor fluid or determination of the amount retained in the skin. Microscopy techniques have also been applied in skin penetration or permeation experiments. This chapter will present the fundamental considerations regarding the transport of encapsulated substances and/or nanoparticles across the skin, the experimental models applied in these studies and a review of the main studies reported in the literature in order to allow the reader to gain insight into the current knowledge available in this area.

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In vivo hair re-growth efficacies of minoxidil preparations: distearyldimethylammonium chloride vesicles, cellulose acetate phthalate microparticles, and poloxamer solution

Cited by 2 publications

References 10 publications

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

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