In vivo hepatic volume determination using sonography and computed tomography

Thiel, David H. Van; Hagler, N.G.; Schade, Robert R.; Skolnick, M. Leon; Heyl, A.Pollitt; Rosenblum, Elaine; Gavaler, J. S.; Penkrot, R.J.

doi:10.1016/0016-5085(85)90005-8

Cited by 146 publications

(105 citation statements)

References 1 publication

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“…The data presented clearly demonstrate that a small-far-size intact liver transplanted into a larger host increases in size rapidly over [2][3] wk to achieve a size consistent with that of a normal-sized liver in a normal individual of the same size, age, and sex as the recipient. Several mechanisms may be at least partially responsible for this observation.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Rapid growth of an intact human liver transplanted into a recipient larger than the donor

Thiel¹,

Gavaler²,

Kam³

et al. 1987

Gastroenterology

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102

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Section: Discussionmentioning

confidence: 65%

“…attempts at matching the recipient of an orthotopic liver transplant (OL T) with the best available donor in terms of organ and body size are made (1,2). Occasionally, however, only a small donor is available and thus a small·for-size liver is transplanted urgently into a recipient who is considerably larger but is in serious need of I transplant.…”

mentioning

confidence: 99%

Rapid growth of an intact human liver transplanted into a recipient larger than the donor

Thiel¹,

Gavaler²,

Kam³

et al. 1987

Gastroenterology

Self Cite

102

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“…The surgical specimen's weight was used as the reference standard for the RV measurement, assuming that 1 g of parenchyma was equal to 1 cc; despite some authors [72] having reported that CT overestimates hepatic volume in comparison with the immersion of the surgical specimen in water, used for the ex vivo intraoperative volume measurement according to Archimedes' principle. This approximation is acceptable because we considered it as the same for the two analysis methods.…”

Section: Methodsmentioning

confidence: 99%

Liver volumetry: Is imaging reliable? Personal experience and review of the literature

D’Onofrio

Robertis

Demozzi

et al. 2014

WJR

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The amount of the future liver remnant volume is fundamental for hepato-biliary surgery, representing an important potential risk-factor for the development of post-hepatectomy liver failure. Despite this, there is no uniform consensus about the amount of hepatic parenchyma that can be safely resected, nor about the modality that should be chosen for this evaluation. The pre-operative evaluation of hepatic volume, along with a precise identification of vascular and biliar anatomy and variants, are therefore necessary to reduce surgical complications, especially for extensive resections. Some studies have tried to validate imaging methods [ultrasound, computed tomography (CT), magnetic resonance imaging] for the assessment of liver volume, but there is no clear evidence about the most accurate method for this evaluation. Furthermore, this volumetric evaluation seems to have a certain degree of error, tending to overestimate the actual hepatic volume, therefore some conversion factors, which should give a more reliable evaluation of liver volume, have been proposed. It is widespread among non-radiologists the use of independent software for an off-site volumetric analysis, performed on digital imaging and communications in medicine images with their own personal computer, but very few studies have provided a validation of these methods. Moreover, while the pre-transplantation volumetric assessment is fundamental, it remains unclear whether it should be routinely performed in all patients undergoing liver resection. In this editorial the role of imaging in the estimation of liver volume is discussed, providing a review of the most recent literature and a brief personal series of correlations between liver volumes and resection specimens' weight, in order to assess the precision of the volumetric CT evaluation.

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“…The concept that density of liver tissue is equal to that of water was widely accepted in the past decades till recently [5,[14][15][16][17][18]. This concept was reported by Van Thiel et al in 1985, where he demonstrated a close correlation between liver weight and volume of water at 25ºC. Since then, liver volume in milliliters was equated to liver weight in grams on a one to one basis [13].…”

Section: Introductionmentioning

confidence: 99%

“…This concept was reported by Van Thiel et al in 1985, where he demonstrated a close correlation between liver weight and volume of water at 25ºC. Since then, liver volume in milliliters was equated to liver weight in grams on a one to one basis [13]. Despite that, discrepancy between liver volume assessed preoperatively by CT and actual liver weight has been commonly reported making this concept disputable and it became questionable whether 1 milliliter of liver volume actually weighs 1 gram [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

A novel formula for graft weight estimation from preoperative computed tomography volumetric measurement in living donor liver transplantation

Zakareya¹,

Abbasy²,

Abdel-Razek³

et al. 2017

Transplant Technol

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Background: Computed tomography (CT) is the current gold standard for preoperative assessment of graft volume in the context of living donor liver transplantation (LDLT) despite the commonly noted mismatch between CT estimated graft volume (CT-GV) and actual graft weight (AGW). Aim: to find a formula that correlates preoperative virtual CT graft volume with AGW measured on the back table. Methods: CT volumetric data as well as AGW of 125 consecutive living liver donors in the period between 2010 and 2016 were reviewed. Correlation between CT-GV and AGW was done. Formula for line of best fit was obtained by plotting CT-GV against AGW for right and left lobes using linear regression analysis. Results: One hundred and nineteen living donors had complete data allowing downstream analysis. Donors were mostly males (59.7%) with mean age of 28.4±6.7 years. Ninety-seven of them (81.5%) donated right lobe while 22 (18.5%) left lobe grafts. Mean CT-GV was 870.0±142.9 ml for right lobe grafts and 335.5±112.1 ml for left lobe grafts. Mean AGW was 851.7±162.9 g for right lobe grafts and 296.2±74.5 g for left lobe grafts. The following formulae were derived to calculate AGW (g): [0.92xCT-GV (ml)+51.48; R 2 =0.651, P<0.0001] and [0.53xCT-GV (ml)+120; R 2 =0.625, P<0.0001)] for the right and left lobe grafts respectively. Conclusion: We postulate reliable formulae to convert virtual CT-GV into AGW, to accurately correct the discrepancy between preoperative CT-GV and AGW in the setting of LDLT.

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In vivo hepatic volume determination using sonography and computed tomography

Cited by 146 publications

References 1 publication

Rapid growth of an intact human liver transplanted into a recipient larger than the donor

Rapid growth of an intact human liver transplanted into a recipient larger than the donor

Liver volumetry: Is imaging reliable? Personal experience and review of the literature

A novel formula for graft weight estimation from preoperative computed tomography volumetric measurement in living donor liver transplantation

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