In vivo hypothermic perfusion during renal surgery

Farcon, Eduardo; Morales, Pablo; Al‐Askari, Salah

doi:10.1016/s0090-4295(74)80152-4

Cited by 17 publications

(2 citation statements)

References 17 publications

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“…Otherwise, recommended techniques for renal hypothermia range from surface cooling to hypothermic perfusion. 10,13,15,20,22,23 In the latter instance, renal protection has been observed with single, cold bolus perfusion of the renal artery, intermittent renal artery perfusion, continuous pulsatile perfusion, renal vein perfusion, and cold perfusion of the collecting system. 10 Of these options, our group has used intermittent, cold perfusion of the renal artery combined with surface cooling.…”

Section: Discussionmentioning

confidence: 99%

“…10,[14][15][16][17] Both surface cooling and various methods of perfusion hypothermia have been proposed; however, the advantages of each are not welldefined. 10,13,15,[18][19][20][21][22][23] In light of these uncertainties, this retrospective report describes our institution's experience with complex renal artery repair requiring hypothermic preservation. The intent of the review is to describe (1) the renal artery lesions managed by these techniques, (2) the methods and techniques of renal protection, (3) the hypertension and renal function response to operative management, and (4) the patency of renal artery repair.…”

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confidence: 99%

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Branch renal artery repair with cold perfusion protection

Crutchley

Pearce

Craven

et al. 2007

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Branch renal artery repair with cold perfusion protection

Crutchley

Pearce

Craven

et al. 2007

Journal of Vascular Surgery

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In situ hypothermic renal perfusion Evaluation of three intracellular solutions

Zahran¹,

Farid²,

Ali³

et al. 1980

Urology

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Minimal physiologic temperature variations during renal ischemia alter functional and morphologic outcome

Pelkey

Frank

Stanley

et al. 1992

Journal of Vascular Surgery

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Aortic and renal vascular reconstruction often involve significant renal ischemia. Profound hypothermia during renal ischemia preserves renal tissue. However, in the clinical setting of vascular reconstruction specific attempts at cooling the kidney are often impractical, and renal ischemia frequently occurs at physiologic temperatures. This study demonstrates that minimal temperature changes during renal ischemia alter the functional and morphologic outcome. Rats anesthetized with halothane underwent a right nephrectomy and placement of a snare around the left renal pedicle for 45 minutes to produce renal ischemia. Seventy-five adult male Sprague-Dawley rats, weighing 250 to 350 gm were divided into three groups based on the body temperature maintained during renal ischemia (35 degrees C, 37 degrees C, 39 degrees C). Body temperature was continuously monitored with a rectal thermistor and maintained by adjustment of a heating pad and lamp. Two postischemic protocols were followed including a creatinine assessment protocol with blood samples collected at 24, 48, and 72 hours and a histologic assessment protocol with biopsy of the kidney at 30 hours. At 24 hours after ischemia plasma creatinine concentrations were increased in rats with elevated body temperatures (35 degrees C vs 37 degrees C; [p = 0.001], 37 degrees C vs 39 degrees C; [p = 0.150]). The 30-hour histologic assessment indicated a difference in morphologic outcome (35 degrees C vs 37 degrees C; [p = 0.063], 37 degrees C vs 39 degrees C; [p = 0.016]), with proximal tubular morphology being better maintained at lower temperatures.(ABSTRACT TRUNCATED AT 250 WORDS)

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In vivo hypothermic perfusion during renal surgery

Cited by 17 publications

References 17 publications

Branch renal artery repair with cold perfusion protection

Branch renal artery repair with cold perfusion protection

In situ hypothermic renal perfusion Evaluation of three intracellular solutions

Minimal physiologic temperature variations during renal ischemia alter functional and morphologic outcome

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