In vivo high-efficiency targeted photodynamic therapy of ultra-small Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes based on small size effect

Abstract

Effectively prolonging the residence time of nanoprobes in the tumor region and reducing the accumulation of nanoprobes in the vital organs (for example, lung, liver and spleen) is crucial for high-efficiency photodynamic therapy (PDT) of cancer. Herein, we systematically report an ultra-small and highly stable nanoplatform with diameters of 4, 8 and 13 nm that exhibited excellent photodynamic therapeutic efficacy using Fe 3 O 4 @polymer-NPO/PEG-Glc@Ce6 nanoprobes. Based on the small size effect, the nanoprobes displayed lower cytotoxicity and excellent biocompatibility. Owing to the synergistic virtues of markedly active targeting and intrinsic small size effect, the Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes can effectively prolong their residence time in the tumor region and reduce accumulation in the normal organs. Benefitting from the small size effect, the synthesized Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes exhibited excellent tumor-targeting capability and photodynamic therapeutic efficacy by inhibiting the growth of tumors in mice under visible red light irradiation with a relatively lower power. The successful application of the small size effect in Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes to significantly improve the PDT efficiency in our strategy suggests new building blocks for PDT of tumors and paves a new way for clinical therapies and translation in the near future.

Applications of Phosphorene and Black Phosphorus in Energy Conversion and Storage Devices

“…The graphene aerogel set afloat on seawater surface by Zhu and co‐workers, Luo and co‐workers, and Wang and co‐workers showed exciting performance in vaporizing the aqueous surface into steam under sunlight irradiation, which is a facile route for the efficient collection of drinkable water. Because phosphorene has better phototherapy potential than graphene, the phosphorene/polymer matrix may find promising application in solar steam production with high efficiency and low cost.…”

Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability

“…It can enhance the high permeability and retention effect of the drug in solid tumor and improve the circulation time in the blood. In addition, multi-functional nano-carriers can endow them with targeting function and improve the selective uptake efficiency of cells (Moros et al, 2013;Wang et al, 2016;Yin et al, 2017;Wang et al, 2018). Human serum albumin (HSA) is a kind of human-derived substance, which has the characteristics of non-toxicity, non-immunogenicity and good biocompatibility (Kratz, 2008).…”

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

“…Nanoparticles are also promising carriers for PSs, as they can be designed to provide excellent biocompatibility, improve the stability, increase the efficiency of delivery to targeted tissues, overcome the blood-brain barrier (BBB) (Dixit et al 2015) or cell-membrane transporters (Roh et al 2017), and to enhance the generation of singlet oxygen by PSs. (Clement et al 2017;Kautzka et al 2017) For instance, Ting Yin et al assembled Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes which have prolonged residence time in tumour tissue and reduced accumulation in the normal organs, due to their targeting ability, ultra-small size and high stability (Yin et al 2017). Polymeric nanoparticles are capable of adsorbing on cell surfaces and accumulate in cells due to cellular uptake mechanisms.…”