In vivo histopathology using endocytoscopy for non-neoplastic changes in the gastric mucosa: a prospective pilot study (with video)

Sato, Hiroki; Inoue, Haruhiro; Hayee, Bu’Hussain; Ikeda, Haruo; Sato, Chiaki; Phalanusitthepha, Chainarong; Santi, Esperanza Grace; Kobayashi, Yasutoshi; Kudo, Shin Ei

doi:10.1016/j.gie.2014.08.019

Cited by 18 publications

(13 citation statements)

References 33 publications

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“…There were mainly 3 colour types including typical red (Colour type 1), red ringed with purple (Colour type 2) and red with yellow in the centre and purple in the periphery (Colour type 3). These types of colour changes may be explained by the pathology of the mucosal lesions 21, 22 , which is evidenced by the close correlation between the CMV diagnosis and the pathological diagnosis. Intestinal metaplasia was observed as purple under LCI, inflammation was observed as red, and the normal mucosa or tumour was observed as yellow.…”

Section: Discussionmentioning

confidence: 90%

Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases

Sun¹,

Bi²,

Dong³

et al. 2017

Sci Rep

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Gastric diseases are common in China, and gastroduodenoscopy could provide accurate diagnoses. Our previous study verified that linked colour imaging (LCI) can improve endoscopic diagnostic accuracy. This study aimed for the first time to establish an LCI-based endoscopic model called colour-microstructure-vessel (CMV) criteria and validated its clinical feasibility for detecting distal gastric diseases manifested as red mucosal lesions under endoscopy in a cohort of 62 patients. Colour features were extracted from the endoscopic images and categorized into 3 types. Colour type 1 was a typical red; Colour type 2 was red ringed with purple and Colour type 3 was red with yellow in the centre and purple around the periphery, allowing for predicting chronic nonatrophic gastritis, chronic atrophic gastritis and gastric cancer. The sensitivity, specificity and Youden index of Colour type 3 with abnormal M or V for gastric cancer were 100.0%, 98.2% and 98.2%. The kappa values for intra-observer and inter-observer agreement for predicting the pathology were 0.834 and 0.791 for experienced endoscopists and 0.788 and 0.732 for endoscopy learners, and these values were comparable regardless of the experience of the endoscopists (P > 0.05). These findings support that the CMV criteria are a promising model for accurate endoscopic diagnosis.

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Section: Discussionmentioning

confidence: 90%

Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases

Sun¹,

Bi²,

Dong³

et al. 2017

Sci Rep

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“…The sensitivity and specificity of the method were 85.4 and 81.7% for gastric inflammation, 71.8 and 95.2% for gastric intestinal metaplasia, and 80 and 98.9% for gastric carcinoma, respectively [39]. In another study, endocytoscopy had 100% PPV for differentiating between normal tissue and intestinal metaplasia; however, the PPV for chronic gastritis and atrophic gastritis was only 62.5 and 40%, respectively [40].…”

Section: Invasive Tests Endoscopymentioning

confidence: 95%

Epidemiology and Diagnosis of Helicobacter pylori infection

2015

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During the period reviewed, prevalence studies were essentially performed in less economically advanced countries and a high prevalence was found. The traditional risk factors for Helicobacter pylori positivity were mostly found. Transmission studied by molecular typing showed a familial transmission. The eventual role of water transmission was explored in several studies with controversial results. Concerning diagnosis, most of the invasive and noninvasive methods used for the diagnosis of H. pylori infection are long standing with efficient performance. The most interesting recent improvements in H. pylori diagnosis include advances in endoscopy, developments in molecular methods, and the introduction of omics-based techniques. Interpretation of old or newer method should take into account the pretest probability and the prevalence of H. pylori in the population under investigation.

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“…However, in this study, 10 of the 82 lesions investigated could not be clearly observed by ECS due to poor staining due to viscous mucus or plaque 49. Sato et al 50 further demonstrated that ECS could differentiate between normal antrum mucosa and preneoplastic changes, whereby they were able to identify four different mucosal patterns in the antrum in a small single-centre pilot study consisting of 64 patients, where the positive predictive values for associating type 1 pattern for normal mucosa and type 4 pattern for gastric intestinal metaplasia were both 100%.…”

Section: Emerging Technologiesmentioning

confidence: 59%

Advanced endoscopic imaging in gastric neoplasia and preneoplasia

Lee

Lim

Yeoh

2017

BMJ Open Gastroenterol

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Conventional white light endoscopy remains the current standard in routine clinical practice for early detection of gastric cancer. However, it may not accurately diagnose preneoplastic gastric lesions. The technological advancements in the field of endoscopic imaging for gastric lesions are fast growing. This article reviews currently available advanced endoscopic imaging modalities, in particular chromoendoscopy, narrow band imaging and confocal laser endomicroscopy, and their corresponding evidence shown to improve diagnosis of preneoplastic gastric lesions. Raman spectrometry and polarimetry are also introduced as promising emerging technologies.

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In vivo histopathology using endocytoscopy for non-neoplastic changes in the gastric mucosa: a prospective pilot study (with video)

Cited by 18 publications

References 33 publications

Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases

Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases

Epidemiology and Diagnosis of Helicobacter pylori infection

Advanced endoscopic imaging in gastric neoplasia and preneoplasia

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