In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI

Isoda, Haruo; Ohkura, Yasuhide; Kosugi, Takashi; Hirano, Minoru; Takeda, Hiroyasu; Hiramatsu, Hisaya; Yamashita, Shuhei; Takehara, Yasuo; Alley, Marcus T.; Bammer, Roland; Pelc, Norbert J.; Namba, Hiroki; Sakahara, Harumi

doi:10.1007/s00234-009-0635-3

Cited by 74 publications

(52 citation statements)

References 21 publications

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“…Although OSI was significant throughout the LV, the apex recorded significantly higher 3D and axial OSI than the base and midV (Table 1). High OSI in arteries is frequently associated with vascular pathologies 20, 21…”

Section: Resultsmentioning

confidence: 99%

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

McCormick

Manduchi

Witschey

et al. 2016

JAHA

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BackgroundUnlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences in left ventricular wall shear stress and their association with endocardial endothelial cell gene expression.Methods and ResultsLocal wall shear stress was calculated from 4‐dimensional flow magnetic resonance imaging in 3 distinct regions of human (n=8) and pig (n=5) left ventricle: base, adjacent to the outflow tract; midventricle; and apex. In both species, wall shear stress values were significantly lower in the apex and midventricle relative to the base; oscillatory shear index was elevated in the apex. RNA sequencing of the endocardial endothelial cell transcriptome in pig left ventricle (n=8) at a false discovery rate ≤10% identified 1051 genes differentially expressed between the base and the apex and 327 between the base and the midventricle; no differentially expressed genes were detected at this false discovery rate between the apex and the midventricle. Enrichment analyses identified apical upregulation of genes associated with translation initiation including mammalian target of rapamycin, and eukaryotic initiation factor 2 signaling. Genes of mitochondrial dysfunction and oxidative phosphorylation were also consistently upregulated in the left ventricular apex, as were tissue factor pathway inhibitor (mean 50‐fold) and prostacyclin synthase (5‐fold)—genes prominently associated with antithrombotic protection.ConclusionsWe report the first spatiotemporal measurements of wall shear stress within the left ventricle and linked regional hemodynamics to heterogeneity in ventricular endothelial gene expression, most notably to translation initiation and anticoagulation properties in the left ventricular apex, in which oscillatory shear index is increased and wall shear stress is decreased.

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Section: Resultsmentioning

confidence: 99%

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

McCormick

Manduchi

Witschey

et al. 2016

JAHA

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“…These are well summarized by Singh et al 42 Two hemodynamic indices, wall shear stress (WSS) and oscillatory shear index (OSI), have received particular attention due to their influence on endothelial cell behavior. 6,40 Although studies from Rayz et al, 36 Boussel et al, 1 and Isoda et al 22 showed that in vivo measurement of these quantities is possible using magnetic resonance, inherent limitations in the current technology impede its use, especially for smaller aneurysms, in large cohort studies.…”

Section: Introductionmentioning

confidence: 99%

Computational Hemodynamics in Cerebral Aneurysms: The Effects of Modeled Versus Measured Boundary Conditions

et al. 2010

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Abstract-Modeling of flow in intracranial aneurysms (IAs) requires flow information at the model boundaries. In absence of patient-specific measurements, typical or modeled boundary conditions (BCs) are often used. This study investigates the effects of modeled versus patient-specific BCs on modeled hemodynamics within IAs. Computational fluid dynamics (CFD) models of five IAs were reconstructed from threedimensional rotational angiography (3DRA). BCs were applied using in turn patient-specific phase-contrast-MR (pc-MR) measurements, a 1D-circulation model, and a physiologically coherent method based on local WSS at inlets. The Navier-Stokes equations were solved using the Ansys Ò -CFX TM software. Wall shear stress (WSS), oscillatory shear index (OSI), and other hemodynamic indices were computed. Differences in the values obtained with the three methods were analyzed using boxplot diagrams. Qualitative similarities were observed in the flow fields obtained with the three approaches. The quantitative comparison showed smaller discrepancies between pc-MR and 1D-model data, than those observed between pc-MR and WSS-scaled data. Discrepancies were reduced when indices were normalized to mean hemodynamic aneurysmal data. The strong similarities observed for the three BCs models suggest that vessel and aneurysm geometry have the strongest influence on aneurysmal hemodynamics. In absence of patient-specific BCs, a distributed circulation model may represent the best option when CFD is used for large cohort studies.

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“…Thus the WSS can serve not only as a marker for increased stress and thus a vessel wall location that is particularly at risk but also as a disease course parameter in known vessel pathology [12,13]. A relationship between WSS and the occurrence/rupture of intracranial aneurysms is presumed [14,15].…”

Section: Wall Shear Stress (Wss)mentioning

confidence: 99%

4D-Flow MRI: Technique and Applications

Sträter

Huber

Rudolph

et al. 2018

Fortschr Röntgenstr

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ABSTR AC TBackground Blood flow through the cavities of the heart and great vessels is pulsatile and is subject to time and multidirectional variations. To date, the recording of blood flow in multiple directions and phases has been limited. 4D-flow MRI offers advantages for the recording, visualization and analysis of blood flow.Method The status quo of the method was summarized through analysis with the PubMed database using the keywords "4D-flow MRI, phase-contrast magnetic resonance imaging, MR flow imaging/visualization, MR flow quantification, 3 D cine (time-resolved) phase-contrast CMR, threedirectional velocity-encoding MRI". Methode Basierend auf einer Literaturrecherche in der PubMed-Datenbank mit den Begriffen "4D-Flow-MRI, Phasecontrast magnetic-resonance-imaging, MR-flow-imaging/-visualization, MR-Flow-quantification, 3D-cine (time-resolved) phase-contrast CMR, three-directional velocity-encoding MR" wurde der aktuelle Stand der Methode in dieser Über-sichtsarbeit zusammengefasst.Ergebnisse/Schlussfolgerung Diese Übersichtsarbeit fasst den aktuellen Stand der technischen Entwicklung der 4D-Flussmessung zusammen, diskutiert ihre Vor-und Nachteile und zeigt Anwendungsmöglichkeiten auf. Schließlich werden die wichtigsten Prinzipien und Parameter erklärt, sodass der Leser über die Anwendung der Methode, die möglichen klinischen Indikationen, die Auswertung verschiedener Parameter durch Post-processing-Methoden und die Limitationen des Verfahrens relevante Informationen erhält. Review 1025Sträter A et al. 4D-Flow

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In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI

Abstract: Each intracranial aneurysm in this study had at least one spiral flow. The WSS was lower and OSI was higher at the apex of the spiral flow than the whole aneurysmal wall.

Cited by 74 publications

References 21 publications

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

Computational Hemodynamics in Cerebral Aneurysms: The Effects of Modeled Versus Measured Boundary Conditions

4D-Flow MRI: Technique and Applications

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