In Vivo High-Definition Optical Coherence Tomography

Su, Peiqi; Cao, Taige; Tang, Mark B Y; Tey, Hong Liang

doi:10.1001/jamadermatol.2014.2668

Cited by 20 publications

(15 citation statements)

References 4 publications

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“…After early inflammatory stages, the vasculature is affected [31,32,33,34]. The blood vessels are rarefied, causing necrosis of the fingertips due to ischaemia.…”

Section: Inflammatory Conditionsmentioning

confidence: 99%

Dynamic Optical Coherence Tomography in Dermatology

Ulrich¹,

et al. 2016

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Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows the in vivo evaluation of blood vessels and their distribution within specific lesions, providing additional functional information and consequently greater density of data. In an effort to assess the potential of D-OCT for future scientific and clinical studies, we have therefore reviewed the literature and preliminary unpublished data on the visualization of the microvasculature using D-OCT. Information on D-OCT in skin cancers including melanoma, as well as in a variety of other skin diseases, is presented in an atlas. Possible diagnostic features are suggested, although these require additional validation.

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“…After early inflammatory stages, the vasculature is affected [31,32,33,34]. The blood vessels are rarefied, causing necrosis of the fingertips due to ischaemia.…”

Section: Inflammatory Conditionsmentioning

confidence: 99%

Dynamic Optical Coherence Tomography in Dermatology

Ulrich¹,

et al. 2016

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“…When applied to the skin, the largest organ in the human body, OCT is often used to screen for melanomas or carcinomas, 157 , 158 or to characterize more common dermatology lesions 159 such as rashes, mites/parasites, inflammatory diseases, 160 even acne 161 . Handheld systems in this specialty need to be able to provide as deep imaging as possible to visualize the full-thickness structures of skin, along with other OCT variants that help to differentiate these conditions, such as Doppler or vascular imaging, to measure the local density of vessels 162 .…”

Section: Stage 2 Systems: Biological Discovery Through Technical Innomentioning

confidence: 99%

Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

Monroy¹,

Won

Spillman³

et al. 2017

J. Biomed. Opt

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Since the inception of optical coherence tomography (OCT), advancements in imaging system design and handheld probes have allowed for numerous advancements in disease diagnostics and characterization of the structural and optical properties of tissue. OCT system developers continue to reduce form factor and cost, while improving imaging performance (speed, resolution, etc.) and flexibility for applicability in a broad range of fields, and nearly every clinical specialty. An extensive array of components to construct customized systems has also become available, with a range of commercial entities that produce high-quality products, from single components to full systems, for clinical and research use. Many advancements in the development of these miniaturized and portable systems can be linked back to a specific challenge in academic research, or a clinical need in medicine or surgery. Handheld OCT systems are discussed and explored for various applications. Handheld systems are discussed in terms of their relative level of portability and form factor, with mention of the supporting technologies and surrounding ecosystem that bolstered their development. Additional insight from our efforts to implement systems in several clinical environments is provided. The trend toward well-designed, efficient, and compact handheld systems paves the way for more widespread adoption of OCT into point-of-care or point-of-procedure applications in both clinical and commercial settings.

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“…18 Optical coherence tomography uses a low-intensity, infrared laser beam, and produces high-resolution images of superficial skin structures. 19 The technique has been used in adult morphoea to identify early fibrosis but there is a paucity of any study in the paediatric population.…”

Section: Measurement Of Disease Activity and Biomarkersmentioning

confidence: 99%

Paediatric morphoea: a holistic review. Part 2: diagnosis, measures of disease activity, management and natural history

Kaushik

Mahajan

et al. 2020

Clin Exp Dermatol

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Paediatric morphoea is a debilitating fibrosing disorder of uncertain aetiology, affecting the skin and subcutaneous tissues. Defining optimum management strategies in paediatric morphoea remains an ongoing challenge, owing to the varied presentations and a relative paucity of paediatric-specific studies. We performed a literature search on PubMed, MEDLINE and Google Scholar, using keywords such as 'pediatric morphea', 'juvenile localised scleroderma' and 'juvenile systemic sclerosis'. Relevant studies, including randomized trials, reviews of standard current guidelines and original research articles, were selected and results analysed before summarizing them. In Part 1 of this review, we described the epidemiology, aetiopathogenesis and clinical classification; in this part, we discuss the diagnosis, markers of disease activity, management and natural history in paediatric morphoea. ImagingInfrared thermography can be used to detect activity in lesions of morphoea, with active lesions showing raised temperature. One study reported thermography to have 92% sensitivity and 68% specificity in identifying active

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In Vivo High-Definition Optical Coherence Tomography

Cited by 20 publications

References 4 publications

Dynamic Optical Coherence Tomography in Dermatology

Dynamic Optical Coherence Tomography in Dermatology

Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

Paediatric morphoea: a holistic review. Part 2: diagnosis, measures of disease activity, management and natural history

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